Synthesis of the High-valent Mn Porphyrin Species by Peroxy Acid Oxidation of MnIIIDimers. Characterization of the MnIV2Species and Evidence of the MnV-MnIIIIntermediate

1998 ◽  
Vol 27 (2) ◽  
pp. 185-186 ◽  
Author(s):  
Kanako Ichihara ◽  
Yoshinori Naruta
Keyword(s):  
Acid Oxidation ◽  
Peroxy Acid ◽  
High Valent

ChemInform Abstract: PEROXY ACID OXIDATION OF ALKYL PHENYL DISULFIDES

1978 ◽  
Vol 9 (46) ◽  
Author(s):  
A. K. BHATTACHARYA ◽  
A. G. HORTMANN
Keyword(s):  
Acid Oxidation ◽  
Peroxy Acid

Peroxy acid oxidation of alkyl phenyl disulfides

1978 ◽  
Vol 43 (13) ◽  
pp. 2728-2730 ◽  
Author(s):  
Ajit K. Bhattacharya ◽  
Alfred G. Hortmann
Keyword(s):  
Acid Oxidation ◽  
Peroxy Acid

Synthesis and Characterization of a Stable High-Valent Cobalt Carbene Complex

2016 ◽  
Vol 138 (17) ◽  
pp. 5531-5534 ◽  
Author(s):  
James A. Bellow ◽  
Sebastian A. Stoian ◽  
Johan van Tol ◽  
Andrew Ozarowski ◽  
Richard L. Lord ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Carbene Complex ◽  
High Valent

scholarly journals Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform

2019 ◽  
Vol 476 (10) ◽  
pp. 1521-1537 ◽  
Author(s):  
Emma J. Goldberg ◽  
Katherine A. Buddo ◽  
Kelsey L. McLaughlin ◽  
Regina F. Fernandez ◽  
Andrea S. Pereyra ◽  
...  
Keyword(s):  
Acid Oxidation ◽  
Valuable Insight ◽  
Keto Acid ◽  
Isolated Mitochondria ◽  
Mouse Tissues ◽  
Branched Chain

Abstract Alterations to branched-chain keto acid (BCKA) oxidation have been implicated in a wide variety of human diseases, ranging from diabetes to cancer. Although global shifts in BCKA metabolism—evident by gene transcription, metabolite profiling, and in vivo flux analyses have been documented across various pathological conditions, the underlying biochemical mechanism(s) within the mitochondrion remain largely unknown. In vitro experiments using isolated mitochondria represent a powerful biochemical tool for elucidating the role of the mitochondrion in driving disease. Such analyses have routinely been utilized across disciplines to shed valuable insight into mitochondrial-linked pathologies. That said, few studies have attempted to model in vitro BCKA oxidation in isolated organelles. The impetus for the present study stemmed from the knowledge that complete oxidation of each of the three BCKAs involves a reaction dependent upon bicarbonate and ATP, both of which are not typically included in respiration experiments. Based on this, it was hypothesized that the inclusion of exogenous bicarbonate and stimulation of respiration using physiological shifts in ATP-free energy, rather than excess ADP, would allow for maximal BCKA-supported respiratory flux in isolated mitochondria. This hypothesis was confirmed in mitochondria from several mouse tissues, including heart, liver and skeletal muscle. What follows is a thorough characterization and validation of a novel biochemical tool for investigating BCKA metabolism in isolated mitochondria.

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