scholarly journals Correction: Audiograms of three subterranean rodent species (genusFukomys) determined by auditory brainstem responses reveal extremely poor high-frequency cut-offs

2017 ◽  
Vol 220 (24) ◽  
pp. 4747-4747 ◽  
Author(s):  
Patricia Gerhardt ◽  
Yoshiyuki Henning ◽  
Sabine Begall ◽  
E. Pascal Malkemper
Keyword(s):  
High Frequency ◽  
Auditory Brainstem ◽  
Rodent Species ◽  
Auditory Brainstem Responses ◽  
Subterranean Rodent

Auditory Brainstem Responses in a Case of High-Frequency Conductive Hearing Loss

1985 ◽  
Vol 50 (4) ◽  
pp. 346-350 ◽  
Author(s):  
Michael P. Gorga ◽  
Jan K. Reiland ◽  
Kathryn A. Beauchaine
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Conductive Hearing Loss ◽  
Auditory Brainstem ◽  
Intensity Function ◽  
Auditory Brainstem Responses ◽  
Normal Limits ◽  
Interpeak Latency ◽  
Lower Limits ◽  
Conductive Hearing

Click-evoked auditory brainstem responses were measured in a patient with high-frequency conductive hearing loss. As is typical in cases of conductive hearing loss, Wave I latency was prolonged beyond normal limits. Interpeak latency differences were just below the lower limits of the normal range. The Wave V latency-intensity function, however was abnormally steep. This pattern is explained by the hypothesis that the slope of the latency-intensity function is determined principally by the configuration of the hearing loss. In cases of high-frequency hearing loss (regardless of the etiology), the response may be dominated by more apical regions of the cochlea at lower intensities and thus have a longer latency.

Comparison of ABR Stimuli for the Early Detection of Ototoxicity: Conventional Clicks Compared with High Frequency Clicks and Single Frequency Tonebursts

2003 ◽  
Vol 14 (05) ◽  
pp. 239-250 ◽  
Author(s):  
Stephen A. Fausti ◽  
Christopher L. Flick ◽  
Alison M. Bobal ◽  
Roger M. Ellingson ◽  
James A. Henry ◽  
...  
Keyword(s):  
Early Detection ◽  
High Frequency ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Single Frequency ◽  
Efficient Manner ◽  
High Frequencies ◽  
Objective Testing ◽  
Testing Methodology

Effective objective testing methodology is needed for early detection of the effects of ototoxicity on hearing in patients. The requirements for such testing include responses that are: 1) reliable across test sessions; 2) sensitive to ototoxic change (> 8 kHz), and 3) recordable in a time-efficient manner. Auditory brainstem responses (ABR) appear well suited to this task however, conventional clicks stimulate primarily mid-frequencies (1-4 kHz) and high frequency tonebursts require too much time. We hypothesized that delivery of a band of high frequencies (a high frequency "click"), would elicit reliable and useful ABRs. In the current study, flat and sloped HF (high frequency) clicks with a bandwidth of 8-14 kHz were used. The purpose was to compare brainstem responses elicited by tonebursts, two HF clicks and conventional clicks. The results show that the reliability of responses to the HF clicks were comparable to the tonebursts and further, both HF clicks produced responses slightly larger than tonebursts.

scholarly journals Hearing Ability of Prairie Voles (Microtus ochrogaster)

2021 ◽  
Author(s):  
Emily M New ◽  
Ben-Zheng Li ◽  
Tim Lei ◽  
Elizabeth A McCullagh
Keyword(s):  
High Frequency ◽  
Behavioral Responses ◽  
Binaural Hearing ◽  
Auditory Brainstem ◽  
Microtus Ochrogaster ◽  
Auditory Brainstem Responses ◽  
Biparental Care ◽  
Prairie Voles ◽  
Hearing Ability ◽  
Hearing Range

Hearing ability of mammals can be impacted by many factors including social cues, environment, and physical properties of animal morphology. Despite being used commonly to study social behaviors, the hearing ability of the monogamous prairie vole (Microtus ochrogaster) has never been fully characterized. In this study, we measure morphological head and pinna features and use auditory brainstem responses to measure hearing ability of prairie voles characterizing monaural and binaural hearing and hearing range. Additionally, we measured unbonded male and female voles to characterize differences due to sex. We found that prairie voles have intermediate hearing ability with an optimal hearing range of 8 to 32 kHz, robust binaural hearing ability, and characteristic monaural ABRs. We show no differences between the sexes for binaural hearing or hearing range, however female voles have increased amplitude of peripheral ABR waves I and II and increased latency of wave IV. Our results confirm that prairie voles have both low and high frequency hearing, binaural hearing capability, and despite biparental care and monogamy, differences in processing of sound information between the sexes. These data further highlight the necessity to understand sex-specific differences in neural processing that may underly variability in behavioral responses between sexes.

