Intravital imaging reveals cell cycle-dependent satellite cell migration during muscle regeneration

2020 ◽  
Author(s):  
Louise Moyle
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Satellite Cell ◽  
Muscle Regeneration ◽  
Intravital Imaging ◽  
Cycle Dependent

scholarly journals Intravital imaging reveals cell cycle-dependent myogenic cell migration during muscle regeneration

Cell Cycle ◽  
2020 ◽  
Vol 19 (22) ◽  
pp. 3167-3181
Author(s):  
Yumi Konagaya ◽  
Kanako Takakura ◽  
Maina Sogabe ◽  
Anjali Bisaria ◽  
Chad Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Muscle Regeneration ◽  
Intravital Imaging ◽  
Myogenic Cell ◽  
Cycle Dependent

scholarly journals Intravital imaging reveals cell cycle-dependent satellite cell migration during muscle regeneration

2020 ◽  
Author(s):  
Yumi Konagaya ◽  
Kanako Takakura ◽  
Maina Sogabe ◽  
Anjali Bisaria ◽  
Chad Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Muscle Regeneration ◽  
Intravital Imaging ◽  
Migration Speed ◽  
And Migration ◽  
Erk Activity ◽  
Proliferation And Migration

AbstractDuring muscle regeneration, extracellular signal-regulated kinase (ERK) promotes both proliferation and migration. However, the relationship between proliferation and migration is poorly understood in this context. To elucidate this complex relationship on a physiological level, we established an intravital imaging system for measuring ERK activity, migration speed, and cell-cycle phases in mouse muscle satellite cells. We found that in vivo, ERK was maximally activated in satellite cells two days after injury, and this is then followed by increases in cell number and motility. With limited effects of immediate ERK activity on migration, we hypothesized that ERK increases migration speed in the later phase by promoting cell-cycle progression. Our cell-cycle analysis further revealed that in satellite cells, ERK activity is critical for the G1/S transition, and cells migrate more rapidly in the S/G2 phase three days after injury. Finally, migration speed of satellite cells was suppressed after CDK1/2, but not CDK1, inhibitor treatment, demonstrating a critical role of CDK2 in satellite cell migration. Overall, our study demonstrates that in satellite cells, the ERK-CDK2 axis not only promotes the G1/S transition, but also migration speed, which may provide a novel mechanism for efficient muscle regeneration.

scholarly journals Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration

2017 ◽  
Vol 5 (19) ◽  
pp. e13394
Author(s):  
Akos Varga ◽  
Jothi Dinesh Kumar ◽  
Alec W.M. Simpson ◽  
Steven Dodd ◽  
Peter Hegyi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Putative Role ◽  
Cycle Dependent ◽  
Cck2 Receptor

Volume-activated chloride channels contribute to cell-cycle-dependent regulation of HeLa cell migration

2009 ◽  
Vol 77 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Jianwen Mao ◽  
Lixin Chen ◽  
Bin Xu ◽  
Lijing Wang ◽  
Weizhang Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Hela Cell ◽  
Chloride Channels ◽  
Cycle Dependent

scholarly journals Abstract 1876: Cell cycle-dependent front polarized cell migration requires Aurora kinase A

2017 ◽  
Author(s):  
Tony Lok Heng Chu ◽  
Lixin Zhou ◽  
Jennifer Won ◽  
Pooja Mohan ◽  
Oksana Nemirovsky ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Aurora Kinase ◽  
Aurora Kinase A ◽  
Cycle Dependent ◽  
Kinase A

Cell cycle dependent modulation of insulin and IGF I receptor binding to human Burkitt type ALL cells

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S81
Author(s):  
U. VETTER ◽  
W. HARTMANN ◽  
H. HITZLER ◽  
W. HEIT ◽  
J. SCHLICKENRIEDER ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Receptor Binding ◽  
Igf I ◽  
Cycle Dependent
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