Synthesis of Tetrahydropyran-2-carboxylic Acid Derivatives of Lipid A Containing an Olefin in Their Chains and Their LPS-Antagonistic Activities

2003 ◽  
Vol 76 (12) ◽  
pp. 2341-2352 ◽  
Author(s):  
Yukiko Watanabe ◽  
Masao Shiozaki ◽  
Daisuke Tanaka ◽  
Takaichi Shimozato ◽  
Saori Kanai ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Lipid A ◽  
Derivatives Of

scholarly journals Novel Derivatives of 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid Hydrazide: Synthesis, Lipophilicity, and In Vitro Antimicrobial Activity Screening

2021 ◽  
Vol 11 (3) ◽  
pp. 1180
Author(s):  
Kinga Paruch ◽  
Łukasz Popiołek ◽  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Malm ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Bacterial Infections ◽  
Acid Hydrazide ◽  
Antimicrobial Effect ◽  
In Vitro Antimicrobial Activity ◽  
Research Goal ◽  
New Compounds ◽  
Derivatives Of

Bacterial infections, especially those caused by strains resistant to commonly used antibiotics and chemotherapeutics, are still a current threat to public health. Therefore, the search for new molecules with potential antimicrobial activity is an important research goal. In this article, we present the synthesis and evaluation of the in vitro antimicrobial activity of a series of 15 new derivatives of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid. The potential antimicrobial effect of the new compounds was observed mainly against Gram-positive bacteria. Compound 15, with the 5-nitro-2-furoyl moiety, showed the highest bioactivity: minimum inhibitory concentration (MIC) = 1.95–15.62 µg/mL and minimum bactericidal concentration (MBC)/MIC = 1–4 µg/mL.

scholarly journals Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4

2008 ◽  
Vol 6 (18) ◽  
pp. 3371 ◽  
Author(s):  
Yanghui Zhang ◽  
Jidnyasa Gaekwad ◽  
Margreet A. Wolfert ◽  
Geert-Jan Boons
Keyword(s):  
Porphyromonas Gingivalis ◽  
Lipid A ◽  
Derivatives Of

Some Basic Derivatives of 3-Methylflavone-8-carboxylic Acid

1960 ◽  
Vol 2 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Paolo Da Re ◽  
Lucia Verlicchi ◽  
Ivo Setnikar
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

scholarly journals Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

Molecules ◽  
2006 ◽  
Vol 11 (12) ◽  
pp. 968-977 ◽  
Author(s):  
Mario Sechi ◽  
Fabio Casu ◽  
Ilaria Campesi ◽  
Stefano Fiori ◽  
Alberto Mariani
Keyword(s):  
Carboxylic Acid ◽  
Antiviral Activity ◽  
Molecular Structures ◽  
Derivatives Of

Heterocycles from 2-Aminopyridine and Derivatives of 3-Methylbenzofuran-2-carboxylic Acid

Heterocycles ◽  
1997 ◽  
Vol 45 (4) ◽  
pp. 787 ◽  
Author(s):  
Yvette A. Jackson ◽  
Mark F. Williams
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

Aminoalkyl derivatives of 2,4′-bithiazole-4-carboxylic acid, the intercalating part of bleomycin

1984 ◽  
Vol 21 (3) ◽  
pp. 681-683 ◽  
Author(s):  
Raymond Houssin ◽  
Jean-Luc Bernier ◽  
Jean-Pierre Hénichart
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

Carboxylic acid and phosphate ester derivatives of fluconazole: synthesis and antifungal activities

2004 ◽  
Vol 12 (23) ◽  
pp. 6255-6269 ◽  
Author(s):  
Nguyen-Hai Nam ◽  
Soroush Sardari ◽  
Meredith Selecky ◽  
Keykavous Parang
Keyword(s):  
Carboxylic Acid ◽  
Phosphate Ester ◽  
Antifungal Activities ◽  
Derivatives Of
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