Reliability of Auditory Brainstem Responses from Sequenced High-Frequency (≥ 8 kHz) Tonebursts

1995 ◽  
Vol 34 (4) ◽  
pp. 177-188 ◽  
Author(s):  
Stephen A. Fausti ◽  
Curtin R. Mitchell ◽  
Richard H. Frey ◽  
James A. Henry ◽  
Jody L. O'Connor ◽  
...  
Keyword(s):  
High Frequency ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses

scholarly journals Applicability of subcortical EEG metrics of synaptopathy to older listeners with impaired audiograms

2018 ◽  
Author(s):  
Markus Garrett ◽  
Sarah Verhulst
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Sound Pressure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Individual Factors ◽  
Noise Floor ◽  
Age Related

AbstractEmerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known whether electrophysiological metrics targeting synaptopathy in animals can be applied to a broad range of people, such as those with impaired audiograms. This study investigates the applicability of subcortical electrophysiological measures associated with synaptopathy such as auditory brainstem responses (ABRs) and envelope following responses (EFRs) in older participants with high-frequency sloping audiograms. This is important for the development of reliable and sensitive synaptopathy diagnostics in people with normal or impaired outer-hair-cell function. Broadband click-ABRs at different sound pressure levels and EFRs to amplitude-modulated stimuli were recorded, as well as relative EFR and ABR metrics which reduce individual factors such as head size and noise floor level. Most tested metrics showed significant differences between the groups and did not always follow the trends expected from synaptopathy. Audiometric hearing loss and age-related hearing related deficits interacted to affect the electrophysiological metrics and complicated their interpretation in terms of synaptopathy. This study contributes to a better understanding of how electrophysiological synaptopathy metrics differ in ears with healthy and impaired audiograms, which is an important first step towards unravelling the perceptual consequences of synaptopathy.

Comparing the electrophysiological effects of traumatic noise exposure between rodents

2022 ◽  
Author(s):  
Lenneke Kiefer ◽  
Lisa Koch ◽  
Melisa Merdan-Desik ◽  
Bernhard H. Gaese ◽  
Manuela Nowotny
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Temporal Dynamics ◽  
Auditory Pathway ◽  
Auditory Brainstem ◽  
Individual Variability ◽  
Rodent Species ◽  
Waveform Analysis ◽  
Auditory Brainstem Responses ◽  
Noise Induced Hearing Loss

Noise-induced hearing deficits are important health problems in the industrialized world. As the underlying physiological dysfunctions are not well understood, research in suitable animal models is urgently needed. Three rodent species (Mongolian gerbil, rat and mouse) were studied to compare the temporal dynamics of noise-induced hearing loss after identical procedures of noise exposure. Auditory brainstem responses (ABRs) were measured before, during and up to eight weeks after noise exposure for threshold determination and ABR waveform analysis. Trauma induction with stepwise increasing sound pressure level was interrupted by five interspersed ABR measurements. Comparing short- and long-term dynamics underlying the following noise-induced hearing loss revealed diverging time courses between the three species. Hearing loss occurred early on during noise exposure in all three rodent species at or above trauma frequency. Initial noise level (105 dB SPL) was most effective in rats while the delayed level-increase to 115 dB SPL affected mice much stronger. Induced temporary threshold shifts in rats and mice were larger in animals with lower pre-trauma ABR thresholds. The increase in activity (gain) along the auditory pathway was derived by comparing the amplitudes of short- and long-latency ABR waveform components. Directly after trauma, significant effects were found for rats (decreasing gain) and mice (increasing gain) while gerbils revealed high individual variability in gain changes. Taken together, our comparative study revealed pronounced species-specific differences in the development of noise-induced hearing loss and the related processing along the auditory pathway.

