Use of Sodium Nitrite Auxiliary Electrode for Solid Electrolyte Sensor to Detect Nitrogen Oxides

1992 ◽  
Vol 21 (4) ◽  
pp. 587-590 ◽  
Author(s):  
Sheng Yao ◽  
Youichi Shimizu ◽  
Norio Miura ◽  
Noboru Yamazoe
Keyword(s):  
Nitrogen Oxides ◽  
Solid Electrolyte ◽  
Sodium Nitrite ◽  
Auxiliary Electrode

Absorption of nitrogen oxides in alkaline solutions: selective manufacture of sodium nitrite

1990 ◽  
Vol 29 (7) ◽  
pp. 1492-1502 ◽  
Author(s):  
Naresh J. Suchak ◽  
Kanhaiya Jethani ◽  
Jyeshthraj B. Joshi
Keyword(s):  
Nitrogen Oxides ◽  
Sodium Nitrite ◽  
Alkaline Solutions

Influence of Oxygen on Detection of Nitrogen Oxides with Solid Electrolyte Sensor Using NaNO3

1993 ◽  
Vol 22 (2) ◽  
pp. 193-196 ◽  
Author(s):  
Sheng Yao ◽  
Youichi Shimizu ◽  
Norio Miura ◽  
Noboru Yamazoe
Keyword(s):  
Nitrogen Oxides ◽  
Solid Electrolyte

A H2S sensor based on Na-β-alumina as solid electrolyte and Na2S as auxiliary electrode

1997 ◽  
Vol 43 (1-3) ◽  
pp. 230-234 ◽  
Author(s):  
F. Vandecruys ◽  
R. Stephen ◽  
F. De Schutter ◽  
J. Vangrunderbeek
Keyword(s):  
Solid Electrolyte ◽  
Auxiliary Electrode

scholarly journals Pilot Randomized Double-Blind Trial of Treatment of Mycobacterium ulcerans Disease (Buruli Ulcer) with Topical Nitrogen Oxides

2004 ◽  
Vol 48 (8) ◽  
pp. 2866-2870 ◽  
Author(s):  
R. Phillips ◽  
O. Adjei ◽  
S. Lucas ◽  
N. Benjamin ◽  
M. Wansbrough-Jones
Keyword(s):  
Citric Acid ◽  
Nitrogen Oxides ◽  
Sodium Nitrite ◽  
Active Treatment ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans ◽  
Citric Acid Monohydrate ◽  
Ulcer Size ◽  
Group I ◽  
Group Ii

ABSTRACT Mycobacterium ulcerans disease (Buruli ulcer) is a serious ulcerating skin disease which is common in many tropical countries. Standard treatment, by extensive excision and skin grafting, is not available in rural communities where the disease is common. We evaluated the efficacy and safety of treatment with topical nitrogen oxides. Thirty-seven patients with a clinical diagnosis of Buruli ulcer caused by M. ulcerans disease were randomly assigned to one of two groups. In one group, two creams containing sodium nitrite (6%, wt/wt) or citric acid monohydrate (9%, wt/wt) were applied daily for 6 weeks, while the other group received a placebo. In the second 6 weeks, both groups received the nitrogen oxide-generating combination of creams. Treatment was continued for another 4 weeks for patients whose ulcers were not healed after 12 weeks. The ulcer surface area was monitored by weekly tracings made by assessors blinded to the treatment. In the first 6 weeks, patients on sodium nitrite and citric acid monohydrate (group I, active treatment) showed a rapid decrease in ulcer size from 28.6 ± 5.6 cm2 (mean ± standard error) to 12.6 ± 3.2 cm2, a decrease significantly greater than that in group II (from 15.3 ± 3.1 to 11.7 ± 3.7 cm2; P = 0.03). Five ulcers in the placebo group enlarged during this period, compared with one in the active group. In the second 6 weeks (both groups on active treatment), the rates of healing were similar for the two groups and there was a significant reduction in ulcer size in group II (previously on placebo) compared to the first 6 weeks. Yellow pigmentation of the skin, which disappeared 3 days after treatment was stopped, was the only side effect to date. We conclude that creams releasing nitrogen oxides increase the healing rate of ulcers caused by M. ulcerans infection with minimal adverse events. This is the first controlled trial of any form of therapy which demonstrates efficacy in treating this disease.

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