A Novel Rearrangement of 1-Alkynylcyclopropanol to 2-Cyclopenten-1-one via Dicobalt Hexacarbonyl Complex

1992 ◽  
Vol 21 (3) ◽  
pp. 473-476 ◽  
Author(s):  
Nobuharu Iwasawa
Keyword(s):  
Dicobalt Hexacarbonyl

ChemInform Abstract: DICOBALT-HEXACARBONYL COMPLEXES OF ACETYLENIC PHOSPHAZENES

1984 ◽  
Vol 15 (25) ◽  
Author(s):  
H. R. ALLCOCK ◽  
R. A. NISSAN ◽  
P. J. HARRIS ◽  
R. R. WHITTLE
Keyword(s):  
Dicobalt Hexacarbonyl

scholarly journals Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl 2′-Deoxy-5-oxopropynyluridines

ChemistryOpen ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 237-247 ◽  
Author(s):  
Renata Kaczmarek ◽  
Dariusz Korczyński ◽  
Karolina Królewska-Golińska ◽  
Kraig A. Wheeler ◽  
Ferman A. Chavez ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Dicobalt Hexacarbonyl ◽  
Synthesis And Biological Evaluation

Intramolecular Oxonium-Ene-Type Reaction of a Bis(Alkyne-Dicobalt Hexacarbonyl) Complex

Synlett ◽  
2001 ◽  
Vol 2001 (04) ◽  
pp. 0509-0512 ◽  
Author(s):  
Gyles Darren Smyth ◽  
Hirofumi Ohmura ◽  
Koichi Mikami
Keyword(s):  
Type Reaction ◽  
Dicobalt Hexacarbonyl

Synthesis and Crystal Structures of Dicobalt Hexacarbonyl Complexes of Dicationic Alkyne-Bridged Imidazolium and Triazolium Derivates

Heterocycles ◽  
2017 ◽  
Vol 95 (2) ◽  
pp. 1148
Author(s):  
Sven Nerdinger ◽  
Gerhard Laus ◽  
Simone Haslinger ◽  
Stefan Oberparleiter ◽  
Klaus Wurst ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Dicobalt Hexacarbonyl

Efficient Synthesis of O-tert-Propargylic Oximes via Nicholas Reaction

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3461-3465
Author(s):  
Itaru Nakamura ◽  
Keigo Shiga ◽  
Mao Suzuki ◽  
Masahiro Terada
Keyword(s):  
Ammonium Nitrate ◽  
Efficient Synthesis ◽  
Propargylic Alcohols ◽  
Cyclic Nitrones ◽  
Acidic Catalysts ◽  
Nicholas Reaction ◽  
High Yields ◽  
Dicobalt Hexacarbonyl ◽  
Cerium Iv Ammonium Nitrate

A synthetic protocol to access O-tert-propargylic oximes derived from tertiary propargylic alcohols was established via Nicholas reaction. Thus, BF3·OEt2-mediated reaction between the dicobalt hexacarbonyl complex of tert-propargylic alcohols and p-nitrobenzaldoxime followed by decomplexation with cerium(IV) ammonium nitrate afforded the corresponding O-tert-propargylic oximes in good to high yields. The obtained O-tert-propargylic oximes were effectively converted into heterocycles, such as four-membered cyclic nitrones, oxazepines, and isoxazolines, by using π-Lewis acidic catalysts.

ChemInform Abstract: Cyclization of Dicobalt Hexacarbonyl Complexes of 3-Methylhept-6-en-1-yn-3-ol and Its Derivatives on the Surface of Chromatographic Adsorbents.

ChemInform ◽  
1989 ◽  
Vol 20 (31) ◽  
Author(s):  
V. A. SMIT ◽  
S. O. SIMONYAN ◽  
V. A. TARASOV ◽  
A. S. SHASHKOV ◽  
S. S. MAMYAN ◽  
...  
Keyword(s):  
Dicobalt Hexacarbonyl

scholarly journals Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl Alkynyl Modified 2′-Deoxyuridines

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 62
Author(s):  
Roman Dembinski ◽  
Renata Kaczmarek ◽  
Dariusz Korczyński ◽  
Karolina Królewska-Golińska
Keyword(s):  
Cell Line ◽  
K562 Cells ◽  
Biological Evaluation ◽  
Oxygen Species ◽  
K562 Cell Line ◽  
Dicobalt Octacarbonyl ◽  
Cobalt Compounds ◽  
Dicobalt Hexacarbonyl ◽  
Synthesis And Biological Evaluation ◽  
Related Compounds

In continuation of synthetic pursuit of metallo-nucleosides, in particular dicobalt hexacarbonyl 5-alkynyl-2′-deoxyuridines, novel compounds with alkynyl groups were synthesized, starting from 5-iodo-2′-deoxyuridine. Reactions of dicobalt octacarbonyl [Co2(CO)8] with 2′-deoxy-5-oxopropynyluridines and related compounds gave dicobalt hexacarbonyl nucleoside complexes (83–31%). The growth inhibition of HeLa and K562 cancer cell lines by organometallic nucleosides was examined and compared to that by alkynyl nucleoside precursors. Coordination of the dicobalt carbonyl moiety to the 2′-deoxy-5-alkynyluridines led to a significant increase in its cytotoxic potency. The cobalt compounds antiproliferative activities against the HeLa cell line and the K562 cell line will be described. Coordination of an acetyl-substituted cobalt nucleoside was expanded using the 1,1-bis(diphenylphosphino)methane (dppm) ligand, resulting in cytotoxicity at comparable levels. The formation of reactive oxygen species in the presence of cobalt compounds was determined in K562 cells. The results indicate that the mechanism of action for most antiproliferative cobalt compounds may be related to the induction of oxidative stress.

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