Design and Synthesis of Optically Pure Dibenzo-difuso-azacentrotriquinacene-based Pseudo-C2-Symmetric Cyclic Hydroxamic Acid

2019 ◽  
Vol 48 (11) ◽  
pp. 1328-1331
Author(s):  
Naoya Ohtsuka ◽  
Masato Seki ◽  
Yujiro Hoshino ◽  
Kiyoshi Honda
Keyword(s):  
Hydroxamic Acid ◽  
Design And Synthesis ◽  
Optically Pure ◽  
Cyclic Hydroxamic Acid

Analogs of the cyclic hydroxamic acid 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3-one (DIMBOA): decomposition to benzoxazolinones and reaction with .beta.-mercaptoethanol

1991 ◽  
Vol 56 (5) ◽  
pp. 1788-1800 ◽  
Author(s):  
Jeffrey Atkinson ◽  
Peter Morand ◽  
John T. Arnason ◽  
Hermann M. Niemeyer ◽  
Hector R. Bravo
Keyword(s):  
Hydroxamic Acid ◽  
Cyclic Hydroxamic Acid

scholarly journals Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA

2011 ◽  
Vol 8 (3) ◽  
pp. 1394-1400
Author(s):  
Lynda Ekou ◽  
Tchirioua Ekou ◽  
Javier Garcia ◽  
Isabelle Opalinski ◽  
Jean Pierre Gesson
Keyword(s):  
Small Molecules ◽  
Histone Deacetylase ◽  
Histone Deacetylases ◽  
Hydroxamic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Suberoylanilide Hydroxamic Acid ◽  
Considerable Potential ◽  
Design And Synthesis

Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors.

Reaction of a cyclic hydroxamic acid from gramineae with thiols

1982 ◽  
Vol 21 (9) ◽  
pp. 2287-2289 ◽  
Author(s):  
Hermann M. Niemeyer ◽  
Luis J. Corcuera ◽  
Francisco J. Pérez
Keyword(s):  
Hydroxamic Acid ◽  
Cyclic Hydroxamic Acid
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