scholarly journals Estrogenic Biphenyls. VI. 2- and 6′-Alkyl Derivatives of 3′-Ethyl-4-methoxy-biphenyl-4′-carboxylic Acid

1959 ◽  
Vol 32 (12) ◽  
pp. 1289-1291 ◽  
Author(s):  
Takeo Sato ◽  
Michinori Oki
Keyword(s):  
Carboxylic Acid ◽  
Alkyl Derivatives ◽  
Derivatives Of

SYNTHESIS OF ALKYL DERIVATIVES OF PLUMBAGIN

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (10) ◽  
pp. 62-66
Author(s):  
G.M Ferreira ◽  
◽  
K.S. Laddha
Keyword(s):  
Nmr Spectroscopy ◽  
Carboxylic Acid ◽  
Silver Nitrate ◽  
Vitamin K ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Antithrombotic Agents ◽  
Alkyl Derivatives ◽  
Derivatives Of

A series of alkyl derivatives of plumbagin (2-methyl-5-hydroxy-1,4-naphthoquinone), analogous to Vitamin K, have been synthesized. Plumbagin reacts with carboxylic acid in presence of silver nitrate and ammonium peroxydisulphate to form its alkyl derivatives. The compounds synthesized were characterized by MS, IR, 1 H and 13C-NMR Spectroscopy. The derivatives prepared may find application as antithrombotic agents and may facilitate designing of similar newer analogues.

FORMATION OF UREA IN LIVER HOMOGENATES FROM CITRULLINE AND VARIOUS N-ALKYL DERIVATIVES OF ASPARTIG ACID

1963 ◽  
Vol 41 (1) ◽  
pp. 2297-2305 ◽  
Author(s):  
R. Charbonneau ◽  
L. Berlinguet
Keyword(s):  
Amino Acids ◽  
Carboxylic Acid ◽  
Aspartic Acid ◽  
Metabolic Pathways ◽  
Inhibitory Effect ◽  
Urea Synthesis ◽  
Alkyl Derivatives ◽  
Amino Acid Analogues ◽  
Liver Homogenates ◽  
Derivatives Of

The effects of various N-alkylated derivatives of aspartic acid on the synthesis of urea by rat liver homogenates have been studied. At 5 × 10−3 M concentration, N-methyl, N-ethyl, N-isopropyl, and N-cyclohexyl aspartic acids are not utilized and have no effect on the formation of urea. At this concentration, N-allyl-DL-aspartic acid inhibits the formation of endogenous urea by 77%. At concentrations of 2.5 to 7.5 × 10−2 M, N-methyl, N-ethyl, and N-isopropyl aspartic acids slightly increase the formation of endogenous urea; this is about 15% of the value obtained when aspartic acid alone is added at the same concentration. In the case of simple N-alkylated aspartic acids, liver homogenates are able to cleave the alkylated chain with the result that a small amount of urea synthesis is possible. N-allylaspartic acid totally inhibits the formation of urea from aspartic acid at a relatively low concentration of 6.2 × 10−3 M. N-cyclohexylaspartic acid has also an inhibitory effect which is ten times less pronounced than that of the N-allyl derivative.Natural amino acids such as DL- and L-valine, DL- and L-leucine, DL- and L-lysine, DL-alanine and glycine, at concentrations of 1.2 to 5 × 10−2 M, also inhibit the formation of urea. This inhibition is probably due to the fact that other metabolic pathways, used by these amino acids, have priority over the formation of urea. Amino acid analogues, such as 1-aminocyclopentane carboxylic acid and 1-amino-2-methylcyclopentane-carboxylic acid, do not have any effect on the synthesis of urea.A free amino group in the aspartic acid molecule seems to be essential for the synthesis of argininosuccinic acid.

FORMATION OF UREA IN LIVER HOMOGENATES FROM CITRULLINE AND VARIOUS N-ALKYL DERIVATIVES OF ASPARTIG ACID

1963 ◽  
Vol 41 (11) ◽  
pp. 2297-2305 ◽  
Author(s):  
R. Charbonneau ◽  
L. Berlinguet
Keyword(s):  
Amino Acids ◽  
Carboxylic Acid ◽  
Aspartic Acid ◽  
Metabolic Pathways ◽  
Inhibitory Effect ◽  
Urea Synthesis ◽  
Alkyl Derivatives ◽  
Amino Acid Analogues ◽  
Liver Homogenates ◽  
Derivatives Of

