Element Effect Revisited. Variable and Inverse Element Effect in the SNAr Reaction of Picryl Halide and 2,4-Dimethoxyaniline

1999 ◽  
Vol 28 (7) ◽  
pp. 691-692 ◽  
Author(s):  
Naoki Sugiyama ◽  
Jun-ichi Hayami
Keyword(s):  
Snar Reaction ◽  
Inverse Element

scholarly journals Unexpected results of a SNAr-reaction. A novel synthetic approach to 1-arylthio-2-naphthols

2013 ◽  
Vol 54 (48) ◽  
pp. 6615-6618 ◽  
Author(s):  
Cornelia M. Grombein ◽  
Qingzhong Hu ◽  
Ralf Heim ◽  
Volker Huch ◽  
Rolf W. Hartmann
Keyword(s):  
Synthetic Approach ◽  
Snar Reaction

Studies on the Regioselective Nucleophilic Aromatic Substitution (SNAr) Reaction of 2-Substituted 3,5-Dichloropyrazines

2013 ◽  
Vol 15 (9) ◽  
pp. 2156-2159 ◽  
Author(s):  
Stephanie Scales ◽  
Sarah Johnson ◽  
Qiyue Hu ◽  
Quyen-Quyen Do ◽  
Paul Richardson ◽  
...  
Keyword(s):  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Snar Reaction

Straightforward Synthesis of Oligopyrroles through a Regioselective SNAr Reaction of Pyrroles and Halogenated Boron Dipyrrins

2014 ◽  
Vol 16 (7) ◽  
pp. 1952-1955 ◽  
Author(s):  
Ting Jiang ◽  
Ping Zhang ◽  
Changjiang Yu ◽  
Jian Yin ◽  
Lijuan Jiao ◽  
...  
Keyword(s):  
Snar Reaction

(±)-1,2-Dialkyl-5-nitro-2,3-dihydro-1H-indoles by a tandem reductive amination-SNAr reaction

2009 ◽  
Vol 46 (4) ◽  
pp. 629-634 ◽  
Author(s):  
Richard A. Bunce ◽  
Takahiro Nago ◽  
Brian White
Keyword(s):  
Reductive Amination ◽  
Snar Reaction

ChemInform Abstract: Sulfonylation of Five-Membered Heterocycles via an SNAr Reaction.

ChemInform ◽  
2014 ◽  
Vol 45 (21) ◽  
pp. no-no
Author(s):  
Shuai Liang ◽  
Ruo-Yi Zhang ◽  
Long-Yi Xi ◽  
Shan-Yong Chen ◽  
Xiao-Qi Yu
Keyword(s):  
Snar Reaction

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1493-1498 ◽  
Author(s):  
Shinichiro Fuse ◽  
Hiroyuki Nakamura ◽  
Megumi Inaba ◽  
Shinichi Sato ◽  
Manjusha Joshi
Keyword(s):  
Drug Discovery ◽  
Rapid Development ◽  
Ring System ◽  
Biologically Active ◽  
Drug Candidate ◽  
One Pot ◽  
Ring Systems ◽  
Drug Candidates ◽  
Fused Ring ◽  
Snar Reaction

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot SNAr reaction/intramolecular C–H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

scholarly journals On the importance of the novel RIRC technique to highlight the Hidden Intermediate of Reaction in the SNAr Reaction of piperidine on 2-bromo-3,5-dinitrothiophene

Authorea ◽  
2020 ◽  
Author(s):  
Amal SMAOUI ◽  
Khaled ESSALAH ◽  
Xavier Assfeld ◽  
Guillaume Herlem ◽  
Fabien Picaud ◽  
...  
Keyword(s):  
The Novel ◽  
Snar Reaction

Novel Exploration of the SNAr Reaction

Synlett ◽  
1998 ◽  
Vol 1998 (7) ◽  
pp. 794-796 ◽  
Author(s):  
Stéphane Raeppel ◽  
Franck Raeppel ◽  
Jean Suffert
Keyword(s):  
Snar Reaction
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