Preparation and Imaging Study of Tumor-targeting MRI Contrast Agent Based on Fe3O4 Nanoparticles

2015 ◽  
Vol 44 (12) ◽  
pp. 1771-1773 ◽  
Author(s):  
Wan’er Chen ◽  
Yuxin Han ◽  
Yu’e Qian ◽  
Jianbin Tang ◽  
Hongjie Hu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Fe3o4 Nanoparticles ◽  
Tumor Targeting ◽  
Imaging Study ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Agent Based

A tumor-targeting MRI contrast agent based on hypoxia and pH-responsive nanogel

2015 ◽  
Vol 213 ◽  
pp. e104-e105
Author(s):  
Tianyu Wang ◽  
Qi Zeng ◽  
Jianbin Tang ◽  
Meihua Sui ◽  
Xiangrui Liu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Targeting ◽  
Mri Contrast Agent ◽  
Ph Responsive ◽  
Mri Contrast ◽  
Agent Based

scholarly journals Preparation and Properties of Tumor-Targeting MRI Contrast Agent Based on Linear Polylysine Derivatives

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1477 ◽  
Author(s):  
Xuanrong Sun ◽  
Yue Cai ◽  
Zhuomin Xu ◽  
Dabu Zhu
Keyword(s):  
Contrast Agent ◽  
Tumor Targeting ◽  
Phenylboronic Acid ◽  
Mri Contrast Agent ◽  
Cell Uptake ◽  
Amino Groups ◽  
Mri Contrast ◽  
Agent Based ◽  
Magnetic Resonance Imaging Mri

We developed a tumor-targeted contrast agent based on linear polylysine (PLL) by conjugating a small molecular imaging agent, fluorescent molecule and targeting agent amino phenylboronic acid onto the amino groups of polylysine, which can specifically target monosaccharide sialic acid residues overexpressing on the surface of tumor cell membranes. Further, 3,4,5,6-Tetrahydrophthalic anhydride (DCA) was attached to the free amino groups of the polylysine to change to a negative charge at physiology pH to lower the cytotoxicity, but it soon regenerated to a positive charge again once reaching the acidic intratumoral environment and therefore increased cell uptake. Laser confocal microscopy images showed that most of the polymeric contrast agents were bound to the cancer cell membrane. Moreover, the tumor targeting contrast agent showed the same magnetic resonance imaging (MRI) contrasting performance in vitro as the small molecule contrast agent used in clinic, which made it a promising tumor-targeting polymeric contrast agent for cancer diagnosis.

Preparation and In Vitro Evaluation of a MRI Contrast Agent Based on Aptamer-Modified Gadolinium-Loaded Liposomes for Tumor Targeting

2016 ◽  
Vol 18 (5) ◽  
pp. 1564-1571 ◽  
Author(s):  
Lan-Xin Zhang ◽  
Kun-Feng Li ◽  
Huan Wang ◽  
Meng-Jie Gu ◽  
Li-Si Liu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Targeting ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
In Vitro Evaluation ◽  
Agent Based

Magnetic Fe3O4 nanoparticles coated by natural rubber latex as MRI contrast agent

2019 ◽  
Vol 475 ◽  
pp. 458-464 ◽  
Author(s):  
Soudabeh Arsalani ◽  
Eder J. Guidelli ◽  
Matheus A. Silveira ◽  
Carlos E.G. Salmon ◽  
Jefferson F.D.F. Araujo ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Natural Rubber ◽  
Fe3o4 Nanoparticles ◽  
Natural Rubber Latex ◽  
Mri Contrast Agent ◽  
Rubber Latex ◽  
Mri Contrast ◽  
Magnetic Fe3o4 Nanoparticles ◽  
Magnetic Fe3o4

An MRI contrast agent based on a zwitterionic metal-chelating polymer for hepatorenal angiography and tumor imaging

2020 ◽  
Vol 8 (31) ◽  
pp. 6956-6963
Author(s):  
Peisen Zhang ◽  
Zihua Wang ◽  
Yiyang Wang ◽  
Yuqing Wang ◽  
Chunyan Liu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Imaging ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Agent Based ◽  
Metal Chelating ◽  
Chelating Polymer

A zwitterionic MRI contrast agent Gd-PAA with exceptionally high r1 was designed for hepatorenal angiography and tumor imaging.

Preparation and characterization of PVPI-coated Fe3O4 nanoparticles as an MRI contrast agent

2013 ◽  
Vol 340 ◽  
pp. 57-60 ◽  
Author(s):  
Guangshuo Wang ◽  
Ying Chang ◽  
Ling Wang ◽  
Zhiyong Wei ◽  
Jianyun Kang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Fe3o4 Nanoparticles ◽  
Mri Contrast Agent ◽  
Mri Contrast

scholarly journals Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (105) ◽  
pp. 86779-86783 ◽  
Author(s):  
M. Borges ◽  
S. Yu ◽  
A. Laromaine ◽  
A. Roig ◽  
S. Suárez-García ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Coordination Polymer ◽  
Contrast Agent ◽  
Polymer Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Agent Based ◽  
Iron Coordination ◽  
T2 Mri

A novel dual T1/T21H-MRI contrast agent based on the encapsulation of super-paramagnetic iron oxide nanoparticles (SPIONs) with an iron coordination polymer is proposed.

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