ENDOR Study of the Cation Radicals of Vitamin E Derivatives. Relation between Antioxidant Activity and Molecular Structure

1992 ◽  
Vol 65 (8) ◽  
pp. 2016-2020 ◽  
Author(s):  
Kazuo Mukai ◽  
Yuichi Uemoto ◽  
Masami Fukuhara ◽  
Shin-ichi Nagaoka ◽  
Kazuhiko Ishizu
Keyword(s):  
Molecular Structure ◽  
Antioxidant Activity ◽  
Vitamin E ◽  
Cation Radicals

X-Ray Crystallographic Studies of Vitamin E Derivatives. Relationship between Antioxidant Activity and Molecular Structure

1993 ◽  
Vol 66 (12) ◽  
pp. 3808-3810 ◽  
Author(s):  
Kazuo Mukai ◽  
Shigeru Ohbayashi ◽  
Shin-ichi Nagaoka ◽  
Takehiro Ozawa ◽  
Nagao Azuma
Keyword(s):  
Molecular Structure ◽  
Antioxidant Activity ◽  
Vitamin E ◽  
X Ray

scholarly journals Effect of phytyl side chain of vitamin E on its antioxidant activity.

1985 ◽  
Vol 260 (4) ◽  
pp. 2191-2196
Author(s):  
E Niki ◽  
A Kawakami ◽  
M Saito ◽  
Y Yamamoto ◽  
J Tsuchiya ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Side Chain

Influence of vitamin E on gastric mucosal antioxidant activity in chronic gastritis

1993 ◽  
Vol 2 (Supplement) ◽  
pp. 22 ◽  
Author(s):  
I Beno ◽  
L Koszeghyová ◽  
K Volkovová ◽  
M Staruchová
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Chronic Gastritis

Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats

2008 ◽  
Vol 19 (7) ◽  
pp. 467-474 ◽  
Author(s):  
Clement K. Ameho ◽  
C.-Y. Oliver Chen ◽  
Donald Smith ◽  
Concepción Sánchez-Moreno ◽  
Paul E. Milbury ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Metabolite Profile

The extraordinary antioxidant activity of vitamin E phosphate

2004 ◽  
Vol 1683 (1-3) ◽  
pp. 16-21 ◽  
Author(s):  
Bashir M Rezk ◽  
Guido R.M.M Haenen ◽  
Wim J.F van der Vijgh ◽  
Aalt Bast
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E

Evidence of Trolox and some gallates as synergistic protectors of erythrocytes against peroxyl radicals

1998 ◽  
Vol 76 (4) ◽  
pp. 661-664 ◽  
Author(s):  
J Wu ◽  
H Sugiyama ◽  
L -H Zeng ◽  
D Mickle ◽  
T -W Wu
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Protective Effect ◽  
Propyl Gallate ◽  
Peroxyl Radical ◽  
Human Erythrocytes ◽  
Peroxyl Radicals ◽  
Methyl Ethyl ◽  
Radical Initiator ◽  
Individual Contributions

The peroxidation of human erythrocytes induced by peroxyl radical initiator and its inhibition by several gallate esters (e.g., propyl, methyl, ethyl) and Trolox (a more polar analogue of vitamin E) have been studied. The antioxidant activity was determined on erythrocytes against hemolysis generated by a thermal activator, 2,2prime-azobis-(2-amidinopropane)dihydrogenchloride. It was found that propyl gallate and its two analogues were more effective than Trolox in preventing cell lysis. However, the combination of gallate esters and Trolox produced a protective effect exceeding the arithmetic sum of their individual contributions. These perceived synergisms occur at more than one level of Trolox at a given level of a gallate ester.Key words: Trolox, gallates, synergism, peroxyl radicals.

scholarly journals Concentration Dependence of the Antioxidant and Prooxidant Activity of Trolox in HeLa Cells: Involvement in the Induction of Apoptotic Volume Decrease

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1058
Author(s):  
Maria Elena Giordano ◽  
Roberto Caricato ◽  
Maria Giulia Lionetto
Keyword(s):  
Antioxidant Activity ◽  
Vitamin E ◽  
Concentration Dependence ◽  
Hela Cells ◽  
Prooxidant Activity ◽  
Prooxidant Effect ◽  
Apoptotic Process ◽  
Apoptotic Volume Decrease ◽  
Dose Dependent ◽  
Volume Decrease

Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), a hydrophilic analog of vitamin E, is known for its strong antioxidant activity, being a high radical scavenger of peroxyl and alkoxyl radicals. Under particular conditions, Trolox may also exhibit prooxidant properties. The present work aimed at studying the dual antioxidant/prooxidant behavior of Trolox over a wide range of concentrations (from 2.5 to 160 µM) in HeLa cells. In particular, the study addressed the dose-dependent effects of Trolox on the oxidative cell status and vitality of HeLa cells, focusing on the potential role of the vitamin E analog in the induction of one of the first steps of the apoptotic process, Apoptotic Volume Decrease (AVD). In HeLa cells, Trolox showed significant antioxidant activity, expressed as the ability to reduce the endogenous ROS production detected by the ROS-sensitive probe 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate (CM-H2DCFDA), at low concentrations (range: 2.5–15 µM), but exerted a dose-dependent prooxidant effect at higher concentrations after 24 h exposure. The prooxidant effect was paralleled by the reduction in cell viability due to the induction of the apoptotic process. The dual behavior, antioxidant at lower concentrations and prooxidant at higher concentrations, was evident also earlier after 2 h incubation, and it was paralleled by the isotonic shrinkage of the cells, ascribed to AVD. The use of SITS, known Cl− channel blocker, was able to completely inhibit the Trolox-induced isotonic cell shrinkage, demonstrating the involvement of the vitamin E analog in the alteration of cell volume homeostasis and, in turn, in the AVD induction. In conclusion, the study shed light on the concentration dependence of the Trolox antioxidant/prooxidant activity in HeLa cells and revealed its role in the induction of one of the first events of apoptosis, AVD, at high concentrations.

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