Construction of the ABC Ring System of Taxanes via Stereoselective One-Pot Three-Component Coupling and Intramolecular Alkylation of a Protected Cyanohydrin Ether

2010 ◽  
Vol 83 (8) ◽  
pp. 942-949 ◽  
Author(s):  
Takayuki Serizawa ◽  
Shigeru Miyamoto ◽  
Shinichiro Fuse ◽  
Takayuki Doi ◽  
Takashi Takahashi
Keyword(s):  
Ring System ◽  
One Pot ◽  
Intramolecular Alkylation ◽  
Three Component Coupling

ChemInform Abstract: Construction of the ABC Ring System of Taxanes via Stereoselective One-Pot Three-Component Coupling and Intramolecular Alkylation of a Protected Cyanohydrin Ether.

ChemInform ◽  
2010 ◽  
Vol 41 (50) ◽  
pp. no-no
Author(s):  
Takayuki Serizawa ◽  
Shigeru Miyamoto ◽  
Shinichiro Fuse ◽  
Takayuki Doi ◽  
Takashi Takahashi
Keyword(s):  
Ring System ◽  
One Pot ◽  
Intramolecular Alkylation ◽  
Three Component Coupling

Stereoselective one-pot three-component coupling approach towards the synthesis of the AC ring system of taxanes

2009 ◽  
Vol 50 (26) ◽  
pp. 3408-3410 ◽  
Author(s):  
Takayuki Serizawa ◽  
Shigeru Miyamoto ◽  
Yoshitaka Numajiri ◽  
Shinichiro Fuse ◽  
Takayuki Doi ◽  
...  
Keyword(s):  
Ring System ◽  
One Pot ◽  
Coupling Approach ◽  
Ac Ring ◽  
Three Component Coupling

scholarly journals One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes

2010 ◽  
Vol 6 ◽  
Author(s):  
Priyabrata Roy ◽  
Binay Krishna Ghorai
Keyword(s):  
Diels Alder ◽  
Fischer Carbene Complexes ◽  
One Pot ◽  
Carbene Complexes ◽  
Ring Systems ◽  
First Report ◽  
Fischer Carbene ◽  
Carbonyl Derivatives ◽  
Transient Intermediates ◽  
Three Component Coupling

One-pot three-component coupling ofo-alkynylheteroaryl carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of quinoxaline and phenazine ring systems has been investigated. This involves the generation of furo[3,4-b]pyrazine and furo[3,4-b]quinoxaline as transient intermediates, which were trapped with Diels–Alder dienophiles. This is the first report on furo[3,4-b]pyrazine intermediates.

Stereoselective One-Pot Method for the Introduction of an Amino Group to a Cyclohexane Ring. Preparation of the Octahydroisobenzofuro[7a,1-d]oxazole Ring System

Synthesis ◽  
1992 ◽  
Vol 1992 (12) ◽  
pp. 1261-1264 ◽  
Author(s):  
Kenji Saito ◽  
Hideo Takagi ◽  
Makoto Yamamoto ◽  
Kazutoshi Yamada
Keyword(s):  
Ring System ◽  
Cyclohexane Ring ◽  
Amino Group ◽  
One Pot ◽  
Oxazole Ring

An Efficient and Convenient Approach to the Synthesis of Benzopyrans by a Three-Component Coupling of One-Pot Reaction

Synlett ◽  
2003 ◽  
pp. 2001-2004 ◽  
Author(s):  
Tong-Shou Jin ◽  
Jin-Chong Xiao ◽  
Su-Juan Wang ◽  
Tong-Shuang Li ◽  
Xin-Ru Song
Keyword(s):  
One Pot ◽  
Convenient Approach ◽  
Three Component Coupling

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1493-1498 ◽  
Author(s):  
Shinichiro Fuse ◽  
Hiroyuki Nakamura ◽  
Megumi Inaba ◽  
Shinichi Sato ◽  
Manjusha Joshi
Keyword(s):  
Drug Discovery ◽  
Rapid Development ◽  
Ring System ◽  
Biologically Active ◽  
Drug Candidate ◽  
One Pot ◽  
Ring Systems ◽  
Drug Candidates ◽  
Fused Ring ◽  
Snar Reaction

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot SNAr reaction/intramolecular C–H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

Very mild and efficient one-pot access to the valuable 2-hydroxybicyclo[3.2.1]octan-8-one ring system

1993 ◽  
pp. 571 ◽  
Author(s):  
Nicole Ouvrard ◽  
Philippe Ouvrard ◽  
Jean Rodriguez ◽  
Maurice Santelli
Keyword(s):  
Ring System ◽  
One Pot
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