scholarly journals Drosophila DNA/RNA methyltransferase contributes to robust host defense in aging animals by regulating sphingolipid metabolism

2018 ◽  
Vol 221 (22) ◽  
pp. jeb187989 ◽  
Author(s):  
Varada Abhyankar ◽  
Bhagyashree Kaduskar ◽  
Siddhesh S. Kamat ◽  
Deepti Deobagkar ◽  
Girish S. Ratnaparkhi
Keyword(s):  
Host Defense ◽  
Sphingolipid Metabolism

scholarly journals Drosophila DNA/RNA methyltransferase contributes to robust host defense in ageing animals by regulating sphingolipid metabolism

2018 ◽  
Author(s):  
Varada Abhyankar ◽  
Bhagyashree Kaduskar ◽  
Siddhesh S. Kamat ◽  
Deepti Deobagkar ◽  
Girish Ratnaparkhi
Keyword(s):  
Host Defense ◽  
Sphingolipid Metabolism ◽  
Storage Lipids ◽  
Age Dependent ◽  
Concomitant Reduction ◽  
Lyase Activity ◽  
Low Levels ◽  
S1p Lyase ◽  
Immune Defects ◽  
Lipid Imbalance

ABSTRACTDrosophila methyltransferase (Mt2) has been implicated in methylation of both DNA and tRNA. In this study, we demonstrate that loss of Mt2 activity leads to an age dependent decline of immune function in the adult fly. A newly eclosed adult has mild immune defects that exacerbate in a fifteen-day old Mt2−/− fly. The age dependent effects appear to be systemic, including disturbances in lipid metabolism, changes in cell shape of hemocytes and significant fold changes in levels of transcripts related to host defense. Lipid imbalance, as measured by quantitative lipidomics, correlates with immune dysfunction with high levels of immunomodulatory lipids, sphingosine-1phosphate (S1P) and ceramides, along with low levels of storage lipids. Activity assays on fly lysates confirm the age dependent increase in S1P and concomitant reduction of S1P lyase activity. We hypothesize that Mt2 functions to regulate genetic loci such as S1P lyase and this regulation is essential for robust host defense as the animal ages. Our study uncovers novel links between age dependent Mt2 function, innate immune response and lipid homeostasis.

Author response for "The NF‐κB transcription factor c‐Rel controls host defense against Citrobacter rodentium"

2019 ◽  
Author(s):  
Maik Luu ◽  
Rossana Romero ◽  
Jasmin Bazant ◽  
Elfadil Abass ◽  
Sabrina Hartmann ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Host Defense ◽  
Author Response ◽  
Citrobacter Rodentium ◽  
Factor C

Role of the macrophage-inducible C-type lectin Mincle in the lung host defense against mycobacterial infections in mice

Pneumologie ◽  
2011 ◽  
Vol 65 (12) ◽  
Author(s):  
F Behler ◽  
K Steinwede ◽  
R Maus ◽  
J Bohling ◽  
UA Maus
Keyword(s):  
Host Defense ◽  
Mycobacterial Infections
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