scholarly journals claudin-10 isoform expression and cation selectivity change with salinity in salt-secreting epithelia of Fundulusheteroclitus

2017 ◽  
Vol 221 (1) ◽  
pp. jeb168906 ◽  
Author(s):  
William S. Marshall ◽  
Jason P. Breves ◽  
Ellen M. Doohan ◽  
Christian K. Tipsmark ◽  
Scott P. Kelly ◽  
...  
Keyword(s):  
Cation Selectivity ◽  
Isoform Expression ◽  
Selectivity Change

Changes in CD44 isoform expression during inflammatory skin disease

1997 ◽  
Vol 22 (03) ◽  
pp. 128-133
Author(s):  
A.J. HARRIS ◽  
D. DEAN ◽  
S. BURGE ◽  
F. WOJNAROWSKA
Keyword(s):  
Skin Disease ◽  
Inflammatory Skin Disease ◽  
Inflammatory Skin ◽  
Isoform Expression

scholarly journals Glucocorticoid receptor isoform expression does not predict steroid treatment response in IBD

Gut ◽  
2007 ◽  
Vol 56 (9) ◽  
pp. 1328-1329 ◽  
Author(s):  
M Hausmann ◽  
H Herfarth ◽  
J Scholmerich ◽  
G Rogler
Keyword(s):  
Glucocorticoid Receptor ◽  
Treatment Response ◽  
Steroid Treatment ◽  
Isoform Expression

Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1

2004 ◽  
Vol 287 (5) ◽  
pp. C1282-C1291 ◽  
Author(s):  
James K. Bubien ◽  
Hong-Long Ji ◽  
G. Yancey Gillespie ◽  
Catherine M. Fuller ◽  
James M. Markert ◽  
...  
Keyword(s):  
Malignant Gliomas ◽  
Outward Current ◽  
Whole Cell ◽  
Amino Acid Peptide ◽  
Cation Selectivity ◽  
Astrocytoma Cells ◽  
Acid Sensing Ion Channels ◽  
Inward Currents ◽  
Cell Current ◽  
Peptide Toxin

Psalmotoxin 1 (a component of the venom of a West Indies tarantula) is a 40-amino acid peptide that inhibits cation currents mediated by acid-sensing ion channels (ASIC). In this study we performed electrophysiological experiments to test the hypothesis that Psalmotoxin 1 (PcTX1) inhibits Na+ currents in high-grade human astrocytoma cells (glioblastoma multiforme, or GBM). In whole cell patch-clamped cultured GBM cells, the peptide toxin quickly and reversibly inhibited both inward and outward current with an IC50 of 36 ± 2 pM. The same inhibition was observed in freshly resected GBM cells. However, when the same experiment was performed on normal human astrocytes, the toxin failed to inhibit the whole cell current. We also determined a cationic selectivity sequence for inward currents in three cultured GBM cell lines (SK-MG-1, U87-MG, and U251-MG). The selectivity sequence yielded a unique biophysical fingerprint with inward K+ conductance approximately fourfold greater than that of Na+, Li+, and Ca2+. These observations suggest that PcTX1 may prove useful in determining whether GBM cells express a specific ASIC-containing ion channel type that can serve as a target for both diagnostic and therapeutic treatments of aggressive malignant gliomas.

scholarly journals Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers

2021 ◽  
pp. 101163
Author(s):  
Jayanthi P. Gudikote ◽  
Tina Cascone ◽  
Alissa Poteete ◽  
Piyada Sitthideatphaiboon ◽  
Qiuyu Wu ◽  
...  
Keyword(s):  
P53 Pathway ◽  
Nonsense Mediated Decay ◽  
Isoform Expression

Differential Multidrug Resistance-Associated Protein 1 through 6 Isoform Expression and Function in Human Intestinal Epithelial Caco-2 Cells

2004 ◽  
Vol 311 (2) ◽  
pp. 476-484 ◽  
Author(s):  
Hannah M. Prime-Chapman ◽  
Richard A. Fearn ◽  
Anne E. Cooper ◽  
Vanessa Moore ◽  
Barry H. Hirst
Keyword(s):  
Multidrug Resistance ◽  
Intestinal Epithelial ◽  
Isoform Expression ◽  
And Function
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