Double Strand DNA Cleavage by a Dinuclear Cu(II) Complex

2003 ◽  
Vol 32 (6) ◽  
pp. 490-491 ◽  
Author(s):  
Jung Hee Kim ◽  
Soo Hyun Kim
Keyword(s):  
Dna Cleavage ◽  
Double Strand Dna

Zinc and Copper Complexes of Prodigiosin:  Implications for Copper-Mediated Double-Strand DNA Cleavage

2003 ◽  
Vol 5 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Gyungse Park ◽  
John T. Tomlinson ◽  
Matt S. Melvin ◽  
Marcus W. Wright ◽  
Cynthia S. Day ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Copper Complexes ◽  
Double Strand Dna

scholarly journals Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments]

Blood ◽  
1996 ◽  
Vol 87 (7) ◽  
pp. 2649-2658 ◽  
Author(s):  
PD Aplan ◽  
DS Chervinsky ◽  
M Stanulla ◽  
WC Burhans
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Model Systems ◽  
Site Specific ◽  
Breakpoint Cluster Region ◽  
Cluster Region ◽  
Topoisomerase Ii Inhibitors ◽  
Mll Gene ◽  
Secondary Leukemias ◽  
Double Strand Dna

The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute leukemias. Recently, it has become apparent that the MLL gene is very frequently disrupted by chromosomal translocations in patients with secondary leukemias associated with chemotherapeutic regimens incorporating topoisomerase II inhibitors. These secondary leukemias associated with topoisomerase II inhibitors (most commonly teniposide, etoposide, or doxorubicin) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors. We have identified a site within the MLL breakpoint cluster region (bcr) that is highly sensitive to double- strand DNA cleavage induced by topoisomerase II inhibitors. This finding is quite specific and highly reproducible. Although it was initially discovered in malignant lymphoblasts isolated from a patient receiving multiagent chemotherapy, this site-specific double-strand DNA cleavage can be induced in tissue culture using malignant cell lines as well as peripheral blood from normal individuals. Site-specific cleavage occurs in a significant fraction of cells using a variety of model systems, is both time and dose dependent, and can be induced with either doxorubicin or etoposide. This site-specific cleavage maps to the same region as a consensus topoisomerase II cleavage site within the MLL bcr. These results suggest that site specific cleavage within the MLL bcr induced by topoisomerase II inhibitors may be an early step leading to MLL translocations and secondary leukemia.

Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity

2008 ◽  
Vol 102 (5-6) ◽  
pp. 1090-1103 ◽  
Author(s):  
Vivian Chagas da Silveira ◽  
Juliana Silva Luz ◽  
Carla Columbano Oliveira ◽  
Ilaria Graziani ◽  
Maria Rosa Ciriolo ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antitumor Activity ◽  
Dna Cleavage ◽  
Potential Antitumor ◽  
Double Strand Dna

DNA and protein binding, double-strand DNA cleavage and cytotoxicity of mixed ligand copper(II) complexes of the antibacterial drug nalidixic acid

2017 ◽  
Vol 174 ◽  
pp. 1-13 ◽  
Author(s):  
Rangasamy Loganathan ◽  
Mani Ganeshpandian ◽  
Nattamai S.P. Bhuvanesh ◽  
Mallayan Palaniandavar ◽  
Amsaveni Muruganantham ◽  
...  
Keyword(s):  
Protein Binding ◽  
Nalidixic Acid ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Antibacterial Drug ◽  
Double Strand Dna

An IDB-containing low molecular weight short peptide as an efficient DNA cleavage reagent

2015 ◽  
Vol 13 (15) ◽  
pp. 4524-4531 ◽  
Author(s):  
Chunying Ma ◽  
Huan Chen ◽  
Chao Li ◽  
Jin Zhang ◽  
Renzhong Qiao
Keyword(s):  
Molecular Weight ◽  
Aspartic Acid ◽  
Dna Cleavage ◽  
Low Molecular Weight ◽  
Short Peptide ◽  
Artificial Nucleases ◽  
Amine Conjugates ◽  
Double Strand Dna

We present poly(aspartic acid) grafting bis-amine conjugates as artificial nucleases, which can effectively induce double-strand DNA cleavage.

Mechanism of Double-Strand DNA Cleavage Effected by Iron-Bleomycin

1998 ◽  
Vol 53 (9-10) ◽  
pp. 867-870 ◽  
Author(s):  
Teruyuki Kobayashi ◽  
Li Li Guo ◽  
Yuzo Nishida
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Cleavage ◽  
Supercoiled Form ◽  
Cleavage Efficiency ◽  
Important Clue ◽  
Double Strand Dna

We have observed that in the absence of hydrogen peroxide the Fe(III)-bleomycin (BLM) complex exhibits high DNA cleavage efficiency, converting supercoiled Form I DNA (pBR322 or Φxl74) to Form II (nicked, relaxed circular); the present study may give an important clue to elucidate the fact that iron-bleomycin mediated double-strand DNA cleavage requires at least one molecule of oxygen (O2) over the amount required to form “activated bleomycin”.

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