Crystalline-State Reaction of Cobaloxime Complexes. 19. A New Mode of Racemization of the 1-Cyanoethyl Group

1996 ◽  
Vol 69 (9) ◽  
pp. 2425-2433 ◽  
Author(s):  
Yoshiki Ohgo ◽  
Yuji Ohashi
Keyword(s):  
Crystalline State ◽  
Cyanoethyl Group

Crystalline-state racemization of a chiral cyanoethyl group connected by a hydrogen bond

1993 ◽  
Vol 49 (2) ◽  
pp. 272-277 ◽  
Author(s):  
Y. Takenaka ◽  
Y. Ohashi ◽  
T. Tamura ◽  
A. Uchida ◽  
Y. Sasada ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Crystalline State ◽  
Cyanoethyl Group

Self-Assembly Optical Components

2003 ◽  
Vol 771 ◽  
Author(s):  
Pavel I. Lazarev ◽  
Michael V. Paukshto ◽  
Elena N. Sidorenko
Keyword(s):  
Optical Properties ◽  
Self Assembly ◽  
Crystalline State ◽  
Liquid Crystalline ◽  
Film Deposition ◽  
X Ray Diffraction ◽  
Optical Components ◽  
Crystal Film ◽  
Solid Film ◽  
Thin Crystal

AbstractWe report a new method of Thin Crystal Film deposition. In the present paper we describe the method of crystallization, structure, and optical properties of Bisbenzimidazo[2,1-a:1',2',b']anthra[2,1,9-def:6,5,10-d'e'f']-diisoquinoline-6,9-dion (mixture with cis-isomer) (abbreviated DBI PTCA) sulfonation product. The Thin Crystal Film has a thickness of 200-1000 nm, with anisotropic optical properties such as refraction and absorption indices. X-ray diffraction data evidences a lyotropic liquid crystalline state in liquid phase and crystalline state in solid film. Anisotropic optical properties of the film make it useful in optical devices, e.g. liquid crystal displays.

scholarly journals Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4481
Author(s):  
Meng Cheng ◽  
Qiaoming Liu ◽  
Tiantian Gan ◽  
Yuanying Fang ◽  
Pengfei Yue ◽  
...  
Keyword(s):  
Thin Film ◽  
Retention Time ◽  
Blood Circulation ◽  
Crystalline State ◽  
Circulation System ◽  
Particle Sizes ◽  
High Pressure Homogenization ◽  
Rapid Dissolution ◽  
Efficient Route

Prolonging in vivo circulation has proved to be an efficient route for enhancing the therapeutic effect of rapidly metabolized drugs. In this study, we aimed to construct a nanocrystal-loaded micelles delivery system to enhance the blood circulation of docetaxel (DOC). We employed high-pressure homogenization to prepare docetaxel nanocrystals (DOC(Nc)), and then produced docetaxel nanocrystal-loaded micelles (DOC(Nc)@mPEG-PLA) by a thin-film hydration method. The particle sizes of optimized DOC(Nc), docetaxel micelles (DOC@mPEG-PLA), and DOC(Nc)@mPEG-PLA were 168.4, 36.3, and 72.5 nm, respectively. The crystallinity of docetaxel was decreased after transforming it into nanocrystals, and the crystalline state of docetaxel in micelles was amorphous. The constructed DOC(Nc)@mPEG-PLA showed good stability as its particle size showed no significant change in 7 days. Despite their rapid dissolution, docetaxel nanocrystals exhibited higher bioavailability. The micelles prolonged the retention time of docetaxel in the circulation system of rats, and DOC(Nc)@mPEG-PLA exhibited the highest retention time and bioavailability. These results reveal that constructing nanocrystal-loaded micelles may be a promising way to enhance the in vivo circulation and bioavailability of rapidly metabolized drugs such as docetaxel.

scholarly journals Selective Ion Exchange in Supramolecular Channels in the Crystalline State

2019 ◽  
Vol 58 (13) ◽  
pp. 4169-4172 ◽  
Author(s):  
Katsuya Ichihashi ◽  
Daisuke Konno ◽  
Kseniya Yu. Maryunina ◽  
Katsuya Inoue ◽  
Kazuhiro Toyoda ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Crystalline State
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