scholarly journals Chemical Synthesis ofO-Ethyl-L-homoserine, a New Amino Acid Produced byCorynebacterium Ethanolaminophilum

1968 ◽  
Vol 41 (3) ◽  
pp. 633-635 ◽  
Author(s):  
Yoshikatsu Murooka ◽  
Tokuya Harada ◽  
Yoshiharu Izumi
Keyword(s):  
Amino Acid ◽  
Chemical Synthesis

scholarly journals Engineering bromodomains with a photoactive amino acid by engaging ‘Privileged’ tRNA synthetases

2020 ◽  
Vol 56 (25) ◽  
pp. 3641-3644
Author(s):  
Shana Wagner ◽  
Babu Sudhamalla ◽  
Philip Mannes ◽  
Sushma Sappa ◽  
Sam Kavoosi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chemical Synthesis ◽  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Site Specific ◽  
Trna Synthetases

An improved chemical synthesis, site-specific incorporation and enhanced photo-crosslinking ability of tmdF have been demonstrated in the context of protein–protein interactions.

scholarly journals A Threonine‐Forming Oxazetidine Amino Acid for the Chemical Synthesis of Proteins through KAHA Ligation

2019 ◽  
Vol 58 (36) ◽  
pp. 12599-12603 ◽  
Author(s):  
Simon Baldauf ◽  
Dominik Schauenburg ◽  
Jeffrey W. Bode
Keyword(s):  
Amino Acid ◽  
Chemical Synthesis

scholarly journals Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide–membrane interactions

2019 ◽  
Vol 55 (35) ◽  
pp. 5095-5098 ◽  
Author(s):  
Kui Zhang ◽  
Ismail A. Ahmed ◽  
Huong T. Kratochvil ◽  
William F. DeGrado ◽  
Feng Gai ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chemical Synthesis ◽  
Membrane Interactions ◽  
Fluorescent Amino Acid

Facile chemical synthesis of l-4CN-Trp and incorporation into a pHLIP peptide enabled FRET study on peptide–membrane interactions.

First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form

1991 ◽  
Vol 180 (2) ◽  
pp. 1010-1018 ◽  
Author(s):  
H. de Rocquigny ◽  
D. Ficheux ◽  
C. Gabus ◽  
M.-C. Fournié-Zaluski ◽  
J.-L. Darlix ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chemical Synthesis ◽  
Nucleocapsid Protein ◽  
Large Scale ◽  
Active Form ◽  
Hiv 1

scholarly journals An OregonGreen488-labelled d-amino acid for visualizing peptidoglycan by super-resolution STED nanoscopy

Microbiology ◽  
2020 ◽  
Vol 166 (12) ◽  
pp. 1129-1135 ◽  
Author(s):  
Bill Söderström ◽  
Alessandro Ruda ◽  
Göran Widmalm ◽  
Daniel O. Daley
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chemical Synthesis ◽  
Super Resolution ◽  
Molecular Probes ◽  
Stimulated Emission ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Peptidoglycan Synthesis ◽  
Peptidoglycan Layer

Fluorescent d-amino acids (FDAAs) are molecular probes that are widely used for labelling the peptidoglycan layer of bacteria. When added to growing cells they are incorporated into the stem peptide by a transpeptidase reaction, allowing the timing and localization of peptidoglycan synthesis to be determined by fluorescence microscopy. Herein we describe the chemical synthesis of an OregonGreen488-labelled FDAA (OGDA). We also demonstrate that OGDA can be efficiently incorporated into the PG of Gram-positive and some Gram-negative bacteria, and imaged by super-resolution stimulated emission depletion (STED) nanoscopy at a resolution well below 100 nm.

scholarly journals Prebiotic Synthesis of Cysteine Peptides That Catalyze Peptide Ligation in Neutral Water

2020 ◽  
Author(s):  
Callum Foden ◽  
Saidul Islam ◽  
Christian Arturo Fernandez Garcia ◽  
Leonardo Maugeri ◽  
Tom Sheppard ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chemical Synthesis ◽  
Prebiotic Synthesis ◽  
Biomimetic Synthesis ◽  
Strecker Reaction ◽  
Simple Chemical ◽  
Peptide Biosynthesis ◽  
Neutral Water ◽  
Life On Earth

<div>Peptides and the proteinogenic α-amino acids are essential to all life on Earth. Peptide biosynthesis is orchestrated by a complex suite of enzymes in extant biology, but this must have been predated by a simple chemical synthesis at the origins of life. α-Aminonitriles, the nitrile precursors of α-amino acids, are generally readily produced by Strecker reactions, but the origin of cysteine—the thiol-bearing amino acid—is not understood. The aminothiol moiety of cysteine is chemically incompatible with nitriles at physiological pH, therefore cysteine nitrile is not stable, and it is widely believed that cysteine was a biological invention and a late addition to the genetic code<sub>.</sub> Here, we report the first high-yielding, prebiotic synthesis of cysteine peptides. Our biomimetic synthesis converts serine to cysteine, by-passing the Strecker reaction of β-mercaptoacetaldehyde, but exploits nitrile–activated dehydroalanine synthesis at near-neutral pH. We additionally demonstrate the catalytic prowess of <i>N</i>-acylcysteines (and related peptides and thiols) in the organocatalytic synthesis of peptides and peptidyl amidines in neutral water. Thiol catalysis directly couples kinetically stable—but energy-rich—α-amidonitriles to proteinogenic amines, in a reaction that tolerates all twenty proteinogenic side chains. This is a rare, prebiotically plausible example of selective and efficient organocatalysis in water. Our results implicate cysteine derivatives and thiol-catalysis at the onset of evolution.</div>

scholarly journals Reactivity and Chemical Synthesis of L-Pyrrolysine— the 22nd Genetically Encoded Amino Acid

2004 ◽  
Vol 11 (9) ◽  
pp. 1317-1324 ◽  
Author(s):  
Bing Hao ◽  
Gang Zhao ◽  
Patrick T. Kang ◽  
Jitesh A. Soares ◽  
Tsuneo K. Ferguson ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chemical Synthesis

Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein

2011 ◽  
Vol 123 (27) ◽  
pp. 6261-6265 ◽  
Author(s):  
K. S. Ajish Kumar ◽  
Sudhir N. Bavikar ◽  
Liat Spasser ◽  
Tal Moyal ◽  
Shimrit Ohayon ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chemical Synthesis
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