Variant antigen diversity in Trypanosoma vivax is not driven by recombination

2019 ◽  
Author(s):  
Mariana De Niz
Keyword(s):  
Trypanosoma Vivax ◽  
Variant Antigen

scholarly journals Variant antigen diversity in Trypanosoma vivax is not driven by recombination

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Sara Silva Pereira ◽  
Kayo J. G. de Almeida Castilho Neto ◽  
Craig W. Duffy ◽  
Peter Richards ◽  
Harry Noyes ◽  
...  
Keyword(s):  
Trypanosoma Vivax ◽  
Variant Antigen

Molecular epidemiological insights into Trypanosoma vivax in Argentina: from the endemic Gran Chaco to outbreaks in the Pampas

2021 ◽  
Author(s):  
Andrea S. Florentin ◽  
Herakles A. Garcia P ◽  
Carla M.F. Rodrigues ◽  
Eugenio F. Dubois ◽  
Carlos M. Monzón ◽  
...  
Keyword(s):  
Trypanosoma Vivax ◽  
Gran Chaco

Different kinetoplast degradation patterns in American Trypanosoma vivax strains: Multiple independent origins or fast evolution?

Genomics ◽  
2021 ◽  
Author(s):  
Gonzalo Greif ◽  
Matias Rodriguez ◽  
Ivan Bontempi ◽  
Carlos Robello ◽  
Fernando Alvarez-Valin
Keyword(s):  
Trypanosoma Vivax ◽  
Fast Evolution

Parasite-specific antibody reponses of responses of ruminants infected withTrypanosoma vivax

Parasitology ◽  
1990 ◽  
Vol 100 (1) ◽  
pp. 93-100 ◽  
Author(s):  
G. J. Vos ◽  
P. R. Gardiner
Keyword(s):  
Specific Antibody ◽  
Similar Pattern ◽  
Protein Band ◽  
Lytic Activity ◽  
Antibody Activity ◽  
Polyacrylamide Gels ◽  
Trypanosoma Vivax ◽  
Variable Surface ◽  
Immune Assays ◽  
Antigenic Type

SummarySera from goats and cattle that were infected with twoTrypanosoma vivaxclones (ILDat 1.2 and ILDat 2.1) derived from different stocks were analysed for antibody activity against the variable surface glycoproteins (VSGs) of the infecting clones by enzyme-linked immune assays (ELISA) and immune lysis. To obtain purified VSG, lysed trypanosomes were separated on dodecyl sulphate-polyacrylamide gels. The gels were copper stained and the VSG protein band was excised from the gel. After destaining, the proteins were electroeluted from the gel slices and used as antigens in ELISA. High titres of IgM and IgG1antibodies and lytic antibodies against the VSG of the infecting clone were detected. The IgG1response appeared about 4 days later than the IgM response. IgG2antibodies were only detected in goats and cattle that were infected with ILDat 1.2. Two goats and two calves that were infected with ILDat 1.2 showed recurrent peaks in lytic activity and of IgM and IgG1antibody activity to the VSG of the infecting variable antigenic type (VAT). Two goats that were infected with ILDat 2.1 showed a similar pattern, but in two other goats there was a recurrent peak only in the IgM class. Recurrent peaks of antibody activity to the VSG of ILDat 1.2 and ILDat 2.1 were not detected in the sera of goats that had been inoculated with irradiated trypanosomes or that had been infected with an unrelatedT. vivaxclone. The recurrence of antibody peaks against the VSG of infecting VATs suggests that trypanosomes with completely or partially identical surface determinants reappear duringT. vivaxinfection of ruminants.

Sign in / Sign up

Export Citation Format

Share Document