scholarly journals Solid Phase Peptide Synthesis by Oxidation-Reduction Condensation. Synthesis of Adrenocorticotropin(1–24) by Chain Elongation at the Carboxyl End on Solid Support

1976 ◽  
Vol 49 (8) ◽  
pp. 2259-2267 ◽  
Author(s):  
Hiroshi Maruyama ◽  
Rei Matsueda ◽  
Eiichi Kitazawa ◽  
Hidekuni Takahagi ◽  
Teruaki Mukaiyama
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solid Support ◽  
Chain Elongation ◽  
Oxidation Reduction

scholarly journals Solid Phase Peptide Synthesis by Oxidation-Reduction Condensation. Synthesis of LH–RH by Fragment Condensation on Solid Support

1973 ◽  
Vol 46 (10) ◽  
pp. 3240-3247 ◽  
Author(s):  
Rei Matsueda ◽  
Hiroshi Maruyama ◽  
Eiichi Kitazawa ◽  
Hidekuni Takahagi ◽  
Teruaki Mukaiyama
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solid Support ◽  
Oxidation Reduction ◽  
Fragment Condensation ◽  
Lh Rh

scholarly journals Serine promoted synthesis of peptide thioester-precursor on solid support for native chemical ligation

2017 ◽  
Vol 8 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Hader E. Elashal ◽  
Yonnette E. Sim ◽  
Monika Raj
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solid Support ◽  
Native Chemical Ligation ◽  
Selective Activation ◽  
Chemical Ligation ◽  
Peptide Thioester ◽  
Peptide Thioesters

Fmoc solid phase peptide synthesis of peptide thioesters by displacement of the cyclic urethane moiety obtained by the selective activation of C-terminal serine.

Solid phase peptide synthesis by oxidation-reduction condensation

1975 ◽  
Vol 97 (9) ◽  
pp. 2573-2575 ◽  
Author(s):  
Rei Matsueda ◽  
Hiroshi Maruyama ◽  
Eiichi Kitazawa ◽  
Hidekuni Takahagi ◽  
Teruaki Mukaiyama
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Oxidation Reduction

OctaGel Resin - A New PEG-PS-based Solid Support for Solid-Phase Peptide Synthesis

2019 ◽  
Vol 16 (12) ◽  
pp. 935-940
Author(s):  
Shaveer Ramkisson ◽  
Yahaya E. Jad ◽  
Anamika Sharma ◽  
Beatriz G. de la Torre ◽  
Fernando Albericio
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solid Support ◽  
Bead Size ◽  
Swelling Capacity ◽  
Surface Active

: OctaGel resin is a unique, highly uniformed surface-active resin. Here, we compared the performance of OctaGel with that of known resins on the market, namely polystyrene and ChemMatrix, in Solid-Phase Peptide Synthesis. The synthesis of the ‘difficult’ Aib-ACP (65-74) decapeptide showed that OctaGel has the potential to yield molecules with satisfactory purity. Given its high swelling capacity and large bead size, OctaGel also shows efficient interaction with various solvents, including those mainly used for SPPS (DMF and DCM).

scholarly journals Stirring Peptide Synthesis to a New Level of Efficiency

2021 ◽  
Author(s):  
Johnny N Naoum ◽  
Israel Alshanski ◽  
Guy Mayer ◽  
Poriah Strauss ◽  
Mattan Hurevich
Keyword(s):  
Elevated Temperature ◽  
Peptide Synthesis ◽  
State Of The Art ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solid Support ◽  
The State ◽  
Large Excess

In this work, a new setup that relies on fast stirring and heating was used to increase the diffusion of both reagents and solid support. we show that the combination of fast mixing and elevated temperature enables the acceleration of solid-phase peptide synthesis without using a large excess of reagents, providing a greener and accessible alternative to the state-of-the-art.<br>

scholarly journals Convergent Synthesis of Thioether Containing Peptides

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 218
Author(s):  
Spyridon Mourtas ◽  
Christina Katakalou ◽  
Dimitrios Gatos ◽  
Kleomenis Barlos
Keyword(s):  
Carboxylic Acids ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Building Blocks ◽  
Solid Support ◽  
Convergent Synthesis ◽  
Fmoc Group ◽  
Synthetic Routes ◽  
Peptide Elongation

Thioether containing peptides were obtained following three synthetic routes. In route A, halo acids esterified on 2-chlorotrityl(Cltr) resin were reacted with N-fluorenylmethoxycarbonyl (Fmoc) aminothiols. These were either cleaved from the resin to the corresponding (Fmoc-aminothiol)carboxylic acids, which were used as key building blocks in solid phase peptide synthesis (SPPS), or the N-Fmoc group was deprotected and peptide chains were elongated by standard SPPS. The obtained N-Fmoc protected thioether containing peptides were then condensed either in solution, or on solid support, with the appropriate amino components of peptides. In route B, the thioether containing peptides were obtained by the reaction of N-Fmoc aminothiols with bromoacetylated peptides, which were synthesized on Cltr-resin, followed by removal of the N-Fmoc group and subsequent peptide elongation by standard SPPS. In route C, the thioether containing peptides were obtained by the condensation of a haloacylated peptide synthesized on Cltr-resin and a thiol-peptide synthesized either on 4-methoxytrityl(Mmt) or trityl(Trt) resin.

ChemInform Abstract: SOLID PHASE PEPTIDE SYNTHESIS BY OXIDATION-REDUCTION CONDENSATION

1975 ◽  
Vol 6 (29) ◽  
pp. no-no
Author(s):  
REI MATSUEDA ◽  
HIROSHI MARUYAMA ◽  
EIICHI KITAZAWA ◽  
HIDEKUNI TAKAHAGI ◽  
TERUAKI MUKAIYAMA
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Oxidation Reduction
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