Nucleophilic O-Transfer, Cyclizaton, and Decarboxylation of Carbonyl Oxide Intermediate in the Reaction of Stable Imidazolylidene and Singlet Oxygen

2002 ◽  
Vol 31 (8) ◽  
pp. 796-797 ◽  
Author(s):  
Katsuya Ishiguro ◽  
Kenji Hirabayashi ◽  
Takayuki Nojima ◽  
Yasuhiko Sawaki
Keyword(s):  
Singlet Oxygen ◽  
Carbonyl Oxide

Study of carbonyl oxide formation in the reaction of singlet oxygen with diphenyldiazomethane

1984 ◽  
Vol 106 (24) ◽  
pp. 7623-7624 ◽  
Author(s):  
H. L. Casal ◽  
S. E. Sugamori ◽  
J. C. Scaiano
Keyword(s):  
Singlet Oxygen ◽  
Carbonyl Oxide ◽  
Oxide Formation

ChemInform Abstract: Nucleophilic O-Transfer, Cyclization, and Decarboxylation of Carbonyl Oxide Intermediate in the Reaction of Stable Imidazolylidene and Singlet Oxygen.

ChemInform ◽  
2010 ◽  
Vol 33 (49) ◽  
pp. no-no
Author(s):  
Katsuya Ishiguro ◽  
Kenji Hirabayashi ◽  
Takayuki Nojima ◽  
Yasuhiko Sawaki
Keyword(s):  
Singlet Oxygen ◽  
Carbonyl Oxide

Fluoroquinolone Antimicrobials: Singlet Oxygen, Superoxide and Phototoxicity

1998 ◽  
Vol 67 (4) ◽  
pp. 399 ◽  
Author(s):  
Lydia J. Martínez ◽  
Robert H. Sik ◽  
Colin F. Chignell
Keyword(s):  
Singlet Oxygen

A singlet oxygen sensor for photodynamic cancer therapy

1999 ◽  
Author(s):  
Philip B. Keating ◽  
Michael F. Hinds ◽  
Steven J. Davis
Keyword(s):  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Oxygen Sensor ◽  
Photodynamic Cancer Therapy

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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