scholarly journals Fuel switching and energy partitioning during the postprandial metabolic response in the ball python (Python regius)

2010 ◽  
Vol 213 (8) ◽  
pp. 1266-1271 ◽  
Author(s):  
S. Waas ◽  
R. A. Werner ◽  
J. M. Starck
Keyword(s):  
Metabolic Response ◽  
Energy Partitioning ◽  
Python Regius ◽  
Fuel Switching

Abstract MP105: Python Post-prandial Cardiac Adaptation is Supported by Enhanced Metabolism, Reduced Sarcomere Passive Tension, and Epigenetic Remodeling

2020 ◽  
Vol 127 (Suppl_1) ◽  
Author(s):  
Claudia Crocini ◽  
Kc Woulfe ◽  
Cierra J Walker ◽  
Christopher D Ozeroff ◽  
leslie A leinwand
Keyword(s):  
Metabolic Response ◽  
Heart Diseases ◽  
Chromatin Condensation ◽  
Chromatin Accessibility ◽  
Passive Tension ◽  
Tissue Stiffness ◽  
Atp Production ◽  
Python Regius ◽  
Cardiac Adaptation ◽  
Epigenetic Remodeling

Pythons are infrequent feeders that can ingest meals equal to their own body mass. The extreme metabolic response required to digest such large meals is associated with a dramatic increase in the mass of most organs, including the heart. Recently, we have been able to assess functional effects of feeding using isolated python cardiomyocytes and myofibrils, advancing our understanding of extreme cardiac adaptation in python ( Python regius ). Twenty-four hours after feeding, python cardiomyocytes showed prolonged Ca 2+ transients, increased maximal tension and Ca 2+ sensitivity of myofibrils as compared to fasted pythons. Post-prandial positive inotropy was accompanied by enhanced metabolic output via increased mitochondrial ATP production rate and by AMP-dependent kinase (AMPK) activation and phosphofructokinase-2 reduction, suggesting a key role for fatty acid, but not glucose, metabolism after feeding. In addition, 24h post-fed hearts had significantly reduced tissue stiffness and myofibril passive tension. Finally, chromatin condensation was reduced about 30% after feeding in python cardiomyocytes and confirmed by increased histone acetylation, indicating a predominant role for epigenetics in post-prandial adaptation. These results suggest that feeding promotes positive cardiac inotropy in python via a number of coordinated mechanisms to enhance energy production, increase myofibril and tissue compliance, and increase chromatin accessibility. As heart failure is commonly characterized by depressed contractility, compromised energetics, and increased tissue stiffness, assessing post-prandial adaptation in python hearts provides us with powerful insights that could inform the development of therapeutics for human heart diseases.

Role of FGF21 and GCN2 in mediating the metabolic response to dietary protein restriction

2016 ◽  
Vol 11 (S 01) ◽  
Author(s):  
T Laeger ◽  
DC Albarado ◽  
L Trosclair ◽  
J Hedgepeth ◽  
CD Morrison
Keyword(s):  
Dietary Protein ◽  
Metabolic Response ◽  
Protein Restriction ◽  
Dietary Protein Restriction

1950-P: Fat Mass Affects Metabolic Response to Erythropoietin in Mice

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1950-P
Author(s):  
HEATHER ROGERS ◽  
CONSTANCE T. NOGUCHI
Keyword(s):  
Fat Mass ◽  
Metabolic Response

Effect of diabetes mellitus and insulin on the turnover and metabolic response to ketones in man

Diabetes ◽  
1976 ◽  
Vol 25 (9) ◽  
pp. 776-784 ◽  
Author(s):  
R. S. Sherwin ◽  
R. G. Hendler ◽  
P. Felig
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Response

1098 Yeast supplementation altered the metabolic response to a combined viral-bacterial challenge in feedlot heifers

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 526-526 ◽  
Author(s):  
A. B. Word ◽  
P. R. Broadway ◽  
N. C. Burdick Sanchez ◽  
K. P. Sharon ◽  
S. L. Roberts ◽  
...  
Keyword(s):  
Metabolic Response ◽  
Bacterial Challenge
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