scholarly journals Mechanically Enhanced Hyaluronic Acid Hybrid Hydrogels with Halloysite Nanotubes

2017 ◽  
Vol 46 (8) ◽  
pp. 1217-1219 ◽  
Author(s):  
Kyung-Lynne Park ◽  
Wei Ma ◽  
Yuji Higaki ◽  
Atsushi Takahara
Keyword(s):  
Hyaluronic Acid ◽  
Halloysite Nanotubes ◽  
Hybrid Hydrogels

Arginine derivatives assist dopamine-hyaluronic acid hybrid hydrogels to have enhanced antioxidant activity for wound healing

2020 ◽  
Vol 392 ◽  
pp. 123775 ◽  
Author(s):  
Shaohan Zhang ◽  
Jingyi Hou ◽  
Qijuan Yuan ◽  
Peikun Xin ◽  
Huitong Cheng ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Wound Healing ◽  
Hyaluronic Acid ◽  
Hybrid Hydrogels

Silver Sulphadiazine- xanthan gum- hyaluronic Acid Composite Hydrogel for Wound Healing: Formulation Development and in vivo Evaluation

2020 ◽  
Vol 16 (1) ◽  
pp. 21-29 ◽  
Author(s):  
M.O. Ilomuanya ◽  
Z.A. Seriki ◽  
U.N. Ubani-Ukoma ◽  
B.A. Oseni ◽  
B.O. Silva
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Xanthan Gum ◽  
Wound Closure ◽  
Antimicrobial Agents ◽  
Biological Properties ◽  
Formulation Development ◽  
Hybrid Hydrogels ◽  
Silver Sulphadiazine

Background: Development and modifications of hybrid hydrogels have been done to improve biological properties or to decrease the disadvantages of biomaterials.Objectives: The efficacy of hyaluronic acid in combination with silver sulphadiazine in wound healing was investigated. The retaining properties of xanthan gum to aid re- epithelialization was also explored.Materials and Method: Four hybrid hydrogels comprising of different concentrations of xanthan gum, eugenol and antimicrobial agents – hyaluronic acid and silver sulphadiazine were formulated. The physicochemical properties of the gels were assessed, and the antimicrobial effectiveness of the different hydrogel were determined using the extent of wound closure as an index.Results: The hydrogel samples had approximately 90% moisture content with rate of evaporation between 26- 32% for a 5 h period at 37oC. The pH of all formulations was between 7.59 - 8.05 considering that the formulation would be applied to underlying tissues of the skin. The swelling index after a 12 h period in distilled water was 10% for HX 1, 27% for HX 2, 29% for HX 3 and 30% for HX 4. There was no new peak observed in the FTIR analysis to indicate formation of new bonds.Conclusion: Incorporation of silver sulphadiazine at 0.1% and hyaluronic acid at 1.5% in the formulation yielded the best results with regards to least presence of inflammatory cell infiltrates and excellent wound closure at 14 days compared to the control and other formulations. Further investigation may be required for clinical use as an effective wound dressing material. Keywords: Silver sulphadiazine, Xanthan gum, Hyaluronic acid, Hydrogels, Wound healing.

Double printing of hyaluronic acid/poly(glycidol) hybrid hydrogels with poly( ε -caprolactone) for MSC chondrogenesis

2017 ◽  
Vol 9 (4) ◽  
pp. 044108 ◽  
Author(s):  
Simone Stichler ◽  
Thomas Böck ◽  
Naomi Paxton ◽  
Sarah Bertlein ◽  
Riccardo Levato ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Hybrid Hydrogels

Enzymatically Crosslinkable Hyaluronic Acid-Gelatin Hybrid Hydrogels as Potential Bioinks for Tissue Regeneration

2020 ◽  
Vol 28 (4) ◽  
pp. 400-406 ◽  
Author(s):  
Phuong Le Thi ◽  
Joo Young Son ◽  
Yunki Lee ◽  
Seung Bae Ryu ◽  
Kyung Min Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Tissue Regeneration ◽  
Hybrid Hydrogels

Intra-articular Administrated Hydrogels of Hyaluronic Acid Hybridized with Triptolide/Gold Nanoparticles for Targeted Delivery to Rheumatoid Arthritis Combined with Photothermal-chemo Therapy

2021 ◽  
Author(s):  
Chenxi Li ◽  
Rui Liu ◽  
Yurong Song ◽  
Dongjie Zhu ◽  
Liuchunyang Yu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Invasion And Migration ◽  
Nir Light ◽  
Hybrid Hydrogels ◽  
And Migration

Abstract Triptolide (TP) as a disease-modifying anti-rheumatic drug (DMARD) is effective on the treatment of rheumatoid arthritis (RA). To alleviate the toxicity and elevate therapeutic specificity, hyaluronic acid (HA) hydrogels load RGD-attached gold nanoshell containing TP are synthesized, which can be used for targeted photothermal-chemo therapy, and imaging of RA in vivo. The hydrogels system composed of thiol and tyramine modified HA conjugates has been applied artificial tissue models of cartilage for studying drug delivery and release properties. After the degradation of HA chains, heat together with drugs can be delivered to the inflammatory joints simultaneously due to the near-infrared resonance (NIR) irradiation of Au nanoshell. RA is a chronic inflamed disease, which is characterized by synovial inflammation of multiple joints, and can be penetrated with NIR light. These intra-articular administrated hybrid hydrogels combined with NIR irradiation can improve clinical arthritic conditions and inflamed joints in collagen-induced arthritis (CIA) mice, which just need a smaller dosage of TP with non-toxicity. Additionally, the TP-Au/HA hybrid hydrogels treatment reduced the invasion and migration of RA fibroblast-like synoviocytes (RA-FLSs) in vitro significantly, through reducing the phosphorylation of mTOR and p70S6K, its substrates, and confirmed that the mTOR pathway was inhibited.

Formation of hyaluronic acid–ellagic acid microfiber hybrid hydrogels and their applications

2012 ◽  
Vol 291 (3) ◽  
pp. 515-525 ◽  
Author(s):  
Stacey N. Barnaby ◽  
Nako Nakatsuka ◽  
Stephen H. Frayne ◽  
Karl R. Fath ◽  
Ipsita A. Banerjee
Keyword(s):  
Hyaluronic Acid ◽  
Ellagic Acid ◽  
Hybrid Hydrogels
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