scholarly journals Metal Complexes of EDTA and Its Related Compounds. I. Geometric Isomers of [Co(X)(N-methyl-trimethylenediamine-N,N′,N′-triacetate)] Complexes with X=H2O, NH3, Cl−or CN−

1975 ◽  
Vol 48 (3) ◽  
pp. 874-878 ◽  
Author(s):  
Myung-Ki Doh ◽  
Junnosuke Fujita ◽  
Hiroshi Ogino ◽  
Kazuo Saito
Keyword(s):  
Metal Complexes ◽  
Geometric Isomers ◽  
Related Compounds

Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds

1983 ◽  
Vol 48 (2) ◽  
pp. 623-641 ◽  
Author(s):  
Zdeněk Polívka ◽  
Miroslav Rajšner ◽  
Jan Metyš ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Sulfuric Acid ◽  
Title Compound ◽  
Amino Alcohol ◽  
Hydrogen Sulfate ◽  
Geometric Isomers ◽  
Pure Alcohol ◽  
Acid Catalyzed ◽  
Anticataleptic Activity ◽  
Related Compounds

In the reaction of thieno[2,3c]-2-benzothiepin-4(9H)-one (VI) with 1-methyl-4-piperidylmagnesium chloride 7-(1-methyl-4-piperidyl)thieno[2,3-c]-2-benzothiepin-4(9H)-one (VIII) is formed in addition to the expected amino alcohol VII. The title compound I was obtained by the acid catalyzed dehydration of the pure alcohol VII. Compound I (pipethiadene) has outstanding antihistamine, antiserotonin, antireserpine and anticataleptic activity and was recommended to clinical trials as a potential antimigraine agent. For pharmacokinetic and metabolic studies there were prepared the NC2H3 analogue of pipethiadene IV and further, as potential metabolites, the demethyl analogue III, S-oxide X, demethyl S-oxide XI, N-oxide XIII and N,S-dioxide XIV. The Witting reaction of the ketone VI with 3-dimethylaminopropylidenetriphenylphosphorane resulted in a mixture of geometric isomers of 4-(3-dimethylamino-propylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin with the strongly predominating Z-isomer XVI which was isolated from the mixture by crystallization of the hydrogen maleate. The mixture with the predominating Z-isomer XVI was converted by the treatment with 80% sulfuric acid and dilution with water to a mixture with the predominating E-isomer XV (dithiadene) which was isolated by crystallization of the hydrogen sulfate. Some further new thieno[2,3-c]-2-benzothiepin derivatives were synthesized as potential intermediates.

scholarly journals The Metal Complexes of Peptides and Related Compounds

1968 ◽  
Vol 243 (11) ◽  
pp. 3038-3050 ◽  
Author(s):  
R Österberg ◽  
B Sjöberg
Keyword(s):  
Metal Complexes ◽  
Related Compounds

ChemInform Abstract: Phthalocyanines and Related Compounds. Part 27. Metal Complexes of Octa-tertbutyl-tetra-2,3-triptyceneporphyrazine.

1986 ◽  
Vol 17 (37) ◽  
Author(s):  
T. A. SHATSSKAYA ◽  
M. G. GAL'PERN ◽  
V. R. SKVARCHENKO ◽  
E. A. LUK'YANETS
Keyword(s):  
Metal Complexes ◽  
Related Compounds
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