scholarly journals Potential trade-offs between biomineralization and immunity revealed by shell properties and gene expression profiles of two closely related Crassostrea species

2018 ◽  
Vol 221 (18) ◽  
pp. jeb183236 ◽  
Author(s):  
Anna V. Ivanina ◽  
Ballav M. Borah ◽  
Angela Vogts ◽  
Ifra Malik ◽  
Jingyao Wu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Trade Offs ◽  
Crassostrea Species

scholarly journals Tumor diversity and the trade-off between universal cancer tasks

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jean Hausser ◽  
Pablo Szekely ◽  
Noam Bar ◽  
Anat Zimmer ◽  
Hila Sheftel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Molecular Data ◽  
Treatment Groups ◽  
Trade Offs ◽  
Multiple Tasks ◽  
Passenger Mutations ◽  
Tumor Gene Expression ◽  
Tumor Gene

AbstractRecent advances have enabled powerful methods to sort tumors into prognosis and treatment groups. We are still missing, however, a general theoretical framework to understand the vast diversity of tumor gene expression and mutations. Here we present a framework based on multi-task evolution theory, using the fact that tumors need to perform multiple tasks that contribute to their fitness. We find that trade-offs between tasks constrain tumor gene-expression to a continuum bounded by a polyhedron whose vertices are gene-expression profiles, each specializing in one task. We find five universal cancer tasks across tissue-types: cell-division, biomass and energy, lipogenesis, immune-interaction and invasion and tissue-remodeling. Tumors that specialize in a task are sensitive to drugs that interfere with this task. Driver, but not passenger, mutations tune gene-expression towards specialization in specific tasks. This approach can integrate additional types of molecular data into a framework of tumor diversity grounded in evolutionary theory.

1327: Gene Expression Profiles in Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 349-350
Author(s):  
Gaelle Fromont ◽  
Michel Vidaud ◽  
Alain Latil ◽  
Guy Vallancien ◽  
Pierre Validire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benign Prostatic Hyperplasia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostatic Hyperplasia
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