scholarly journals Synthesis of Allyl Ester of Prostaglandin E and the Conversion of the Allyl Ester Moiety into Carboxylic Acid by Chemical Method. A Highly Practical Synthesis of Natural PGE1and Limaprost

1992 ◽  
Vol 21 (10) ◽  
pp. 2095-2098 ◽  
Author(s):  
Naoya Ono ◽  
Mie Tsuboi ◽  
Sentaro Okamoto ◽  
Tohru Tanami ◽  
Fumie Sato
Keyword(s):  
Carboxylic Acid ◽  
Chemical Method ◽  
Prostaglandin E ◽  
Allyl Ester ◽  
Ester Moiety ◽  
Practical Synthesis

A Practical Synthesis of 1-Oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid Esters

2010 ◽  
Vol 20 (10) ◽  
pp. 1070-1072 ◽  
Author(s):  
Lei Tang ◽  
Yu-She Yang ◽  
Ru-Yun Ji
Keyword(s):  
Carboxylic Acid ◽  
Practical Synthesis ◽  
Acid Esters

A Practical Synthesis of 3,3-Difluorocyclobutane Carboxylic Acid.

ChemInform ◽  
2005 ◽  
Vol 36 (48) ◽  
Author(s):  
Dirk Elend ◽  
David Fengas ◽  
M. Jonathan Fray
Keyword(s):  
Carboxylic Acid ◽  
Practical Synthesis

ChemInform Abstract: Practical Synthesis of 4′-Methylbiphenyl-2-carboxylic Acid.

ChemInform ◽  
2010 ◽  
Vol 26 (34) ◽  
pp. no-no
Author(s):  
T. HATTORI ◽  
N. HAYASHIZAKA ◽  
S. MIYANO
Keyword(s):  
Carboxylic Acid ◽  
Practical Synthesis

A Practical Synthesis of Indole-2-carboxylic Acid

2017 ◽  
Vol 49 (5) ◽  
pp. 476-478
Author(s):  
Ting Jiang ◽  
Ning Liu ◽  
Yi-Wen Jiang ◽  
Ping-Ping Ye ◽  
Wei-Ming Xu
Keyword(s):  
Carboxylic Acid ◽  
Practical Synthesis

scholarly journals Six-Step Gram Scale Synthesis of the HIV Integrase Inhibitor Dolutegravir Sodium

2021 ◽  
Author(s):  
Jule-Phillip Dietz ◽  
Tobias Lucas ◽  
Jonathan Groß ◽  
Sebastian Seitel ◽  
Jan Brauer ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Integrase Inhibitor ◽  
Active Pharmaceutical Ingredient ◽  
Ring System ◽  
Hiv Integrase ◽  
Salt Formation ◽  
One Pot ◽  
Amide Formation ◽  
Practical Synthesis

A short and practical synthesis for preparing the active pharmaceutical ingredient dolutegravir sodium was investigated. The convergent strategy developed herein starts from 3-(R)-amino-1- butanol and builds up the BC ring system in 76% isolated yield over four steps. Ring A was constructed by a one-pot 1,4-addition to diethyl-(2E/Z)-2-(ethoxymethylidene)-3-oxobutandioate and subsequent MgBr2·OEt2-mediated regioselective cyclization. Amide formation with 2,4- difluorobenzylamine was either performed from the carboxylic acid or through aminolysis of the corresponding ester precursor. Final salt formation afforded dolutegravir sodium in 48–51% isolated yield (HPLC-purity: 99.7–99.9%) over six linear steps.<br>

Practical Synthesis of 1H-Indazole-3-carboxylic Acid and Its Derivatives

Heterocycles ◽  
1996 ◽  
Vol 43 (12) ◽  
pp. 2701 ◽  
Author(s):  
Toyokichi Yoshida ◽  
Noriyasu Matsuura ◽  
Katsuhisa Yamamoto ◽  
Masahiro Doi ◽  
Kanji Shimada ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Practical Synthesis
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