CHEMO- AND REGIOSELECTIVE REDUCTION OF α,β-EPOXY KETONES TO β-HYDROXY KETONES BY SODIUM HYDROGENTELLURIDE

1984 ◽  
Vol 13 (2) ◽  
pp. 271-272 ◽  
Author(s):  
Atsuhiro Osuka ◽  
Koji Taka-Oka ◽  
Hitomi Suzuki
Keyword(s):  
Hydroxy Ketones ◽  
Epoxy Ketones

Hydrazine Hydrate Induced Reductive Cleavage of α,β-Epoxy Ketones: An Efficient Procedure for the Preparation of β-Hydroxy Ketones.

ChemInform ◽  
2005 ◽  
Vol 36 (22) ◽  
Author(s):  
Jorge A. R. Salvador ◽  
Alcino J. L. Leitao ◽  
M. Luisa Sa e Melo ◽  
James R. Hanson
Keyword(s):  
Hydrazine Hydrate ◽  
Reductive Cleavage ◽  
Efficient Procedure ◽  
Hydroxy Ketones ◽  
Epoxy Ketones

scholarly journals Catalytic Hydrogenation of α,β-Epoxy Ketones to Form β-Hydroxy Ketones Mediated by an NADH Coenzyme Model.

ChemInform ◽  
2006 ◽  
Vol 37 (49) ◽  
Author(s):  
Hua-Jian Xu ◽  
You-Cheng Liu ◽  
Yao Fu ◽  
Yun-Dong Wu
Keyword(s):  
Catalytic Hydrogenation ◽  
Hydroxy Ketones ◽  
Epoxy Ketones

scholarly journals Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shengtong Niu ◽  
Hao Zhang ◽  
Weici Xu ◽  
Prasanta Ray Bagdi ◽  
Guoxiang Zhang ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Kinetic Resolution ◽  
Optimal Solution ◽  
Chiral Molecules ◽  
Chiral Catalysts ◽  
Tertiary Alcohols ◽  
Hydroxy Ketones ◽  
Epoxy Ketones ◽  
Current Stage

AbstractContemporary asymmetric catalysis faces huge challenges when prochiral substrates bear electronically and sterically unbiased substituents and when substrates show low reactivities. One of the inherent limitations of chiral catalysts and ligands is their incapability in recognizing prochiral substrates bearing similar groups. This has rendered many enantiopure substances bearing several similar substituents inaccessible. Here we report the rationale, scope, and applications of the strategy of kinetic resolution of auxiliary adjacent alcohols (KRA*) that can be used to solve the above troubles. Using this method, a large variety of optically enriched tertiary alcohols, epoxides, esters, ketones, hydroxy ketones, epoxy ketones, β-ketoesters, and tetrasubstituted methane analogs with two, three, and four spatially and electronically similar groups can be readily obtained (totally 96 examples). At the current stage, the strategy serves as the optimal solution that can complement the inability caused by direct asymmetric catalysis in getting chiral molecules with challenging fully substituted stereocenters.

Hydrazine hydrate induced reductive cleavage of α,β-epoxy ketones: an efficient procedure for the preparation of β-hydroxy ketones

2005 ◽  
Vol 46 (7) ◽  
pp. 1067-1070 ◽  
Author(s):  
Jorge A.R. Salvador ◽  
Alcino J.L. Leitão ◽  
M. Luísa Sá e Melo ◽  
James R. Hanson
Keyword(s):  
Hydrazine Hydrate ◽  
Reductive Cleavage ◽  
Efficient Procedure ◽  
Hydroxy Ketones ◽  
Epoxy Ketones

Metal-Free, One-Pot, Sequential Protocol for Transforming α,β-Epoxy Ketones to β-Hydroxy Ketones and α-Methylene Ketones

2015 ◽  
Vol 80 (3) ◽  
pp. 1593-1600 ◽  
Author(s):  
Eietsu Hasegawa ◽  
Saki Arai ◽  
Eiji Tayama ◽  
Hajime Iwamoto
Keyword(s):  
One Pot ◽  
Metal Free ◽  
Hydroxy Ketones ◽  
Epoxy Ketones
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