scholarly journals Catalysis in Peptide Synthesis with Active Esters. II. Effects of Concentrated Carboxylic Acids on the Aminolysis of Benzyloxycarbonyl-L-phenylalaninep-Nitrophenyl Ester in Dioxane

1969 ◽  
Vol 42 (4) ◽  
pp. 1078-1082 ◽  
Author(s):  
Nobuhiro Nakamizo
Keyword(s):  
Carboxylic Acids ◽  
Peptide Synthesis ◽  
Active Esters ◽  
Nitrophenyl Ester

Series of sequential polypeptides containing lysine or arginine: Preparation and characterization

1988 ◽  
Vol 53 (1) ◽  
pp. 145-156 ◽  
Author(s):  
Jana Pírková ◽  
Svetlana Churkina ◽  
Vladimír Gut ◽  
Ivo Frič ◽  
Karel Bláha
Keyword(s):  
Molecular Weight ◽  
Amino Acid ◽  
Peptide Synthesis ◽  
Average Molecular Weight ◽  
Basic Amino Acid ◽  
Cd Spectra ◽  
Active Esters ◽  
Marked Tendency

The sequential polypeptides (Lys-Ala)n, (Lys-Ala-Ala)n, (Lys-Ala-Ala-Ala)n, (Lys-Leu-Ala)n, (Lys-Leu-Ala-Ala)n, (Lys-Leu-Ala-Ala-Ala)n, (Lys-Ala-Leu)n, (Lys-Ala-Leu-Ala)n, (Orn-Leu-Ala)n,(Arg-Ala-Ala)n, (Arg-Leu-Ala)n, (Arg-Leu-Ala-Ala)n, (Arg-Ala-Leu)n, and (Arg-Ala-Leu-Ala)n were synthesized by polymerization of active esters (1-succinimidyl or pentafluorophenyl) of the corresponding Nα-deblocked monomers. The monomers were prepared using the usual methods of peptide synthesis in solution. Upon dialysis, the average molecular weight of the polymer was 6 000-9 000 as determined by sedimentation in ultracentrifuge. Polypeptides, containing leucine in addition to the basic amino acid, showed a marked tendency to aggregation. CD spectra of the products were measured for characterization.

ChemInform Abstract: RIGID ACTIVE ESTERS IN PEPTIDE SYNTHESIS

1974 ◽  
Vol 5 (24) ◽  
pp. no-no
Author(s):  
MIKLOS BODANSZKY ◽  
MARY LYNN FINK ◽  
KENNETH W. FUNK ◽  
MICHIO KONDO ◽  
CYNTHIA YANG LIN ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Active Esters
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