scholarly journals Osmoregulation, bioenergetics and oxidative stress in coastal marine invertebrates: raising the questions for future research

2017 ◽  
Vol 220 (10) ◽  
pp. 1749-1760 ◽  
Author(s):  
Georgina A. Rivera-Ingraham ◽  
Jehan-Hervé Lignot
Keyword(s):  
Oxidative Stress ◽  
Marine Invertebrates ◽  
Future Research ◽  
Coastal Marine ◽  
And Oxidative Stress

scholarly journals Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma

2021 ◽  
Author(s):  
Sinan Xiong ◽  
Wee-Joo Chng ◽  
Jianbiao Zhou
Keyword(s):  
Oxidative Stress ◽  
Multiple Myeloma ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Cell Fate ◽  
Stress Responses ◽  
Plasma Cells ◽  
Reactive Oxygen Species Generation ◽  
Future Research ◽  
And Oxidative Stress

AbstractUnder physiological and pathological conditions, cells activate the unfolded protein response (UPR) to deal with the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum. Multiple myeloma (MM) is a hematological malignancy arising from immunoglobulin-secreting plasma cells. MM cells are subject to continual ER stress and highly dependent on the UPR signaling activation due to overproduction of paraproteins. Mounting evidence suggests the close linkage between ER stress and oxidative stress, demonstrated by overlapping signaling pathways and inter-organelle communication pivotal to cell fate decision. Imbalance of intracellular homeostasis can lead to deranged control of cellular functions and engage apoptosis due to mutual activation between ER stress and reactive oxygen species generation through a self-perpetuating cycle. Here, we present accumulating evidence showing the interactive roles of redox homeostasis and proteostasis in MM pathogenesis and drug resistance, which would be helpful in elucidating the still underdefined molecular pathways linking ER stress and oxidative stress in MM. Lastly, we highlight future research directions in the development of anti-myeloma therapy, focusing particularly on targeting redox signaling and ER stress responses.

scholarly journals Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress

2021 ◽  
Vol 12 ◽  
Author(s):  
Ling Li ◽  
Ya-Li Zhang ◽  
Xing-Yu Liu ◽  
Xiang Meng ◽  
Rong-Quan Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Inflammatory Mediators ◽  
Systemic Disease ◽  
Elevated Serum ◽  
Future Research ◽  
Oral Flora ◽  
Periodontal Inflammation ◽  
And Oxidative Stress

Periodontitis is a type of systemic immune inflammation that is caused by the complex infection of a variety of microorganisms in the subgingival plaque and the imbalance of the microbial ecological environment in the mouth. Periodontitis and chronic kidney disease (CKD) share many risk factors, such as obesity, smoking, and age. A growing body of data supports a strong correlation between periodontitis and kidney disease. Evidence supports the role of periodontal inflammation and elevated serum inflammatory mediators in renal atherosclerosis, renal deterioration, and end-stage renal disease (ESRD) development. Periodontitis is a risk factor for kidney disease. However, to our knowledge, there are few studies detailing the possible link between periodontitis and CKD. This review summarizes the possible mechanisms underlying periodontitis and CKD. More importantly, it highlights novel and potential pathogenic factors for CKD, including bacteria, pro-inflammatory mediators and oxidative stress. However, most research on the relationship between periodontitis and systemic disease has not determined causality, and these diseases are largely linked by bidirectional associations. Future research will focus on exploring these links to contribute to new treatments for CKD.

scholarly journals Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

2008 ◽  
Vol 36 (5) ◽  
pp. 1045-1050 ◽  
Author(s):  
Naila Rabbani ◽  
Paul J. Thornalley
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Life Extension ◽  
Mitochondrial Proteins ◽  
Future Research ◽  
Oxygen Species ◽  
Nematode Caenorhabditis Elegans ◽  
Mitochondrial Proteome ◽  
And Oxidative Stress ◽  
Preceding Event

Protection of mitochondrial proteins from glycation by endogenous dicarbonyl compounds, methylglyoxal and glyoxal, was found recently to prevent increased formation of reactive oxygen species and oxidative and nitrosative damage to the proteome during aging and produce life extension in the nematode Caenorhabditis elegans. This suggests that dicarbonyl glycation damage to the mitochondrial proteome may be a preceding event to mitochondrial dysfunction leading to oxidative stress. Future research will address the functional charges in mitochondrial proteins that are the targets for dicarbonyl glycation.

Mechanisms of disuse muscle atrophy: role of oxidative stress

2005 ◽  
Vol 288 (2) ◽  
pp. R337-R344 ◽  
Author(s):  
Scott K. Powers ◽  
Andreas N. Kavazis ◽  
Keith C. DeRuisseau
Keyword(s):  
Oxidative Stress ◽  
Muscle Atrophy ◽  
Cell Biology ◽  
Muscle Protein ◽  
Reactive Oxygen ◽  
Future Research ◽  
Exciting Field ◽  
Disuse Muscle Atrophy ◽  
And Oxidative Stress

Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of those factors that contribute to muscle atrophy. To this end, abundant evidence implicates oxidative stress as a potential regulator of proteolytic pathways leading to muscle atrophy during periods of prolonged disuse. This review will address the role of reactive oxygen species and oxidative stress as potential contributors to the process of disuse-mediated muscle atrophy. The first section of this article will discuss our current understanding of muscle proteases, sources of reactive oxygen in muscle fibers, and the evidence linking oxidative stress to disuse muscle atrophy. The second section of this review will highlight gaps in our knowledge relative to the specific role of oxidative stress in the regulation of disuse muscle atrophy. By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field.

scholarly journals The Influence of Season Variation on Hematological Parameters and Oxidative Stress for Rainbow Trout (Oncorhynchus mykiss)

2018 ◽  
Vol 75 (1) ◽  
pp. 11 ◽  
Author(s):  
Andrada IHUŢ ◽  
Camelia RĂDUCU ◽  
Călin LAŢIU ◽  
Daniel COCAN ◽  
Paul UIUIU ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oncorhynchus Mykiss ◽  
Hematological Parameters ◽  
Summer Season ◽  
Future Research ◽  
Spring Season ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Pathological Conditions ◽  
Fish Response ◽  
And Oxidative Stress

The parameters studied were RBC, Ht, Hb, erythrocyte index MCV, MCH, MCHC, and oxidative stress through SOD and GPx. For each parameter, blood samples were collected at specimens weighing between 100-140g in the summer season, 250-280 g in the fall, 270-300g in the winter and 320-350g in the spring. At the specimens studied the highest values of GPx and SOD were recorded in the spring season due to the stress caused by massive precipitation. During the study, the water temperature ranged between 5.1° C in winter and 19.2° C in summer and O2 ranged between 8.30 mg/l in the summer and 10.20 mg / l in winter. For most parameters, the highest values were recorded in the spring season and the lowest in the summer season. The data obtained in each season on Oncorhynchus mykiss species do not indicate pathological conditions but more an adaptive fish response to environmental conditions and can serve as a database for future research on welfare of salmonids.

scholarly journals The cardiovascular complications of diabetes: a striking link through protein glycation

2020 ◽  
Vol 58 (4) ◽  
pp. 188-198
Author(s):  
Mousa Numan Ahmad ◽  
Amani Ibrahim Farah ◽  
Tareq Musbah Al-Qirim
Keyword(s):  
Oxidative Stress ◽  
Enzymatic Reaction ◽  
Cardiovascular Complications ◽  
Cardiac Cells ◽  
Protein Glycation ◽  
Future Research ◽  
Diabetic Patients ◽  
Mortality And Morbidity ◽  
Glycation End Products ◽  
And Oxidative Stress

AbstractDiabetes mellitus is a predominant cause of mortality and morbidity worldwide. One of its serious health problems is cardiovascular complications. Advanced glycation end products (AGEs) are a group of heterogeneous toxic oxidant compounds that are formed after a non-enzymatic reaction between monosaccharides and free amino groups of proteins, compound lipids, and nucleic acids. AGE interacts with various types of cells through a receptor for AGE (RAGE). The interaction between AGE and RAGE is responsible for a cascade of inflammation, oxidative stress, and disruption of calcium homeostasis in cardiac cells of diabetic patients. There is striking evidence that the AGE/RAGE axis with its consequences on inflammation and oxidative stress plays a major role in the development of cardiovascular complications. Therefore, considering AGE as a therapeutic target with foreseeable results would be a wise direction for future research. Interestingly, several studies on nutraceutical, pharmaceutical, and natural products have begun to reveal promising therapeutic results, and this could lead to better health outcomes for many diabetic patients worldwide. This article discusses the current literature addressing the connection between protein glycation and diabetes cardiovascular complications and suggests future avenues of research.

scholarly journals Oxidative stress, protein glycation and nutrition – interactions relevant to health and disease throughout the lifecycle

2014 ◽  
Vol 73 (3) ◽  
pp. 430-438 ◽  
Author(s):  
Antonis Vlassopoulos ◽  
Michael E. J. Lean ◽  
Emilie Combet
Keyword(s):  
Oxidative Stress ◽  
Stress Protein ◽  
Redox Status ◽  
Protein Glycation ◽  
Future Research ◽  
Diabetes Diagnosis ◽  
Gold Standard Method ◽  
Health And Disease ◽  
And Oxidative Stress

Protein glycation has been studied for over a century now and plays an important role in disease pathogenesis throughout the lifecycle. Strongly related to diabetic complications, glycation of Hb has become the gold standard method for diabetes diagnosis and monitoring. It is however attracting attention in normoglycaemia as well lately. Longitudinal studies increasingly suggest a positive relationship between glycation and the risk of chronic diseases in normoglycaemic individuals, but the mechanisms behind this association remain unclear. The interaction between glycation and oxidative stress may be particularly relevant in the normoglycaemic context, as suggested by recent epidemiological and in vitro evidence. In that context nutritional and lifestyle factors with an influence on redox status, such as smoking, fruit and vegetable and antioxidants consumption, may have the capacity to promote or inhibit glycation. However, experimental data from controlled trials are lacking the quality and rigour needed to reach firm conclusions. In the present review, we discuss the importance of glycation for health through the lifecycle and focus on the importance of oxidative stress as a driver for glycation. The importance of nutrition to modulate glycation is discussed, based on the evidence available and recommendations towards higher quality future research are made.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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