Synthesis of Water-Soluble Cyclophane Pentamers Using Click Chemistry as a Multivalent Host for Daunorubicin and Doxorubicin

2013 ◽  
Vol 86 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Osamu Hayashida ◽  
Yuki Nakamura
Keyword(s):  
Click Chemistry ◽  
Water Soluble

Methodology for functionalization of water oxidation catalyst IrOx nanoparticles with hydrophobic and multi-functionalized chromophores

2021 ◽  
Author(s):  
Liniquer A. Fontana ◽  
Vitor H. Rigolin ◽  
Carolyne B. Braga ◽  
Catia Ornelas ◽  
Jackson D. Megiatto
Keyword(s):  
Click Chemistry ◽  
Water Oxidation ◽  
Iridium Oxide ◽  
Water Soluble ◽  
Oxidation Catalyst ◽  
Oxide Nanoparticles

A straightforward “click” chemistry methodology for the sensitization of water soluble iridium oxide nanoparticles with hydrophobic and multi-functionalized porphyrin-based chromophores is described.

One-pot synthesis of bio-functionally water-soluble POSS derivatives via efficient click chemistry methodology

2019 ◽  
Vol 140 ◽  
pp. 103-110 ◽  
Author(s):  
Jifeng Zhang ◽  
Zhanpeng Luo ◽  
Wanjie Wang ◽  
Yanyu Yang ◽  
Dawei Li ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Water Soluble ◽  
One Pot ◽  
One Pot Synthesis

Bioconjugatable synthetic chlorins rendered water-soluble with three PEG-12 groups via click chemistry

2020 ◽  
Vol 24 (01n03) ◽  
pp. 362-378 ◽  
Author(s):  
Nobuyuki Matsumoto ◽  
Masahiko Taniguchi ◽  
Jonathan S. Lindsey
Keyword(s):  
Aqueous Solution ◽  
Quantum Yield ◽  
Click Chemistry ◽  
Fluorescence Quantum Yield ◽  
Molecular Design ◽  
Water Soluble ◽  
Propanoic Acid ◽  
Free Base ◽  
Yield Formula ◽  
Water Solubilization

Chlorins provide many ideal features for use as red-region fluorophores but require molecular tailoring for solubilization in aqueous solution. A chlorin building-block bearing 18,18-dimethyl, 15-bromo and 10-[2,4,6-tris(propargyloxy)phenyl] substituents has been transformed via click chemistry with CH3(OCH2CH[Formula: see text]-N3 followed by Suzuki coupling with 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid, thereby installing a water-solubilization motif and a bioconjugatable handle, respectively. In toluene, [Formula: see text]-dimethylformamide (DMF) or water, the resulting facially encumbered free base chlorin exhibits characteristic chlorin absorption ([Formula: see text] [Formula: see text]412, 643 nm) and fluorescence ([Formula: see text] [Formula: see text]645 nm) spectra with only modest variation in fluorescence quantum yield ([Formula: see text] values (0.24, 0.25 and 0.19, respectively). The zinc chlorin derived therefrom exhibits similar spectral constancy ([Formula: see text] [Formula: see text]414 and 613 nm, [Formula: see text] [Formula: see text]616 nm) and [Formula: see text] 0.094, 0.10 and 0.086 in the three solvents. The results together indicate the viability of the molecular design and synthetic methodology to create red-region fluorophores for use in diverse applications.

scholarly journals Synthesis of Water-Soluble Camptothecin–Polyoxetane Conjugates via Click Chemistry

2012 ◽  
Vol 9 (11) ◽  
pp. 3403-3408 ◽  
Author(s):  
Olga Yu. Zolotarskaya ◽  
Alison F. Wagner ◽  
Jason M. Beckta ◽  
Kristoffer Valerie ◽  
Kenneth J. Wynne ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Water Soluble

Synthesis of pH-sensitive, water-soluble paclitaxel prodrugs based on norbornene-functional polylactide by copper-free click chemistry

2016 ◽  
Vol 65 (15) ◽  
pp. 789-796 ◽  
Author(s):  
Ji Wang ◽  
Huicong Zhou ◽  
Qixuan Zheng ◽  
Jing Yan ◽  
Pei Liu ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Ph Sensitive ◽  
Water Soluble

Efficient Synthesis of Water-Soluble Calixarenes Using Click Chemistry

2005 ◽  
Vol 7 (6) ◽  
pp. 1035-1037 ◽  
Author(s):  
Eui-Hyun Ryu ◽  
Yan Zhao
Keyword(s):  
Click Chemistry ◽  
Water Soluble ◽  
Efficient Synthesis
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