scholarly journals Enantioselective Synthesis of Optically Pure Amino Alcohol Derivatives by Yeast Reduction

1987 ◽  
Vol 16 (1) ◽  
pp. 129-132 ◽  
Author(s):  
Tamotsu Fujisawa ◽  
Hiroki Hayashi ◽  
Yoshino Kishioka
Keyword(s):  
Amino Alcohol ◽  
Enantioselective Synthesis ◽  
Optically Pure

Enantioselective synthesis of α,α-difluoro-β-lactams using amino alcohol ligands

2014 ◽  
Vol 12 (33) ◽  
pp. 6484-6489 ◽  
Author(s):  
Atsushi Tarui ◽  
Takeshi Ikebata ◽  
Kazuyuki Sato ◽  
Masaaki Omote ◽  
Akira Ando
Keyword(s):  
Amino Alcohol ◽  
Enantioselective Synthesis ◽  
Reformatsky Reaction

A practical and highly enantioselective Reformatsky reaction of ethyl bromodifluoroacetate with imines using a cheap and commercially available amino alcohol ligand is described.

Highly Enantioselective Synthesis of 1,2-Amino Alcohol Derivatives via Proline-Catalyzed Mannich Reaction.

ChemInform ◽  
2004 ◽  
Vol 35 (6) ◽  
Author(s):  
Peter Pojarliev ◽  
William T. Biller ◽  
Harry J. Martin ◽  
Benjamin List
Keyword(s):  
Mannich Reaction ◽  
Amino Alcohol ◽  
Enantioselective Synthesis

scholarly journals Biomimetic enantioselective synthesis of β,β-difluoro-α-amino acid derivatives

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Qiupeng Peng ◽  
Bingjia Yan ◽  
Fangyi Li ◽  
Ming Lang ◽  
Bei Zhang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Structural Diversity ◽  
Enantioselective Synthesis ◽  
Amino Acid Derivatives ◽  
Proton Shift ◽  
Wide Range ◽  
Fluorine Compounds ◽  
Optically Pure ◽  
High Stereoselectivity ◽  
High Application

AbstractAlthough utilization of fluorine compounds has a long history, synthesis of chiral fluorinated amino acid derivatives with structural diversity and high stereoselectivity is still very appealing and challenging. Here, we report a biomimetic study of enantioselective [1,3]-proton shift of β,β-difluoro-α-imine amides catalyzed by chiral quinine derivatives. A wide range of corresponding β,β-difluoro-α-amino amides were achieved in good yields with high enantioselectivities. The optically pure β,β-difluoro-α-amino acid derivatives were further obtained, which have high application values in the synthesis of fluoro peptides, fluoro amino alcohols and other valuable fluorine-containing molecules.

Sign in / Sign up

Export Citation Format

Share Document