Annual life-stage regulation of lipid metabolism and storage and association with PPARs in a migrant species: the gray catbird (Dumetella carolinensis)

2016 ◽  
Vol 219 (21) ◽  
pp. 3391-3398 ◽  
Author(s):  
Keely R. Corder ◽  
Kristen J. DeMoranville ◽  
David E. Russell ◽  
Janice M. Huss ◽  
Paul J. Schaeffer
Keyword(s):  
Lipid Metabolism ◽  
Life Stage ◽  
Dumetella Carolinensis ◽  
And Storage ◽  
Gray Catbird

scholarly journals Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage

2020 ◽  
Vol 61 (3) ◽  
pp. 422-431 ◽  
Author(s):  
Lahoucine Izem ◽  
Yan Liu ◽  
Richard E. Morton
Keyword(s):  
Lipid Metabolism ◽  
Lipid Droplets ◽  
Full Length ◽  
Intracellular Lipid ◽  
Transfer Protein ◽  
Lipid Phenotype ◽  
Exon 9 ◽  
And Storage

Cholesteryl ester transfer protein (CETP) exists as full-length (FL) and exon 9 (E9)-deleted isoforms. The function of E9-deleted CETP is poorly understood. Here, we investigated the role of E9-deleted CETP in regulating the secretion of FL-CETP by cells and explored its possible role in intracellular lipid metabolism. CETP overexpression in cells that naturally express CETP confirmed that E9-deleted CETP is not secreted, and showed that cellular FL- and E9-deleted CETP form an isolatable complex. Coexpression of CETP isoforms lowered cellular levels of both proteins and impaired FL-CETP secretion. These effects were due to reduced synthesis of both isoforms; however, the predominate consequence of FL- and E9-deleted CETP coexpression is impaired FL-CETP synthesis. We reported previously that reducing both CETP isoforms or overexpressing FL-CETP impairs cellular triglyceride (TG) storage. To investigate this further, E9-deleted CETP was expressed in SW872 cells that naturally synthesize CETP and in mouse 3T3-L1 cells that do not. E9-deleted CETP overexpression stimulated SW872 triglyceride synthesis and increased stored TG 2-fold. Expression of E9-deleted CETP in mouse 3T3-L1 cells produced a similar lipid phenotype. In vitro, FL-CETP promotes the transfer of TG from ER-enriched membranes to lipid droplets. E9-deleted CETP also promoted this transfer, although less effectively, and it inhibited the transfer driven by FL-CETP. We conclude that FL- and E9-deleted CETP isoforms interact to mutually decrease their intracellular levels and impair FL-CETP secretion by reducing CETP biosynthesis. E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner.

Effect of dietary cadmium on lipid metabolism and storage of aquatic bird Cairina moschata

Ecotoxicology ◽  
2009 ◽  
Vol 19 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Magali Lucia ◽  
Jean-Marc André ◽  
Patrice Gonzalez ◽  
Magalie Baudrimont ◽  
Marie-Dominique Bernadet ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Aquatic Bird ◽  
Cairina Moschata ◽  
Dietary Cadmium ◽  
And Storage

Sampling.

2021 ◽  
pp. 1-11
Author(s):  
Loes J. M. F. den Nijs ◽  
Jon Pickup ◽  
Ralf-Udo Ehlers
Keyword(s):  
Entomopathogenic Nematodes ◽  
Developmental Stages ◽  
Life Stage ◽  
Sampling Techniques ◽  
And Storage ◽  
Plant Parasitic

Abstract Nematodes can be present in various parts of plants or at various depths in the soil, depending on the circumstances and the life stage. This means that one should be aware of these possibilities when collecting samples. Also, samples should be taken from the proper matrix at the appropriate time, taking into account the developmental stages the nematodes might be in. In this chapter, the purpose of sampling, sampling techniques and, related to this, the sampling tools, and the handling and storage of the samples before processing of plant-parasitic and entomopathogenic nematodes are discussed. Some protocols are described in detail as examples.

Gray Catbird (Dumetella carolinensis)

1995 ◽  
Author(s):  
David A. Cimprich ◽  
Frank R. Moore
Keyword(s):  
Dumetella Carolinensis ◽  
Gray Catbird

scholarly journals Split-ends is modulating lipid droplet content in adult Drosophila glial cells and is protective against paraquat toxicity

2020 ◽  
Author(s):  
Victor Girard ◽  
Valérie Goubard ◽  
Matthieu Querenet ◽  
Laurent Seugnet ◽  
Laurent Pays ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Glial Cells ◽  
Lipid Droplets ◽  
Notch Pathway ◽  
Mrna Levels ◽  
Data Mining Approach ◽  
Paraquat Toxicity ◽  
Human Ortholog ◽  
And Storage ◽  
Adult Drosophila

ABSTRACTGlial cells are early sensors of neuronal injury and are able to store lipids in lipid droplets under oxidative stress conditions. Here, we investigated the glial functions of Spen in the context of Parkinson’s disease (PD). Using a data mining approach, we first found that the human ortholog of spen, SPEN/SHARP belongs to the set of astrocyte-expressed genes which mRNA levels are significantly different in the substantia nigra of PD patients as compared to controls. Interestingly, the retrieved list of differentially expressed genes was enriched in genes involved in lipid metabolism. In a Drosophila model of PD, we observed that spen mutant flies were more sensitive to paraquat intoxication. Moreover, the glia-restricted knockdown of spen led to the expansion and the accumulation of lipid droplets as well as the inhibition of Notch pathway. Taken together our results show that Spen regulates lipid metabolism and storage in glial cells and by these means contribute to glia-mediated functions in the context of neurodegeneration.

scholarly journals Myriocin modulates the altered lipid metabolism and storage in cystic fibrosis

2021 ◽  
Vol 81 ◽  
pp. 109928
Author(s):  
Paola Signorelli ◽  
Francesca Pivari ◽  
Matteo Barcella ◽  
Ivan Merelli ◽  
Aida Zulueta ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lipid Metabolism ◽  
And Storage ◽  
Altered Lipid Metabolism ◽  
Altered Lipid
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