Surface Chemistry of Synthetic Protein Analogues. IV. On the Monolayers of Electrolytic Synthetic Polypeptides, Poly-L-Glutamic Acid and the Copolypeptide of L-Lysine, L-Leucine and L-Glutamic Acid

Toshizo Isemura; Kozo Hamaguchi

doi:10.1246/bcsj.27.339

Surface Chemistry of Synthetic Protein Analogues. IV. On the Monolayers of Electrolytic Synthetic Polypeptides, Poly-L-Glutamic Acid and the Copolypeptide of L-Lysine, L-Leucine and L-Glutamic Acid

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.27.339 ◽

1954 ◽

Vol 27 (6) ◽

pp. 339-345 ◽

Cited By ~ 14

Author(s):

Toshizo Isemura ◽

Kozo Hamaguchi

Keyword(s):

Surface Chemistry ◽

Glutamic Acid ◽

Synthetic Protein ◽

Synthetic Polypeptides

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Surface Chemistry of Synthetic Protein Analogues. III. On the Surface Viscosity of Monolayers of Non-electrolytic Synthetic Polypeptides

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.27.125 ◽

1954 ◽

Vol 27 (3) ◽

pp. 125-130 ◽

Cited By ~ 25

Author(s):

Toshizo Isemura ◽

Kozo Hamaguchi

Keyword(s):

Surface Chemistry ◽

Surface Viscosity ◽

Synthetic Protein ◽

Synthetic Polypeptides

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Surface Chemistry of Synthetic Protein Analogues. I. Surface Pressure-Area Relation of Synthetic Polypeptides as the Model of Proteins

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.25.40 ◽

1952 ◽

Vol 25 (1) ◽

pp. 40-45 ◽

Cited By ~ 33

Author(s):

Toshizo Isemura ◽

Kozo Hamaguchi

Keyword(s):

Surface Chemistry ◽

Surface Pressure ◽

Synthetic Protein ◽

Synthetic Polypeptides ◽

Pressure Area

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Surface Chemistry of Synthetic Protein Analogues. V. On the Effect of Salt on the Monolayers of the Copolypeptide of L-Lysine, L-Phenylalanine and L-Glutamic Acid

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.28.9 ◽

1955 ◽

Vol 28 (1) ◽

pp. 9-15 ◽

Cited By ~ 14

Author(s):

Kozo Hamaguchi ◽

Toshizo Isemura

Keyword(s):

Surface Chemistry ◽

Glutamic Acid ◽

Synthetic Protein

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Controlled release of macromolecules and pharmaceuticals from synthetic polypeptides based on glutamic acid

Biopolymers ◽

10.1002/bip.360220167 ◽

1983 ◽

Vol 22 (1) ◽

pp. 547-556 ◽

Cited By ~ 23

Author(s):

Kenneth R. Sidman ◽

William D. Steber ◽

Arthur D. Schwope ◽

Gayle R. Schnaper

Keyword(s):

Controlled Release ◽

Glutamic Acid ◽

Synthetic Polypeptides

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Catalytic actions of synthetic polypeptides: 1. Decomposition of hydrogen peroxide by the poly(l-glutamic acid) — copper(II) complex

International Journal of Biological Macromolecules ◽

10.1016/0141-8130(80)90086-0 ◽

1980 ◽

Vol 2 (4) ◽

pp. 263-265 ◽

Cited By ~ 3

Author(s):

Hiroyuki Yamamoto ◽

Katsuhiko Inouye ◽

Tadao Hayakawa

Keyword(s):

Hydrogen Peroxide ◽

Glutamic Acid ◽

Synthetic Polypeptides

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Genetic control of major histocompatibility complex-linked immune responses to synthetic polypeptides in man: poly(L-phenylalanine, L-glutamic acid)-poly (DL-alanine)--poly(L-lysine) and L-glutamic acid, L-alanine, L-tyrosine (60:30:10).

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.81.11.3521 ◽

1984 ◽

Vol 81 (11) ◽

pp. 3521-3525

Author(s):

M. M. Chan ◽

W. B. Bias ◽

S. H. Hsu ◽

D. A. Meyers

Keyword(s):

Major Histocompatibility Complex ◽

Immune Responses ◽

Glutamic Acid ◽

Genetic Control ◽

Major Histocompatibility ◽

Histocompatibility Complex ◽

Synthetic Polypeptides

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Surface Chemistry of Synthetic Protein Analogues. VI. The Interaction of Urea and Salt with Non-electrolytic Polypeptides

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.28.185 ◽

1955 ◽

Vol 28 (3) ◽

pp. 185-189 ◽

Cited By ~ 8

Author(s):

Toshizo Isemura ◽

Kozo Hamaguchi ◽

Hideyo Kawasato

Keyword(s):

Surface Chemistry ◽

Synthetic Protein

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Surface Chemistry of Synthetic Protein Analogues. II. Temperature Dependence of the Force-Area Relations of Some Polypeptides Monolayers and Thickness of the Monolayer

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.26.425 ◽

1953 ◽

Vol 26 (8) ◽

pp. 425-429 ◽

Cited By ~ 19

Author(s):

Toshizo Isemura ◽

Kozo Hamaguchi

Keyword(s):

Surface Chemistry ◽

Temperature Dependence ◽

Synthetic Protein

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Degradation of Synthetic Polypeptides. II. Degradation of Poly-α,L-glutamic Acid by Proteolytic Enzymes in 0.20MSodium Chloride

Journal of the American Chemical Society ◽

10.1021/ja01073a001 ◽

1964 ◽

Vol 86 (19) ◽

pp. 3913-3918 ◽

Cited By ~ 23

Author(s):

Wilmer G. Miller

Keyword(s):

Glutamic Acid ◽

Proteolytic Enzymes ◽

Synthetic Polypeptides

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N-Heterocyclic Carbene-Catalyzed Random Copolymerization of N-Carboxyanhydrides of α-Amino Acids

Polymers ◽

10.3390/polym13213674 ◽

2021 ◽

Vol 13 (21) ◽

pp. 3674

Author(s):

Kuen Hee Eom ◽

Seokhyeon Baek ◽

Il Kim

Keyword(s):

Amino Acids ◽

Glutamic Acid ◽

Primary Structure ◽

Reactivity Ratio ◽

Synthetic Polypeptides ◽

Random Placement ◽

Natural Peptides ◽

The Relationship ◽

Method Show

Synthetic polypeptides prepared from N-carboxyanhydrides (NCAs) of α-amino acids are useful for elucidating the relationship between the primary structure of natural peptides and their immunogenicity. In this study, complex copolypeptide sequences were prepared using a recently developed technique; specifically, the random copolymerization of l-alanine NCA with NCAs of l-glutamic acid 5-benzylester (Bn-Glu NCA), S-benzyl-cysteine (Bn-Cys NCA), O-benzyl-l-serine (Bn-Ser NCA), and l-phenylalanine (Phe NCA) was performed using N-heterocyclic carbene (NHC) catalysts. The NHC-initiated Ala NCA/Bn-Glu NCA and Ala NCA/Bn-Cys NCA copolymerization reactions achieved 90% conversion within 30 min. The reactivity ratio values estimated using the Kelen and Tüdos method show that poly(Bn-Glu-co-Ala) and poly(Bn-Cys-co-Ala) have random repeating units with rich alternating sequences, whereas poly(Bn-Ser-co-Ala) and poly(Phe-co-Ala) contain a larger proportion of Ala-repeating units than Bn-Ser and Phe in random placement.

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