scholarly journals COPPER-CATALYZED REACTION OF GRIGNARD REAGENTS WITH β-PROPIOLACTONES: A CONVENIENT METHOD FOR THE SYNTHESIS OF β-SUBSTITUTED PROPIONIC ACIDS

1980 ◽  
Vol 9 (5) ◽  
pp. 571-574 ◽  
Author(s):  
Toshio Sato ◽  
Tatsuo Kawara ◽  
Masatoshi Kawashima ◽  
Tamotsu Fujisawa
Keyword(s):  
Convenient Method ◽  
Grignard Reagents

Copper-catalysed cross-coupling of alkyl Grignard reagents and propargylic ammonium salts: stereospecific synthesis of allenes

2018 ◽  
Vol 54 (60) ◽  
pp. 8343-8346 ◽  
Author(s):  
Manuel Guisán-Ceinos ◽  
Victor Martín-Heras ◽  
Rita Soler-Yanes ◽  
Diego J. Cárdenas ◽  
Mariola Tortosa
Keyword(s):  
Convenient Method ◽  
Cross Coupling ◽  
Ammonium Salts ◽  
Stereospecific Synthesis ◽  
Grignard Reagents ◽  
Chirality Transfer ◽  
High Yields

A robust and convenient method to prepare enantiomerically enriched allenes using propargylic salts is reported. High yields and excellent chirality transfer are observed.

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