scholarly journals The Effects of High and Low Temperatures on the Epidermal Mitotic Activity of the Adult Male Mouse, Mus Musculus L

1949 ◽  
Vol 26 (1) ◽  
pp. 76-82
Author(s):  
W. S. BULLOUGH
Keyword(s):  
Mitotic Activity ◽  
Adult Male ◽  
Mus Musculus ◽  
Low Temperatures ◽  
Male Mouse ◽  
Adult Male Mouse ◽  
High And Low Temperatures

scholarly journals The effects of experimentally induced rest and exercise on the epidermal mitotic activity of the adult male mouse, Mus musculus L

1948 ◽  
Vol 135 (879) ◽  
pp. 233-242 ◽  
Keyword(s):  
Mitotic Activity ◽  
Adult Male ◽  
Male Mouse ◽  
Time Of Day ◽  
Excessive Exercise ◽  
Adult Male Mouse ◽  
Preliminary Study ◽  
High Level ◽  
Mitosis Rate ◽  
Rest And Exercise

As a preliminary study of the conditions which affect the hour to hour variations in epidermal mitotic activity in the adult male mouse, experiments were carried out involving artificially induced sleep and exercise. In the first experiment the animals were injected with a dose of barbiturates sufficient to induce sleep for a period of 3 or 4 hr. at a time of day when they were usually active. The injections were given at 17.00 hr. as the animals were waking from their afternoon sleep, and they resulted in a sharp rise in mitotic activity. A maximum was reached at 20.00 hr., the time when the mitotic activity of the controls had dropped to a minimum. As the animals recovered and became active, their mitosis rate fell quickly to a low level. In the second experiment the animals were placed in a slowly revolving box, and so forced to remain awake and active throughout an afternoon when they would otherwise have been asleep. This treatment resulted in extremely low mitotic activity, in contrast to which that of the normally sleeping controls rose to a high level. It is probably significant that when the mice were released from the revolving box, and could at last sleep, their mitosis rate remained low. This suggests that the excessive exercise had either resulted in the production of some mitosis-depressing substance which remained in the system, or that some substance vital to mitosis had been used up and took some time to be replaced. The conclusion is now justified that the rate of epidermal mitosis normally increases during sleep, and decreases during hours of wakefulness and exercise. In this way the form of the diurnal mitosis cycle is determined by the habits of the animals.

scholarly journals Mitotic activity in the adult male mouse, Mus musculus L. The diurnal cycles and their relation to waking and sleeping

1948 ◽  
Vol 135 (879) ◽  
pp. 212-233 ◽  
Keyword(s):  
Cell Division ◽  
Mitotic Activity ◽  
Adult Male ◽  
Individual Variation ◽  
Male Mouse ◽  
Duodenal Mucosa ◽  
Seminiferous Tubules ◽  
Diurnal Cycles ◽  
Adult Male Mouse ◽  
Bodily Activity

The diurnal cycles of mitotic activity in the ear epidermis of the adult male mouse have been determined by the removal of earclips at 2 hr. intervals throughout the 24 hr. The mice used were between 3 and 4 months old, and were of the Kreyberg white label and Strong’s CBA strains. A considerable degree of individual variation was found, but on the average the maximum mitotic activity was at 06.00 and 14.00 hr. and the minimum mitotic activity at 10.00 and 20.00 hr. This observation was confirmed by killing groups of mice, each group consisting of five males, at the same 2 hr. intervals throughout the 24 hr. Similar variations in the mitotic activity of the ear epidermis were observed, and, in addition, similar cycles were evident in the mid-dorsal epidermis of the back, the stratified epithelium of the oesophagus, the lining epithelium of the epididymis, and the proliferating zone of the duodenal mucosa. In this last tissue the rate of cell division never fell to a very low figure, and in the proliferating centres of the intestinal lymph nodules and in the seminiferous tubules of the testis there was no trace of a cycle since the rate of cell division remained constantly high. A study was also made of the spontaneous bodily activity of the mice throughout the 24 hr., and by comparing the average figures so obtained with the average figures for epidermal mitosis, it proved possible to make the significant correlation that when the animals are at rest mitotic activity is at a maximum and that when they are awake and active it is at a minimum. This correlation permits an explanation of the individual variation in mitotic activity, since there is also a high degree of individual variation in spontaneous bodily activity. It also permits an explanation of the contradictory results which have been reported in the past regarding diurnal mitosis rhythms in mice, since it is evident that the rhythms of bodily activity must be strongly affected by differences in the age, sex and condition of the animals used, in the season of the year, and in the routine of the laboratory.

