scholarly journals CD Spectra of 2,4-Dinitrophenyl Derivatives of α-Amino Acids Having Polynuclear Aromatic Group in the Side Chain. Absolute Configuration of 3-(9-Anthryl)alanine

1985 ◽  
Vol 58 (10) ◽  
pp. 3047-3048 ◽  
Author(s):  
Masao Kawai ◽  
Taketoshi Matsuura ◽  
Yasuo Butsugan ◽  
Syun Egusa ◽  
Masahiko Sisido ◽  
...  
Keyword(s):  
Amino Acids ◽  
Absolute Configuration ◽  
Side Chain ◽  
Cd Spectra ◽  
Aromatic Group ◽  
Derivatives Of

Absolute configuration at C(20) of the derivatives of 21-nor-5α-cholane-20,24-diol

1980 ◽  
Vol 45 (9) ◽  
pp. 2443-2451
Author(s):  
Vladimír Pouzar ◽  
Miroslav Havel
Keyword(s):  
Absolute Configuration ◽  
Side Chain ◽  
Chemical Correlation ◽  
The Absolute ◽  
Derivatives Of

Derivatives of 21-nor-5α-cholane-20,24-diol XI and XIX were prepared by stepwise construction of the side-chain in the position 17β. Their absolute configuration at C(20) was determined on the basis of chemical correlation with the derivatives of 21-nor-5α-cholan-20-ol, XVI and XXIV. The absolute configuration of alcohols XVI and XXIV was determined from the ratio of the yields in which they are formed during the reduction of ketone X and using the benzoate rule. To compounds XI-XVIII the configuration 20R and to compounds XIX-XXVI the configuration 20S has been assigned.

X-ray crystal structure analysis of a bisepoxide derived from secologanin: the structure and absolute configuration

1983 ◽  
Vol 61 (2) ◽  
pp. 282-283 ◽  
Author(s):  
Stanley C. Nyburg ◽  
Pik Y. Siew ◽  
Gavin N. Saunders ◽  
John R. Purdy ◽  
Stewart McLean
Keyword(s):  
Crystal Structure ◽  
Structure Analysis ◽  
Absolute Configuration ◽  
Dimethyl Acetal ◽  
Crystal Structure Analysis ◽  
Side Chain ◽  
Bench Mark ◽  
Chemical Transformations ◽  
X Ray ◽  
Derivatives Of

The structure and absolute configuration of a bisepoxide (2) produced by oxidation of tetraacetylsecologanin dimethyl acetal (1) with m-chloroperbenzoic acid have been established by X-ray crystal structure analysis. Epoxidation of the vinyl side chain is unexceptional; epoxidation of the β-alkoxyacrylate moiety is novel. This determination represents a valuable bench mark for configurational assignments, since the bisepoxide has been correlated by chemical transformations with a number of synthetic and naturally-occurring derivatives of secologanin.

The relation between cd spectra of n-dithioethoxycarbonyl derivatives of β-amino acids and their configurations

1978 ◽  
Vol 19 (21) ◽  
pp. 1813-1816 ◽  
Author(s):  
Takashi Yamada ◽  
Shigeru Kuwata ◽  
Hiroshi Watanabe
Keyword(s):  
Amino Acids ◽  
Cd Spectra ◽  
Derivatives Of

scholarly journals Synthesis of enantiomerically enriched (R)-13C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine

2011 ◽  
Vol 7 ◽  
pp. 1304-1309 ◽  
Author(s):  
Stephen P Fletcher ◽  
Jordi Solà ◽  
Dean Holt ◽  
Robert A Brown ◽  
Jonathan Clayden
Keyword(s):  
Amino Acids ◽  
Absolute Configuration ◽  
Enantiomeric Purity ◽  
Methyl Groups ◽  
Aminoisobutyric Acid ◽  
The Absolute ◽  
Conformational Memory ◽  
Enantioselective Alkylation ◽  
Derivatives Of

The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N-naphthoyl derivatives of amino acids was used to introduce a 13C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive alkylation of L-alanine with 13CH3I. Conditions were identified for optimization of yield and enantiomeric purity, and the absolute configuration of the labelled product was established.

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