scholarly journals Malpighian tubules of caterpillars: blending RNAseq and physiology to reveal regional functional diversity and novel epithelial ion transport control mechanisms

2019 ◽  
Vol 222 (22) ◽  
pp. jeb211623 ◽  
Author(s):  
Dennis Kolosov ◽  
Michael J. O'Donnell
Keyword(s):  
Ion Transport ◽  
Functional Diversity ◽  
Malpighian Tubules ◽  
Control Mechanisms ◽  
Epithelial Ion Transport ◽  
Transport Control

scholarly journals Resolvin D1 regulates epithelial ion transport and inflammation in cystic fibrosis airways

2018 ◽  
Vol 17 (5) ◽  
pp. 607-615 ◽  
Author(s):  
Fiona C. Ringholz ◽  
Gerard Higgins ◽  
Aurélie Hatton ◽  
Ali Sassi ◽  
Ahmad Moukachar ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Ion Transport ◽  
Resolvin D1 ◽  
Epithelial Ion Transport

Effect of E-Cigarettes on Airway Epithelial Ion Transport and Implications for Mucociliary Clearance Defense

CHEST Journal ◽  
2015 ◽  
Vol 148 (4) ◽  
pp. 618A ◽  
Author(s):  
Matthew Fain ◽  
Vamsee Raju ◽  
Vivian Lin ◽  
Li Ping Tang ◽  
Courtney Fernandez ◽  
...  
Keyword(s):  
Ion Transport ◽  
Mucociliary Clearance ◽  
Airway Epithelial ◽  
Epithelial Ion Transport

The anterior and posterior ‘stomach’ regions of larval Aedes aegypti midgut: regional specialization of ion transport and stimulation by 5-hydroxytryptamine

1999 ◽  
Vol 202 (3) ◽  
pp. 247-252 ◽  
Author(s):  
T.M. Clark ◽  
A. Koch ◽  
D.F. Moffett
Keyword(s):  
Steady State ◽  
Aedes Aegypti ◽  
Ion Transport ◽  
Malpighian Tubules ◽  
Transport Mechanisms ◽  
Regional Specialization ◽  
Negative Deflection ◽  
Electrical Polarity

The ‘stomach’ region of the larval mosquito midgut is divided into histologically distinct anterior and posterior regions. Anterior stomach perfused symmetrically with saline in vitro had an initial transepithelial potential (TEP) of −66 mV (lumen negative) that decayed within 10–15 min to a steady-state TEP near −10 mV that was maintained for at least 1 h. Lumen-positive TEPs were never observed in the anterior stomach. The initial TEP of the perfused posterior stomach was opposite in polarity, but similar in magnitude, to that of the anterior stomach, measuring +75 mV (lumen positive). This initial TEP of the posterior stomach decayed rapidly at first, then more slowly, eventually reversing the electrical polarity of the epithelium as lumen-negative TEPs were recorded in all preparations within 70 min. Nanomolar concentrations of the biogenic amine 5-hydroxytryptamine (5-HT, serotonin) stimulated both regions, causing a negative deflection of the TEP of the anterior stomach and a positive deflection of the TEP of the posterior stomach. Phorbol 12,13-diacetate also caused a negative deflection of the TEP of the anterior stomach, but had no effect on the TEP of the posterior stomach. These data demonstrate that 5-HT stimulates region-specific ion-transport mechanisms in the stomach of Aedes aegypti and suggest that 5-HT coordinates the actions of the Malpighian tubules and midgut in the maintenance of an appropriate hemolymph composition in vivo.

Membrane dynamics in insect malpighian tubules

1989 ◽  
Vol 257 (5) ◽  
pp. R967-R972
Author(s):  
T. J. Bradley
Keyword(s):  
Ion Transport ◽  
Driving Force ◽  
Fluid Secretion ◽  
Membrane Dynamics ◽  
Malpighian Tubules ◽  
Membrane Insertion ◽  
Cation Pump ◽  
Active Ion Transport ◽  
Urine Formation ◽  
Apical Membranes

Urine formation in insects occurs in the Malpighian tubules by means of active ion transport and osmotically coupled water flow. The rates of urine formation can vary with time and can be modulated by diuretic hormones, developmental events, and intracellular parasitism. This paper reviews a number of recent studies in which it has been demonstrated that variations in transport rate are associated with substantial changes in tubule ultrastructure in the form of membrane insertion into and deletion from the apical microvilli. The principal driving force for fluid movement in Malpighian tubules is thought to be a common cation pump located in the apical membranes. It is proposed that modulation of the apical microvillar membrane may reflect regulation by the cells of the number of common cation pump units involved in fluid secretion.

Mathematical Modeling of Epithelial Ion Transport

2020 ◽  
pp. 115-133
Author(s):  
David P. Nickerson ◽  
Leyla Noroozbabaee ◽  
Dewan M. Sarwar ◽  
Kirk L. Hamilton ◽  
Peter J. Hunter
Keyword(s):  
Mathematical Modeling ◽  
Ion Transport ◽  
Epithelial Ion Transport
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