Reductive Addition of Alkyl Radical to Phenyl Vinyl Sulfone

1992 ◽  
Vol 21 (11) ◽  
pp. 2169-2172 ◽  
Author(s):  
Hideo Togo ◽  
Masahiko Aoki ◽  
Masataka Yokoyama
Keyword(s):  
Alkyl Radical ◽  
Vinyl Sulfone ◽  
Phenyl Vinyl

ChemInform Abstract: Reductive Addition of Alkyl Radical to Phenyl Vinyl Sulfone.

ChemInform ◽  
2010 ◽  
Vol 24 (22) ◽  
pp. no-no
Author(s):  
H. TOGO ◽  
M. AOKI ◽  
M. YOKOYAMA
Keyword(s):  
Alkyl Radical ◽  
Vinyl Sulfone ◽  
Phenyl Vinyl

scholarly journals A novel LC-MS method development and validation for the determination of phenyl vinyl sulfone in eletriptan hydrobromide

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Indhu Priya Mabbu ◽  
G. Sumathi ◽  
N. Devanna
Keyword(s):  
Method Development ◽  
Limit Of Detection ◽  
Vinyl Sulfone ◽  
Limit Of Quantification ◽  
Relative Standard ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical ◽  
Development And Validation ◽  
Phenyl Vinyl

Abstract Background The aim of the present method is to develop and validate a specific, sensitive, precise, and accurate liquid chromatography-mass spectrometry (LC-MS) method for the estimation of the phenyl vinyl sulfone in the eletriptan hydrobromide. The effective separation of the phenyl vinyl sulfone was achieved by the Symmetry C18 (50 × 4.6 mm, 3.5 μm) column and a mobile phase composition of 0.1%v/v ammonia buffer to methanol (5:95 v/v), using 0.45 ml/min flow rate and 20 μl of injection volume, with methanol used as diluent. The phenyl vinyl sulfone was monitored on atomic pressure chemical ionization mode mass spectrometer with positive polarity mode. Results The retention time of phenyl vinyl sulfone was found at 2.13 min. The limit of detection (LOD) and limit of quantification (LOQ) were observed at 1.43 ppm and 4.77 ppm concentration respectively; the linear range was found in the concentration ranges from 4.77 to 27.00 ppm with regression coefficient of 0.9990 and accuracy in the range of 97.50–102.10%. The percentage relative standard deviation (% RSD) for six replicates said to be injections were less than 10%. Conclusion The proposed method was validated successfully as per ICH guidelines. Hence, this is employed for the determination of phenyl vinyl sulfone in the eletriptan hydrobromide.

scholarly journals Crystal structure of (2R*,3aR*)-2-phenylsulfonyl-2,3,3a,4,5,6-hexahydropyrrolo[1,2-b]isoxazole

2017 ◽  
Vol 73 (1) ◽  
pp. 85-87
Author(s):  
Yaiza Hernández ◽  
Isidro Marcos ◽  
Narciso M. Garrido ◽  
Francisca Sanz ◽  
David Diez
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonds ◽  
Title Compound ◽  
Dipolar Cycloaddition ◽  
Vinyl Sulfone ◽  
Compound C ◽  
Phenyl Vinyl

The title compound, C12H15NO3S, was prepared by 1,3-dipolar cycloaddition of 3,4-dihydro-2H-pyrrole 1-oxide and phenyl vinyl sulfone. In the molecule, both fused five-membered rings display a twisted conformation. In the crystal, C—H...O hydrogen bonds link neighbouring molecules, forming chains running parallel to thebaxis.

scholarly journals Efficiency and Selectivity Aspects in the C–H Functionalization of Aliphatic Oxygen Heterocycles by Photocatalytic Hydrogen Atom Transfer

Synlett ◽  
2019 ◽  
Vol 30 (07) ◽  
pp. 803-808 ◽  
Author(s):  
Carlotta Raviola ◽  
Davide Ravelli
Keyword(s):  
Hydrogen Atom ◽  
Uv Light ◽  
Hydrogen Atom Transfer ◽  
Atom Transfer ◽  
Vinyl Sulfone ◽  
Cyclic Carbonates ◽  
Aromatic Ketones ◽  
Oxygen Heterocycles ◽  
Selectivity Studies ◽  
Phenyl Vinyl

The C–H to C–C conversion in aliphatic oxygen heterocycles (dioxolanes, 1,3-dioxane, or cyclic carbonates) by photocatalytic hydrogen atom transfer and subsequent trapping of the resulting radical with phenyl vinyl sulfone was investigated. The performance of three different photocatalysts, namely tetrabutylammonium decatungstate and the aromatic ketones thioxanthone and 9-fluorenone, was compared. The UV-light-absorbing decatungstate anion is more efficient and permits the use of a smaller excess of hydrogen donor than the aromatic ketones, although the ketones could be excited by visible light. Further intramolecular selectivity studies revealed that aromatic ketones afforded a higher proportion of functionalization at the acetalic versus the ethereal positions than did the decatungstate anion.

ChemInform Abstract: Synthesis of Polyhydroxylated Derivatives of Phenyl Vinyl Sulfone as Structural Analogues of Chalcones.

ChemInform ◽  
2010 ◽  
Vol 32 (43) ◽  
pp. no-no
Author(s):  
Marek T. Konieczny ◽  
Barbara Horowska ◽  
Antoni Kunikowski ◽  
Jerzy Konopa ◽  
Konstanty Wierzba ◽  
...  
Keyword(s):  
Vinyl Sulfone ◽  
Structural Analogues ◽  
Derivatives Of ◽  
Phenyl Vinyl

Asymmetric Michael addition of chiral enaminoesters to phenyl vinyl sulfone and 1,1-bis(phenylsulfonyl)ethylene

1992 ◽  
Vol 3 (8) ◽  
pp. 1003-1006 ◽  
Author(s):  
Sergio Pinheiro ◽  
André Guinganta ◽  
Didier Desmaële ◽  
Jean d'Angelo
Keyword(s):  
Michael Addition ◽  
Vinyl Sulfone ◽  
Asymmetric Michael Addition ◽  
Phenyl Vinyl

ChemInform Abstract: Heck Reactions of Arenediazonium Salts with Phenyl Vinyl Sulfone: A New Synthesis of Styryl Sulfones.

ChemInform ◽  
2010 ◽  
Vol 33 (6) ◽  
pp. no-no
Author(s):  
Saumitra Sengupta ◽  
Subir Kumar Sadhukhan ◽  
Rajkumar Sunil Singh
Keyword(s):  
Vinyl Sulfone ◽  
Heck Reactions ◽  
New Synthesis ◽  
Arenediazonium Salts ◽  
Phenyl Vinyl
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