scholarly journals Contribution of a natural polymorphism in protein kinase G modulates electroconvulsive seizure recovery inDrosophila melanogaster

2018 ◽  
Vol 221 (14) ◽  
pp. jeb179747 ◽  
Author(s):  
Stephanie P. Kelly ◽  
Monica G. Risley ◽  
Leonor E. Miranda ◽  
Ken Dawson-Scully
Keyword(s):  
Protein Kinase ◽  
Protein Kinase G ◽  
Natural Polymorphism ◽  
Electroconvulsive Seizure

Dynamical Basis of Allosteric Activation for the Plasmodium falciparum Protein Kinase G

2021 ◽  
Author(s):  
Jinfeng Huang ◽  
Jung Ah Byun ◽  
Bryan VanSchouwen ◽  
Philipp Henning ◽  
Friedrich W. Herberg ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Protein Kinase ◽  
Protein Kinase G ◽  
Allosteric Activation ◽  
Falciparum Protein

scholarly journals Dehydroepiandrosterone promotes pulmonary artery relaxation by NADPH oxidation-elicited subunit dimerization of protein kinase G 1α

2014 ◽  
Vol 306 (4) ◽  
pp. L383-L391 ◽  
Author(s):  
Dhara Patel ◽  
Sharath Kandhi ◽  
Melissa Kelly ◽  
Boon Hwa Neo ◽  
Michael S. Wolin
Keyword(s):  
Pulmonary Hypertension ◽  
Protein Kinase ◽  
Pulmonary Arteries ◽  
Activation Mechanism ◽  
Protein Kinase G ◽  
Beneficial Effects ◽  
Vasp Phosphorylation ◽  
Vasodilator Activity ◽  
Nadph Oxidation ◽  
Knockin Mouse

The activity of glucose-6-phosphate dehydrogenase (G6PD) controls a vascular smooth muscle relaxing mechanism promoted by the oxidation of cytosolic NADPH, which has been associated with activation of the 1α form of protein kinase G (PKG-1α) by a thiol oxidation-elicited subunit dimerization. This PKG-1α-activation mechanism appears to contribute to responses of isolated endothelium-removed bovine pulmonary arteries (BPA) elicited by peroxide, cytosolic NADPH oxidation resulting from G6PD inhibition, and hypoxia. Dehydroepiandrosterone (DHEA) is a steroid hormone with pulmonary vasodilator activity, which has beneficial effects in treating pulmonary hypertension. Because multiple mechanisms have been suggested for the vascular effects of DHEA and one of the known actions of DHEA is inhibiting G6PD, we investigated whether it promoted relaxation associated with NADPH oxidation, PKG-1α dimerization, and PKG activation detected by increased vasodilator-stimulated phosphoprotein (VASP) phosphorylation. Relaxation of BPA to DHEA under aerobic or hypoxic conditions was associated with NADPH oxidation, PKG-1α dimerization, and increased VASP phosphorylation. The vasodilator activity of DHEA was markedly attenuated in pulmonary arteries and aorta from a PKG knockin mouse containing a serine in place of a cysteine involved in PKG dimerization. DHEA promoted increased PKG dimerization in lungs from wild-type mice, which was not detected in the PKG knockin mouse model. Thus PKG-1α dimerization is a major contributing factor to the vasodilator actions of DHEA and perhaps its beneficial effects in treating pulmonary hypertension.

scholarly journals Protein Kinase G Phosphorylates Soluble Guanylyl Cyclase on Serine 64 and Inhibits Its Activity

2008 ◽  
Vol 28 (10) ◽  
pp. 1803-1810 ◽  
Author(s):  
Zongmin Zhou ◽  
Nazish Sayed ◽  
Anastasia Pyriochou ◽  
Charis Roussos ◽  
David Fulton ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Protein Kinase G
Sign in / Sign up

Export Citation Format

Share Document