scholarly journals The regulatory role of the NO/cGMP signal transduction cascade during larval attachment and metamorphosis of the barnacle Balanus (=Amphibalanus) amphitrite

2012 ◽  
Vol 215 (21) ◽  
pp. 3813-3822 ◽  
Author(s):  
Y. Zhang ◽  
L.-S. He ◽  
G. Zhang ◽  
Y. Xu ◽  
O.-O. Lee ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Regulatory Role ◽  
Signal Transduction Cascade ◽  
Cgmp Signal ◽  
Larval Attachment

Opioid regulation of gonadotropin release: role of signal transduction cascade

2000 ◽  
Vol 52 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Poonam Sharma ◽  
Sanjeev Kumar Bhardwaj ◽  
Sukhjit Kaur Sandhu ◽  
Gurcharan Kaur
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Cascade ◽  
Gonadotropin Release

Impact of diabetes on CNS: Role of signal transduction cascade

1999 ◽  
Vol 49 (3) ◽  
pp. 155-162 ◽  
Author(s):  
Sanjeev Kumar Bhardwaj ◽  
Sukhjit Kaur Sandhu ◽  
Poonam Sharma ◽  
Gurcharan Kaur
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Cascade

scholarly journals The miR-9b microRNA mediates dimorphism and development of wing in aphids

2020 ◽  
Vol 117 (15) ◽  
pp. 8404-8409 ◽  
Author(s):  
Feng Shang ◽  
Jinzhi Niu ◽  
Bi-Yue Ding ◽  
Wei Zhang ◽  
Dan-Dan Wei ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Signaling Pathway ◽  
Acyrthosiphon Pisum ◽  
Environmental Cues ◽  
Regulation Mechanism ◽  
Wing Development ◽  
Wing Dimorphism ◽  
Regulatory Relationship ◽  
Signal Transduction Cascade

Wing dimorphism is a phenomenon of phenotypic plasticity in aphid dispersal. However, the signal transduction for perceiving environmental cues (e.g., crowding) and the regulation mechanism remain elusive. Here, we found that aci-miR-9b was the only down-regulated microRNA (miRNA) in both crowding-induced wing dimorphism and during wing development in the brown citrus aphid Aphis citricidus. We determined a targeted regulatory relationship between aci-miR-9b and an ABC transporter (AcABCG4). Inhibition of aci-miR-9b increased the proportion of winged offspring under normal conditions. Overexpression of aci-miR-9b resulted in decline of the proportion of winged offspring under crowding conditions. In addition, overexpression of aci-miR-9b also resulted in malformed wings during wing development. This role of aci-miR-9b mediating wing dimorphism and development was also confirmed in the pea aphid Acyrthosiphon pisum. The downstream action of aci-miR-9b-AcABCG4 was based on the interaction with the insulin and insulin-like signaling pathway. A model for aphid wing dimorphism and development was demonstrated as the following: maternal aphids experience crowding, which results in the decrease of aci-miR-9b. This is followed by the increase of ABCG4, which then activates the insulin and insulin-like signaling pathway, thereby causing a high proportion of winged offspring. Later, the same cascade, “miR-9b-ABCG4-insulin signaling,” is again involved in wing development. Taken together, our results reveal that a signal transduction cascade mediates both wing dimorphism and development in aphids via miRNA. These findings would be useful in developing potential strategies for blocking the aphid dispersal and reducing viral transmission.

GABAAand GABACreceptor antagonists increase retinal cyclic GMP levels through nitric oxide synthase

2003 ◽  
Vol 20 (6) ◽  
pp. 627-637 ◽  
Author(s):  
DOU YU ◽  
WILLIAM D. ELDRED
Keyword(s):  
Nitric Oxide ◽  
Signal Transduction ◽  
Receptor Antagonist ◽  
Cyclic Gmp ◽  
Gaba Receptor ◽  
Signal Transduction Pathway ◽  
Receptor Antagonists ◽  
Cgmp Signal ◽  
Oxide Synthase

The nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signal transduction pathway plays a role in every retinal cell type. Previous studies have shown that excitatory glutamatergic synaptic pathways can increase cGMP-like immunoreactivity (cGMP-LI) in retina through stimulation of NO production, but little is known about the role of synaptic inhibition in the modulation of cGMP-LI. Gamma-amino-n-butyric acid (GABA) plays critical roles in modulating excitatory synaptic pathways in the retina. Therefore, we used GABA receptor antagonists to explore the role of GABAergic inhibitory synaptic pathways on the modulation of the NO/cGMP signal-transduction system. Cyclic GMP immunocytochemistry was used to investigate the effects of the GABA receptor antagonists bicuculline, picrotoxin, and (1,2,5,6-tetrahyropyridin-4-yl) methylphosphinic acid (TPMPA) on levels of cGMP-LI. Cyclic GMP-LI was strongly increased in response to the GABAAreceptor antagonist bicuculline, while the GABACreceptor antagonist TPMPA had little effect on cGMP-LI. The GABAA/GABACreceptor antagonist, picrotoxin, caused a moderate increase in cGMP-LI, which was mimicked by the combination of bicuculline and TPMPA. The nitric oxide synthase inhibitor, S-methyl-L-thiocitrulline (SMTC), blocked the increased cGMP-LI in response to stimulation with either bicuculline or picrotoxin. Treatments with either of the glutamate receptor antagonists (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) partially blocked the increases in cGMP-LI seen in response to bicuculline, but a combination of MK-801 and CNQX completely eliminated these increases. These results suggest that inhibitory synaptic pathways involving both types of GABA receptors work through excitatory glutamatergic receptors to regulate the NO/cGMP signal-transduction pathway in retina.

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