Surface-Assisted Laser Desorption Ionization Mass Spectrometry (SALDI-MS) of Low-Molecular-Weight Medicines and Toxic Materials Using Commercial TiO2 Nanoparticles

2016 ◽  
Vol 89 (3) ◽  
pp. 346-353 ◽  
Author(s):  
Tetsu Yonezawa ◽  
Takashi Asano ◽  
Masaki Matsubara
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Laser Desorption ◽  
Low Molecular Weight ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Toxic Materials ◽  
Commercial Tio2 ◽  
Saldi Ms

scholarly journals Effects of Carbon Nanowalls (CNWs) Substrates on Soft Ionization of Low-Molecular-Weight Organic Compounds in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS)

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 262
Author(s):  
Ryusei Sakai ◽  
Tomonori Ichikawa ◽  
Hiroki Kondo ◽  
Kenji Ishikawa ◽  
Naohiro Shimizu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Laser Desorption ◽  
Low Molecular Weight ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Wall Distance ◽  
Desorption Ionization ◽  
Carbon Nanowalls ◽  
Saldi Ms

Carbon nanowalls (CNWs), which are vertically oriented multi-layer graphene sheets, were employed in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) measurements to detect low-molecular-weight organic compounds. CNWs substrates with widely different wall-to-wall distances from 142 to 467 nm were synthesized using a radical-injection plasma-enhanced chemical vapor deposition (RI-PECVD) system with nanosecond pulse biasing to a sample stage. When survival yield (SY) values of N-benzylpyridinium chloride (N-BP-Cl) were examined, which is commonly used to evaluate desorption/ionization efficiency, a narrower wall-to-wall distance presented a higher SY value. The highest SY value of 0.97 was realized at 4 mJ/cm2 for the highest-density CNWs with a wall-to-wall distance of 142 nm. The laser desorption/ionization effect of arginine, an amino acid, was also investigated. When CNWs with a narrower wall-to-wall distance were used, the signal-to-noise (SN) ratios of the arginine signals were increased, while the intensity ratios of fragment ions to arginine signals were suppressed. Therefore, the CNWs nanostructures are a powerful tool when used as a SALDI substrate for the highly efficient desorption/ionization of low-molecular-weight biomolecules.

A novel trityl/acridine derivatization agent for analysis of thiols by (matrix-assisted)(nanowire-assisted)laser desorption/ionization and electrospray ionization mass spectrometry

2017 ◽  
Vol 9 (45) ◽  
pp. 6335-6340 ◽  
Author(s):  
Artyom P. Topolyan ◽  
Maria A. Belyaeva ◽  
Mariya S. Slyundina ◽  
Valentina V. Ilyushenkova ◽  
Andrey A. Formanovsky ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Laser Desorption ◽  
Fixed Charge ◽  
Low Molecular Weight ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization

A new agent was used for fixed-charge derivatization of low molecular weight thiols.

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