New One-pot Cross-coupling Reaction between Grignard Reagents and Alkoxymethyldiphenylphosphonium Iodides in situ-Formed from Alcohols, Chlorodiphenylphosphine and Iodomethane

2003 ◽  
Vol 32 (8) ◽  
pp. 676-677 ◽  
Author(s):  
Taichi Shintou ◽  
Wataru Kikuchi ◽  
Teruaki Mukaiyama
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Grignard Reagents ◽  
One Pot ◽  
Cross Coupling Reaction

A facile and convenient sequential homobimetallic catalytic approach towards β-methylstyrenes. A one-pot Stille cross-coupling/isomerization strategy

2014 ◽  
Vol 12 (22) ◽  
pp. 3735-3743 ◽  
Author(s):  
Sebastián O. Simonetti ◽  
Enrique L. Larghi ◽  
Teodoro S. Kaufman
Keyword(s):  
Double Bond ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Aryl Halides ◽  
One Pot ◽  
Cross Coupling Reaction

A one-pot approach towards β-methylstyrenes is reported. The transformation involves a Stille cross-coupling reaction of aryl halides with allyltributylstannane, followed by an in situ Pd-catalyzed double bond conjugative migration.

scholarly journals Iron-Catalyzed Cross-Coupling of Bis-(aryl)manganese Nucleophiles with Alkenyl Halides: Optimization and Mechanistic Investigations

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 723 ◽  
Author(s):  
Lidie Rousseau ◽  
Alexandre Desaintjean ◽  
Paul Knochel ◽  
Guillaume Lefèvre
Keyword(s):  
Reaction Mechanism ◽  
1H Nmr ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
One Pot ◽  
Aryl Bromides ◽  
Cross Coupling Reaction ◽  
Manganese Species

Various substituted bis-(aryl)manganese species were prepared from aryl bromides by one-pot insertion of magnesium turnings in the presence of LiCl and in situ trans-metalation with MnCl2 in THF at −5 °C within 2 h. These bis-(aryl)manganese reagents undergo smooth iron-catalyzed cross-couplings using 10 mol% Fe(acac)3 with various functionalized alkenyl iodides and bromides in 1 h at 25 °C. The aryl-alkenyl cross-coupling reaction mechanism was thoroughly investigated through paramagnetic 1H-NMR, which identified the key role of tris-coordinated ate-iron(II) species in the catalytic process.

Synthesis of Internal Alkynes through an Effective Tandem ­Elimination–Hydrodebromination–Cross-Coupling of gem-­Dibromoalkenes with Halobenzenes

Synlett ◽  
2017 ◽  
Vol 29 (02) ◽  
pp. 209-214 ◽  
Author(s):  
Yuan Ji ◽  
Ning Zhong ◽  
Zinan Kang ◽  
Guobing Yan ◽  
Ming Zhao
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Sonogashira Coupling ◽  
Reaction Conditions ◽  
One Pot ◽  
Cross Coupling Reaction ◽  
Sonogashira Coupling Reaction ◽  
Palladium Catalyzed ◽  
Internal Alkyne

Carbon–carbon couplings are among the most important strategies for constructing functional molecules in organic synthetic chemistry, and cheap, diverse, and readily available coupling partners are crucial to these diverse reactions. In this contribution, we report the first palladium-catalyzed C–C cross-coupling reaction of two kinds of organic halide, a gem-dibromoalkene and a halobenzene, as the starting materials. Terminal alkynes were generated in situ through a tandem elimination–hydrodebromination process, and the internal alkyne final products were synthesized in one pot. The reaction proceeded under simple, facile, and classic copper-free Sonogashira coupling reaction conditions in good to excellent yields.

Synthesis of Shape-Persistent Macrocycles by a One-Pot Suzuki-Miyaura Cross-Coupling Reaction

2010 ◽  
Vol 17 (2) ◽  
pp. 440-444 ◽  
Author(s):  
Weiguo Huang ◽  
Ming Wang ◽  
Chun Du ◽  
Yulan Chen ◽  
Ruiping Qin ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
One Pot ◽  
Cross Coupling Reaction
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