scholarly journals A Thirst for Enantioselectivity in Catalytic Addition of Alkylnitriles

2019 ◽  
Vol 48 (11) ◽  
pp. 1322-1327
Author(s):  
Naoya Kumagai ◽  
Masakatsu Shibasaki
Keyword(s):  
Catalytic Addition

scholarly journals Synthesis of new derivatives of copper complexes of Josiphos family ligands for applications in asymmetric catalysis

2014 ◽  
Vol 4 (7) ◽  
pp. 1997-2005 ◽  
Author(s):  
R. Oost ◽  
J. Rong ◽  
A. J. Minnaard ◽  
S. R. Harutyunyan
Keyword(s):  
Asymmetric Catalysis ◽  
Copper Complexes ◽  
Grignard Reagents ◽  
Aromatic Ketones ◽  
Asymmetric Catalytic ◽  
Catalytic Addition ◽  
Derivatives Of

New derivatives of copper complexes of Josiphos family ligands have been prepared and studied in asymmetric catalytic addition of Grignard reagents to enones, enoates and aromatic ketones.

scholarly journals Synthesis and Prognosis of Anti-inflammatory Activity of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3h)-one

2021 ◽  
Vol 7 (12) ◽  
pp. 25-33
Author(s):  
A. Chiriapkin ◽  
I. Kodonidi ◽  
A. Ivchenko ◽  
L. Smirnova
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Dimethyl Sulfoxide ◽  
In Silico ◽  
Glacial Acetic Acid ◽  
Inflammatory Activity ◽  
Modified Method ◽  
Anti Inflammatory ◽  
Catalytic Addition ◽  
Derivatives Of

The article presents a modified method for the synthesis of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one and the predict of their anti-inflammatory activity. The proposed method for obtaining tetrahydrothienopyrimidine derivatives is preparatively effective and simple. Their synthesis was carried out by heterocyclization of azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide in the medium of glacial acetic acid with the catalytic addition of dimethyl sulfoxide. Preliminary prognosis of anti-inflammatory activity in silico method allowed us to identify the most promising compounds. Of these, the 4b structure containing a 2-hydroxyphenyl fragment in the second position of pyrimidine-4(3H)-one may be of the greatest interest. It seems appropriate to further study the spectrum of biological activity of the studied compounds.

Chemo- and enantioselective catalytic addition of propargyl chloride to aldehydes promoted by [Cr(Salen)] complexes

2001 ◽  
Vol 12 (7) ◽  
pp. 1063-1069 ◽  
Author(s):  
Marco Bandini ◽  
Pier G. Cozzi ◽  
Paolo Melchiorre ◽  
Roberta Tino ◽  
Achille Umani-Ronchi
Keyword(s):  
Salen Complexes ◽  
Catalytic Addition

scholarly journals Synthesis of L-2-(N-Pteroylamino )-3-(N -phosphonoacetyl)aminopropanoic Acid as an Analogue of the Putative Phosphorylated Intermediate in the γ-Glutamation of Folic Acid by Folylpolyglutamate Synthetase

Pteridines ◽  
1999 ◽  
Vol 10 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Ronald Forsch ◽  
Henry Bader ◽  
Andre Rosowsky
Keyword(s):  
Folic Acid ◽  
Glutamic Acid ◽  
Aspartic Acid ◽  
Catalytic Hydrogenation ◽  
Spatial Orientation ◽  
Sequential Treatment ◽  
Folylpolyglutamate Synthetase ◽  
Phosphonate Esters ◽  
Catalytic Addition

L-2-(N-Pteroyl)amino-3-(N-phosphonoacetyl)aminopropanoic acid was synthesized as an analogue of the putative y-phosphorylated intermediate in the enzyme-catalyzed γ-glutamation of folic acid by folylpolyglutamate synthetase (FPGS). N-(Benzyloxycarbonyl)-L-aspartic acid was converted in four steps to methyl L-2-(N-benzyloxycarbonyl)amino-3-aminopropanoate, and the latter was allowed to react with p-nitrophenyl dimethoxyphosphonoacetate to obtain methyl L-2-(N-benzyloxycarbonylamino)- 3-(N-dimethoxyphosphonoacetyl)aminopropanoate. After catalytic hydrogenation, the resulting amine was coupled to N10-formylpteroic acid via the mixed carboxylic-carbonic anhydride method, and the three ester groups were removed by sequential treatment with Me3SiBr in DMF and NaOH in DMSO. When the last step was performed only with NaOH/DMSO, one of the phosphonate esters remained intact, giving L-2-(N -pteroyl )amino-3 -(N -monOInethoxyphosphonoacetyl )aminopropanoic acid. Also synthesized as a potential FPGS inhibitor was Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nε-phosphonoacetyl- L-Iysine. The ability of these phosphonoacetyl derivatives to inhibit catalytic addition of L-glutamic acid to folic acid proved to be very low, suggesting that replacement of the CH2C(=O)OP(=O)(OH)2 moiety by NHC(=O)CH2P(=O)(OH)2 may place the terminal phosphonyl group in an unfavorable spatial orientation for binding to the enzyme.

Perfluoroalkylation of Coordinated Ethene in Rh(I) and Ir(I) Complexes. Catalytic Addition of Iodoperfluoroalkanes to Ethene

2017 ◽  
Vol 36 (7) ◽  
pp. 1245-1258 ◽  
Author(s):  
María Blaya ◽  
Delia Bautista ◽  
Juan Gil-Rubio ◽  
José Vicente
Keyword(s):  
Catalytic Addition

Benzimidazolin-2-iminato Hafnium Complexes: Synthesis, Characterization, and Catalytic Addition of Alcohols to Carbodiimides

2020 ◽  
Vol 39 (16) ◽  
pp. 3021-3033 ◽  
Author(s):  
Maxim Khononov ◽  
Heng Liu ◽  
Natalia Fridman ◽  
Matthias Tamm ◽  
Moris S. Eisen
Keyword(s):  
Catalytic Addition

Sulfonylimidates as Nucleophiles in Catalytic Addition Reactions

2008 ◽  
Vol 130 (6) ◽  
pp. 1804-1805 ◽  
Author(s):  
Ryosuke Matsubara ◽  
Florian Berthiol ◽  
Shū Kobayashi
Keyword(s):  
Addition Reactions ◽  
Catalytic Addition
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