scholarly journals SELECTIVE ASYMMETRIC REDUCTION OF α,β-UNSATURATED KETONES VIA HYDROSILYLATION CATALYZED BY RHODIUM(I) COMPLEXES WITH CHIRAL PHOSPHINE LIGANDS

1975 ◽  
Vol 4 (9) ◽  
pp. 985-988 ◽  
Author(s):  
Iwao Ojima ◽  
Tetsuo Kogure ◽  
Yoichiro Nagai
Keyword(s):  
Asymmetric Reduction ◽  
Phosphine Ligands ◽  
Unsaturated Ketones ◽  
Chiral Phosphine Ligands

Rhodium-Catalyzed, Phosphorus(III)-Directed Hydroarylation of Internal Alkynes: Facile and Efficient Access to New Phosphine Ligands

Synlett ◽  
2020 ◽  
Author(s):  
Minyan Wang ◽  
Zhuangzhi Shi ◽  
Huanhuan Luo ◽  
Dawei Wang
Keyword(s):  
High Selectivity ◽  
Enantiomeric Excess ◽  
Phosphine Ligands ◽  
Rapid Construction ◽  
Efficient Access ◽  
Internal Alkynes ◽  
Great Progress ◽  
Chiral Phosphine Ligands ◽  
Optimized Conditions ◽  
Made In

AbstractOrganophosphines are an important class of ligands widely used in organic chemistry. Although great progress has recently been made in the rapid construction of new phosphines through Rh- or Ru-catalyzed C–H bond functionalizations, synthetic access to more diverse phosphines remains a challenge. We describe an efficient process for the rhodium-catalyzed phosphorus(III)-directed hydroarylation of internal alkynes to generate various alkenylated and 2′,6′-dialkenylated biarylphosphines with high selectivity. A range of diverse alkynes and phosphines were effectively prepared with broad functional-group compatibility under the optimized conditions. In addition, the developed protocol can be extended to modify chiral phosphine ligands, providing enantioenriched alkenylated phosphines without erosion of the enantiomeric excess.

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