The effects of various N-alkylated derivatives of aspartic acid on the synthesis of urea by rat liver homogenates have been studied. At 5 × 10−3 M concentration, N-methyl, N-ethyl, N-isopropyl, and N-cyclohexyl aspartic acids are not utilized and have no effect on the formation of urea. At this concentration, N-allyl-DL-aspartic acid inhibits the formation of endogenous urea by 77%. At concentrations of 2.5 to 7.5 × 10−2 M, N-methyl, N-ethyl, and N-isopropyl aspartic acids slightly increase the formation of endogenous urea; this is about 15% of the value obtained when aspartic acid alone is added at the same concentration. In the case of simple N-alkylated aspartic acids, liver homogenates are able to cleave the alkylated chain with the result that a small amount of urea synthesis is possible. N-allylaspartic acid totally inhibits the formation of urea from aspartic acid at a relatively low concentration of 6.2 × 10−3 M. N-cyclohexylaspartic acid has also an inhibitory effect which is ten times less pronounced than that of the N-allyl derivative.Natural amino acids such as DL- and L-valine, DL- and L-leucine, DL- and L-lysine, DL-alanine and glycine, at concentrations of 1.2 to 5 × 10−2 M, also inhibit the formation of urea. This inhibition is probably due to the fact that other metabolic pathways, used by these amino acids, have priority over the formation of urea. Amino acid analogues, such as 1-aminocyclopentane carboxylic acid and 1-amino-2-methylcyclopentane-carboxylic acid, do not have any effect on the synthesis of urea.A free amino group in the aspartic acid molecule seems to be essential for the synthesis of argininosuccinic acid.

7-O-Alkyl derivatives of daunomycinone

1984 ◽  
Vol 49 (1) ◽  
pp. 313-319 ◽  
Author(s):  
Věra Přikrylová ◽  
Petr Sedmera ◽  
Josef V. Jizba ◽  
Jindřich Vokoun ◽  
Helena Lipavská ◽  
...  
Keyword(s):  
H Nmr ◽  
Toluenesulfonic Acid ◽  
Alkyl Derivatives ◽  
Derivatives Of

Reaction of daunomycinone (I) with alcohols and p-toluenesulfonic acid produces a mixture (~3 : 1) of its (7S)- and (7R)-O-alkyl derivatives II-IX. According to the 1H NMR evidence, the alicyclic ring exists in the 9H8 conformation in (7R)-O-alkyl derivatives, on the contrary to (7S)-epimers and 7-epi-daunomycinone that adopt the 8H9 conformation.

Polarized fluorescense of alkyl derivatives of fluorescein, MitoFluo and C8-Fl, in solutions with liposomes

2020 ◽  
Author(s):  
D.M. Beltukova ◽  
V.P. Belik ◽  
Y.N. Antonenko ◽  
A.A. Bogdanov ◽  
G.A. Korshunova ◽  
...  
Keyword(s):  
Alkyl Derivatives ◽  
Derivatives Of

scholarly journals Novel Derivatives of 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid Hydrazide: Synthesis, Lipophilicity, and In Vitro Antimicrobial Activity Screening

2021 ◽  
Vol 11 (3) ◽  
pp. 1180
Author(s):  
Kinga Paruch ◽  
Łukasz Popiołek ◽  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Malm ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Bacterial Infections ◽  
Acid Hydrazide ◽  
Antimicrobial Effect ◽  
In Vitro Antimicrobial Activity ◽  
Research Goal ◽  
New Compounds ◽  
Derivatives Of

Bacterial infections, especially those caused by strains resistant to commonly used antibiotics and chemotherapeutics, are still a current threat to public health. Therefore, the search for new molecules with potential antimicrobial activity is an important research goal. In this article, we present the synthesis and evaluation of the in vitro antimicrobial activity of a series of 15 new derivatives of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid. The potential antimicrobial effect of the new compounds was observed mainly against Gram-positive bacteria. Compound 15, with the 5-nitro-2-furoyl moiety, showed the highest bioactivity: minimum inhibitory concentration (MIC) = 1.95–15.62 µg/mL and minimum bactericidal concentration (MBC)/MIC = 1–4 µg/mL.

Synthesis and reactivity of halide, hydride, and alkyl derivatives of (pentamethylcyclopentadienyl)(bisphosphine)iron(II)

1990 ◽  
Vol 9 (1) ◽  
pp. 260-265 ◽  
Author(s):  
Rocco A. Paciello ◽  
Juan M. Manriquez ◽  
John E. Bercaw
Keyword(s):  
Alkyl Derivatives ◽  
Derivatives Of

The Alkyl Derivatives of Halogen Phenols and their Bactericidal Action. II. Bromophenols

1933 ◽  
Vol 55 (11) ◽  
pp. 4657-4662 ◽  
Author(s):  
Emil Klarmann ◽  
Louis W. Gates ◽  
Vladimir A. Shternov ◽  
Philip H. Cox
Keyword(s):  
Bactericidal Action ◽  
Alkyl Derivatives ◽  
Derivatives Of

570. Compounds of potential pharmacological interest. Part IV. Aryl and alkyl derivatives of 1-aminoindane

1956 ◽  
pp. 2928 ◽  
Author(s):  
J. A. Barltrop ◽  
R. M. Acheson ◽  
P. G. Philpott ◽  
K. E. MacPhee ◽  
J. S. Hunt
Keyword(s):  
Alkyl Derivatives ◽  
Pharmacological Interest ◽  
Derivatives Of

Some Basic Derivatives of 3-Methylflavone-8-carboxylic Acid

1960 ◽  
Vol 2 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Paolo Da Re ◽  
Lucia Verlicchi ◽  
Ivo Setnikar
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of
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