The Relation Between the Epidermal Mitotic Activity and the Blood-Sugar Level in the Adult Male Mouse, Mus Musculus L

1949 ◽  
Vol 26 (1) ◽  
pp. 83-99
Author(s):  
W. S. BULLOUGH
Keyword(s):  
Mitotic Activity ◽  
Blood Sugar ◽  
Adult Male ◽  
Male Mouse ◽  
Blood Sugar Level ◽  
Normal Animal ◽  
Critical Factor ◽  
Diurnal Changes ◽  
Adult Male Mouse ◽  
Mitosis Rate

1. An investigation has been made of the relation between the concentration of the blood sugar and the mitotic activity of the ear epidermis of the adult male mouse. It has been shown that, within limits, an increase in the blood-sugar level, induced by subcutaneous injections of starch, results in an increased mitosis rate. Conversely, a decrease in the blood-sugar level, induced by insulin, causes a decreased mitosis rate. A deep mitosis depression is also caused by injections of phloridzin. 2. Since it is known that phloridzin interferes with the phosphorylation of sugar, and since it is also shown that injections of phosphate augment the effect produced by starch alone, the tentative suggestion is put forward that sugar may act by satisfying the energy requirements of mitosis. 3. However, in the normal animal the diurnal changes in the blood-sugar level are the inverse of the diurnal changes in mitotic activity, the concentration of the blood sugar being relatively low during sleep when the mitosis rate is relatively high. It is therefore evident that, within normal limits, the level of the blood sugar as such is not an important factor in the control of the diurnal mitosis cycles. 4. It is considered probable that the critical factor in the control of these cycles is the concentration of sugar, or glycogen, within the tissues themselves. Thus during sleep, sugar is probably deposited in the tissues, as it is known to be in the liver, so accounting simultaneously for the fall in the level of the blood sugar and the rise in the mitosis rate.

scholarly journals Transurethral Instillation Procedure in Adult Male Mouse

10.3791/56663 ◽  
2017 ◽  
Author(s):  
Sanghee Lee ◽  
Alonso Carrasco ◽  
Randall B. Meacham ◽  
Anna P. Malykhina
Keyword(s):  
Adult Male ◽  
Male Mouse ◽  
Adult Male Mouse

Role of the Non-Canonical Notch Ligand Delta-Like Protein 1 in Hormone-Producing Cells of the Adult Male Mouse Pituitary

2011 ◽  
Vol 23 (9) ◽  
pp. 849-859 ◽  
Author(s):  
R. A. Puertas-Avendaño ◽  
M. J. González-Gómez ◽  
M. D. Ruvira ◽  
M. J. Ruiz-Hidalgo ◽  
N. Morales-Delgado ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Mouse ◽  
Notch Ligand ◽  
Adult Male Mouse ◽  
Mouse Pituitary

scholarly journals Kcne2 Expression is Regulated both by Estrogen and Cardiac Stress in the Adult Male Mouse Heart

2010 ◽  
Vol 98 (3) ◽  
pp. 136a
Author(s):  
Jingyuan Li ◽  
Andrea Ciobotaru ◽  
Soban Umar ◽  
Shuxun Ren ◽  
Mansoureh Eghbali
Keyword(s):  
Adult Male ◽  
Male Mouse ◽  
Mouse Heart ◽  
Cardiac Stress ◽  
Adult Male Mouse
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