scholarly journals Insights into Protein Allostery in the CsoR/RcnR Family of Transcriptional Repressors

2014 ◽  
Vol 43 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Khadine A. Higgins ◽  
David Giedroc
Keyword(s):  
Transcriptional Repressors ◽  
Protein Allostery

Phosphotyrosine-Dependent Signaling: the Role of CoREST/REST Transcriptional Repressors in Neuroblastoma

2017 ◽  
Author(s):  
TL Vu-Han ◽  
S Buhs ◽  
H Gerull ◽  
M Horstmann ◽  
P Nollau
Keyword(s):  
Transcriptional Repressors

scholarly journals Publisher Correction: A network of transcriptional repressors modulates auxin responses

Nature ◽  
2020 ◽  
Author(s):  
Jekaterina Truskina ◽  
Jingyi Han ◽  
Elina Chrysanthou ◽  
Carlos S. Galvan-Ampudia ◽  
Stéphanie Lainé ◽  
...  
Keyword(s):  
Transcriptional Repressors

scholarly journals FarRRegulates the farAB-Encoded Efflux Pump of Neisseriagonorrhoeae via an MtrR RegulatoryMechanism

2003 ◽  
Vol 185 (24) ◽  
pp. 7145-7152 ◽  
Author(s):  
E.-H. Lee ◽  
C. Rouquette-Loughlin ◽  
J. P. Folster ◽  
W. M. Shafer
Keyword(s):  
Regulatory Mechanism ◽  
Efflux Pump ◽  
Regulatory Protein ◽  
Transcriptional Repressors ◽  
Sequence Database ◽  
Mobility Shift ◽  
Pump System ◽  
Regulatory Cascade ◽  
Genome Sequence Database ◽  
Gel Mobility Shift

ABSTRACT The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. It was previously observed that expression of the farAB operon was positively regulated by MtrR, which is a repressor of the mtrCDE-encoded efflux pump system (E.-H. Lee and W. M. Shafer, Mol. Microbiol. 33:839-845, 1999). This regulation was believed to be indirect since MtrR did not bind to the farAB promoter. In this study, computer analysis of the gonococcal genome sequence database, lacZ reporter fusions, and gel mobility shift assays were used to elucidate the regulatory mechanism by which expression of the farAB operon is modulated by MtrR in gonococci. We identified a regulatory protein belonging to the MarR family of transcriptional repressors and found that it negatively controls expression of farAB by directly binding to the farAB promoter. We designated this regulator FarR to signify its role in regulating the farAB operon. We found that MtrR binds to the farR promoter, thereby repressing farR expression. Hence, MtrR regulates farAB in a positive fashion by modulating farR expression. This MtrR regulatory cascade seems to play an important role in adjusting levels of the FarAB and MtrCDE efflux pumps to prevent their excess expression in gonococci.

Enhanced expression of the nuclear envelope LAP2 transcriptional repressors in normal and malignant activated lymphocytes

2007 ◽  
Vol 86 (6) ◽  
pp. 393-401 ◽  
Author(s):  
Raz Somech ◽  
Einav Nili Gal-Yam ◽  
Sigal Shaklai ◽  
Orit Geller ◽  
Ninette Amariglio ◽  
...  
Keyword(s):  
Nuclear Envelope ◽  
Transcriptional Repressors ◽  
Activated Lymphocytes ◽  
Enhanced Expression

In silico identification and characterization of sensory motifs in the transcriptional regulators of the ArsR-SmtB family

Metallomics ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1476-1500 ◽  
Author(s):  
Rima Roy ◽  
Saikat Samanta ◽  
Surajit Patra ◽  
Nav Kumar Mahato ◽  
Rudra P. Saha
Keyword(s):  
In Silico ◽  
Transcriptional Regulators ◽  
Transcriptional Repressors ◽  
Structural Elements ◽  
In Silico Identification ◽  
Metal Efflux ◽  
Identification And Characterization ◽  
Secondary Structural Elements ◽  
Efflux Proteins

The ArsR-SmtB family of transcriptional repressors regulates the transcription of metal-efflux proteins by binding specific metals at a variety of secondary structural elements, called motifs, on the surface of the proteins.

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