scholarly journals On the Relationship between the Chemical Structure and the Cyclic AMP Phosphodiesterase Inhibitory Activity of Flavonoids as Studied by13C NMR

1989 ◽  
Vol 62 (8) ◽  
pp. 2450-2454 ◽  
Author(s):  
Yohko Sakamoto ◽  
Taichi Ohmoto ◽  
Tamotsu Nikaido ◽  
Kazuo Koike ◽  
Tsuyoshi Tomimori ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Inhibitory Activity ◽  
Chemical Structure ◽  
Cyclic Amp Phosphodiesterase ◽  
The Relationship

scholarly journals Cyclic AMP Phosphodiesterase Inhibitory Activity and Chemical Screening of Four Medicinal Plants

2001 ◽  
Vol 39 (3) ◽  
pp. 181-183 ◽  
Author(s):  
Khin Chit ◽  
Win Myint ◽  
Kyi Thein ◽  
Win Win Maw ◽  
Mar Mar Myint ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Cyclic Amp ◽  
Inhibitory Activity ◽  
Chemical Screening ◽  
Cyclic Amp Phosphodiesterase

scholarly journals Synthesis and Cyclic AMP Phosphodiesterase 4 Isoenzyme Inhibitory Activity of Heterocycle Condensed Purines

2002 ◽  
Vol 50 (9) ◽  
pp. 1163-1163 ◽  
Author(s):  
Hirokazu Suzuki ◽  
Manabu Yamamoto ◽  
Susumu Shimura ◽  
Ken-ichi Miyamoto ◽  
Kenji Yamamoto ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Inhibitory Activity ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase

Steroidal saponins from Nolina recurvata stems and their inhibitory activity on cyclic AMP phosphodiesterase

1996 ◽  
Vol 42 (6) ◽  
pp. 1609-1615 ◽  
Author(s):  
Yoshihiro Mimaki ◽  
Yoko Takaashi ◽  
Minpei Kuroda ◽  
Yutaka Sashida ◽  
Tamotsu Nikaido
Keyword(s):  
Cyclic Amp ◽  
Inhibitory Activity ◽  
Steroidal Saponins ◽  
Cyclic Amp Phosphodiesterase

Cyclic AMP Phosphodiesterase 4 Isoenzyme Inhibitory Activity of (R)- and (S)-Isomer of 7-Methyl- or 8-Alkyl-4,5,7,8-tetrahydroimidazo[2,1-i]- purin-5-one

2004 ◽  
Vol 27 (3) ◽  
pp. 357-360 ◽  
Author(s):  
Hirokazu Suzuki ◽  
Masaaki Nomura ◽  
Ken-ichi Miyamoto ◽  
Hiroyuki Sawanishi ◽  
Kenji Yamamoto
Keyword(s):  
Cyclic Amp ◽  
Inhibitory Activity ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase

The Effect of Mitomycin C on Platelet Aggregation and Adenosine 3′, 5′-Monophosphate Metabolism

1978 ◽  
Vol 39 (01) ◽  
pp. 177-185 ◽  
Author(s):  
Shuichi Hashimoto ◽  
Sachiko Shibata ◽  
Bonro Kobayashi
Keyword(s):  
Platelet Aggregation ◽  
Cyclic Amp ◽  
Mitomycin C ◽  
Blood Platelets ◽  
Adenosine Diphosphate ◽  
Cellular Membrane ◽  
Adenyl Cyclase ◽  
Cyclic Amp Phosphodiesterase ◽  
Membrane Structure And Function ◽  
And Function

SummaryThe effect of Mitomycin C on aggregation, adenosine 3′, 5′-monophosphate (cyclic AMP) metabolism and reactions induced by thrombin was studied in rabbit platelets. Mitomycin C inhibited the platelet aggregation induced by adenosine diphosphate or thrombin. The level of radioactive cyclic AMP derived from 8-14C adenine or 8-14C adenosine increased after incubating intact platelets with Mitomycin G. Formation of radioactive adenosine triphosphate also increased though mitochondrial oxidation was not stimulated. Similar effect was observed also in rabbit liver. Mitomycin C failed to stimulate platelet adenyl cyclase but inhibited cyclic AMP phosphodiesterase in the absence of theophylline. In the platelets preincubated with Mitomycin C, thrombin-induced inhibition of adenyl cyclase, stimulation of membrane-bound cyclic AMP phosphodiesterase, and release of 250,000 dalton protein from platelet membranes were prevented. These results suggest that Mitomycin C will affect cellular membrane structure and function, and this extranuclear effect of Mitomycin C will lead to inhibition of aggregation in blood platelets.

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