scholarly journals Evoked auditory potentials from African mole-rats and coruros reveal disparity in subterranean rodent hearing

2021 ◽  
Author(s):  
Kai R. Caspar ◽  
Alexandra Heinrich ◽  
Lea Mellinghaus ◽  
Patricia Gerhardt ◽  
Sabine Begall
Keyword(s):  
Low Frequency ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Subterranean Rodents ◽  
Geological Time ◽  
Subterranean Rodent ◽  
Low Frequencies ◽  
Auditory Thresholds ◽  
Mole Rat ◽  
Low Sensitivity

Hearing in subterranean rodents exhibits numerous peculiarities, including low sensitivity and restriction to a narrow range of comparatively low frequencies. Past studies provided two conflicting hypotheses explaining how these derived traits evolved: structural degeneration and adaptive specialization. To further elucidate this issue, we recorded auditory brainstem responses from three species of social subterranean rodents that differ in the degree of specialization to the underground habitat: The naked mole-rat (Heterocephalus glaber) and the Mashona mole-rat (Fukomys darlingi) which represent the ancient lineage of African mole-rats (Bathyergidae) and the coruro (Spalacopus cyanus), a South American rodent (Octodontidae) which adopted a subterranean lifestyle in more recent geological time. Additionally, we measured call amplitudes of social vocalizations to study auditory vocal coupling. We found elevated auditory thresholds and severe low-frequency hearing range restrictions in the African mole-rats, with hearing in naked mole-rats tending to be more sensitive than in Mashona mole-rats. In contrast to that, hearing in coruros was similar to that of epigeic rodents, with its range extending into ultrasonic frequencies. However, as in the mole-rats, the coruros’ region of best hearing was located at low frequencies close to 1 kHz. We argue that the auditory sensitivity of African mole-rats, although remarkably poor, has been underestimated by recent studies, while data on coruros conform to previous results. Considering the available evidence, we propose to be open to both degenerative and adaptive interpretations of hearing physiology in subterranean mammals, as each may provide convincing explanations for specific auditory traits observed.

The Effect of Kalman-Weighted Averaging and Artifact Rejection on Residual Noise During Auditory Brainstem Response Testing

2019 ◽  
Vol 28 (1) ◽  
pp. 114-124
Author(s):  
Linda W. Norrix ◽  
Julie Thein ◽  
David Velenovsky
Keyword(s):  
Repeated Measures ◽  
Auditory Brainstem ◽  
Weighted Averaging ◽  
Auditory Brainstem Responses ◽  
Residual Noise ◽  
Electrophysiological Recordings ◽  
Artifact Rejection ◽  
Brainstem Response ◽  
Active Motor ◽  
Averaging Time

Purpose Low residual noise (RN) levels are critically important when obtaining electrophysiological recordings of threshold auditory brainstem responses. In this study, we examine the effectiveness and efficiency of Kalman-weighted averaging (KWA) implemented on the Vivosonic Integrity System and artifact rejection (AR) implemented on the Intelligent Hearing Systems SmartEP system for obtaining low RN levels. Method Sixteen adults participated. Electrophysiological measures were obtained using simultaneous recordings by the Vivosonic and Intelligent Hearing Systems for subjects in 2 relaxed conditions and 4 active motor conditions. Three averaging times were used for the relaxed states (1, 1.5, and 3 min) and for the active states (1.5, 3, and 6 min). Repeated-measures analyses of variance were used to examine RN levels as a function of noise reduction strategy (i.e., KWA, AR) and averaging time. Results Lower RN levels were obtained using KWA than AR in both the relaxed and active motor states. Thus, KWA was more effective than was AR under the conditions examined in this study. Using KWA, approximately 3 min of averaging was needed in the relaxed condition to obtain an average RN level of 0.025 μV. In contrast, in the active motor conditions, approximately 6 min of averaging was required using KWA. Mean RN levels of 0.025 μV were not attained using AR. Conclusions When patients are not physiologically quiet, low RN levels are more likely to be obtained and more efficiently obtained using KWA than AR. However, even when using KWA, in active motor states, 6 min of averaging or more may be required to obtain threshold responses. Averaging time needed and whether a low RN level can be attained will depend on the level of motor activity exhibited by the patient.

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