New Insulin-Mimetic Zinc (II) Complexes; Bis-maltolato Zinc(II) and Bis-(2-hydroxypyridine-N-oxido) Zinc(II) with Zn(O4) Coordination Mode

2000 ◽  
Vol 29 (8) ◽  
pp. 874-875 ◽  
Author(s):  
Yutaka Yoshikawa ◽  
Eriko Ueda ◽  
Kenji Kawabe ◽  
Hiroyuki Miyake ◽  
Hiromu Sakurai ◽  
...  
Keyword(s):  
Coordination Mode ◽  
Insulin Mimetic

A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) Coordination Mode

1999 ◽  
Vol 28 (9) ◽  
pp. 913-914 ◽  
Author(s):  
Hiromu Sakurai ◽  
Hiromi Sano ◽  
Toshikazu Takino ◽  
Hiroyuki Yasui
Keyword(s):  
Coordination Mode ◽  
Insulin Mimetic ◽  
Vanadyl Complex ◽  
New Type ◽  
Orally Active

Synthesis of Oxovanadium(IV) and Zinc(II) Complexes of 3-Hydroxy-4-(p-substituted)phenylthiazole-2(3H)-thiones with a S2O2 Coordination Mode and Their Insulin-Mimetic Activities

Heterocycles ◽  
2007 ◽  
Vol 73 (1) ◽  
pp. 603 ◽  
Author(s):  
Akira Katoh ◽  
Mika Yamaguchi ◽  
Ryota Saito ◽  
Yusuke Adachi ◽  
Yutaka Yoshikawa ◽  
...  
Keyword(s):  
Coordination Mode ◽  
Insulin Mimetic

Insulin-mimetic effects of short-term Rapamycin in type 1 diabetic patients prior islet transplantation

2017 ◽  
Author(s):  
Federica Ermetici ◽  
Silvia Briganti ◽  
Stefano Benedini ◽  
Roberto Codella ◽  
Paola Maffi ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Diabetic Patients ◽  
Short Term ◽  
Insulin Mimetic ◽  
Type 1 Diabetic Patients

A novel coordination mode for dithiatetrazocines: preparation, x-ray structure, and fluxional behavior of [Pt(PPh3)(1,5-Ph4P2N4S2)]2

1990 ◽  
Vol 29 (17) ◽  
pp. 3068-3069 ◽  
Author(s):  
Tristram Chivers ◽  
Mark Edwards ◽  
Pramesh N. Kapoor ◽  
Auke Meetsma ◽  
Johan C. Van de Grampel ◽  
...  
Keyword(s):  
Coordination Mode ◽  
X Ray

scholarly journals The Role of the Disulfide Bridge in the Copper (II) Binding by the Cyclic His4-Peptide

2021 ◽  
Vol 22 (12) ◽  
pp. 6458
Author(s):  
Aleksandra Pieniężna ◽  
Weronika Witak ◽  
Aneta Szymańska ◽  
Justyna Brasuń
Keyword(s):  
Metal Ions ◽  
Coordination Mode ◽  
Transition Metal Ions ◽  
Disulfide Bridge ◽  
Chain Flexibility ◽  
Vis Spectroscopy ◽  
Ph Range ◽  
Cd Studies ◽  
Metal Ratios

In this paper, we present studies on the influence of the disulfide bridge on the copper (II) ions’ binding abilities by the cyclic His4-peptide. The studied ligand HKHPHRHC-S-S-C consists of nine amino acids. The cyclic structure was obtained through a disulfide bridge between two cysteinyl groups. Moreover, this peptide is characterized by the presence of four His residues in the sequence, which makes it an interesting ligand for transition metal ions. The potentiometric and spectroscopic (UV-Vis spectroscopy and circular dichroism spectroscopy (CD)) studies were carried out in various molar ligand to metal ratios: 2:1, 1:1, and 1:2, in the pH range of 2.5–11 at 25 °C. The results showed that the cyclic His4-peptide promotes dinuclear complexes in each of these systems and forms the final dinuclear species with the {NIm, 3N-amide}{NIm, 3N-amide} coordination mode. The obtained data shows that cyclization by the formation of the disulfide bond has an impact on the peptide chain flexibility and appearance of additional potential donors for metal ions and influences the copper (II) ions’ coordination.

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