scholarly journals Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Gunther 1867)

2007 ◽  
Vol 210 (5) ◽  
pp. 825-835 ◽  
Author(s):  
B. L. Symonds ◽  
R. S. James ◽  
C. E. Franklin
Keyword(s):  
Skeletal Muscle ◽  
Disuse Atrophy ◽  
Muscle Disuse ◽  
Contractile Performance

scholarly journals Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice

2017 ◽  
Vol 312 (5) ◽  
pp. E394-E406 ◽  
Author(s):  
Samuel Lee ◽  
Teresa C. Leone ◽  
Lisa Rogosa ◽  
John Rumsey ◽  
Julio Ayala ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Early Stage ◽  
Peroxisome Proliferator ◽  
Disuse Atrophy ◽  
Proof Of Concept ◽  
Peroxisome Proliferator Activated Receptor ◽  
Muscle Disuse ◽  
Training Response

Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and -1β serve as master transcriptional regulators of muscle mitochondrial functional capacity and are capable of enhancing muscle endurance when overexpressed in mice. We sought to determine whether muscle-specific transgenic overexpression of PGC-1β affects the detraining response following endurance training. First, we established and validated a mouse exercise-training-detraining protocol. Second, using multiple physiological and gene expression end points, we found that PGC-1β overexpression in skeletal muscle of sedentary mice fully recapitulated the training response. Lastly, PGC-1β overexpression during the detraining period resulted in partial prevention of the detraining response. Specifically, an increase in the plateau at which O2 uptake (V̇o2) did not change from baseline with increasing treadmill speed [peak V̇o2 (ΔV̇o2max)] was maintained in trained mice with PGC-1β overexpression in muscle 6 wk after cessation of training. However, other detraining responses, including changes in running performance and in situ half relaxation time (a measure of contractility), were not affected by PGC-1β overexpression. We conclude that while activation of muscle PGC-1β is sufficient to drive the complete endurance phenotype in sedentary mice, it only partially prevents the detraining response following exercise training, suggesting that the process of endurance detraining involves mechanisms beyond the reversal of muscle autonomous mechanisms involved in endurance fitness. In addition, the protocol described here should be useful for assessing early-stage proof-of-concept interventions in preclinical models of muscle disuse atrophy.

scholarly journals Omega‐3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women

2019 ◽  
Vol 33 (3) ◽  
pp. 4586-4597 ◽  
Author(s):  
Chris Mcglory ◽  
Stefan H. M. Gorissen ◽  
Michael Kamal ◽  
Ravninder Bahniwal ◽  
Amy J. Hector ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Young Women ◽  
Disuse Atrophy ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid ◽  
Muscle Disuse

Testosterone suppression does not exacerbate disuse atrophy and impairs muscle recovery that is not rescued by high protein

2020 ◽  
Vol 129 (1) ◽  
pp. 5-16 ◽  
Author(s):  
Erik D. Hanson ◽  
Andrew C. Betik ◽  
Cara A. Timpani ◽  
John Tarle ◽  
Xinmei Zhang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adverse Effects ◽  
Muscle Mass ◽  
Caloric Intake ◽  
Disuse Atrophy ◽  
Muscle Recovery ◽  
Testosterone Levels ◽  
Muscle Disuse ◽  
Low Testosterone ◽  
And Function

Low testosterone levels during skeletal muscle disuse did not worsen declines in muscle mass and function, although hypogonadism may attenuate recovery during subsequent reloading. Diets high in casein did not improve outcomes during immobilization or reloading. Practical strategies are needed that do not compromise caloric intake yet provide effective protein doses to augment these adverse effects.

scholarly journals Skeletal Muscle Disuse Atrophy Is Not Attenuated by Dietary Protein Supplementation in Healthy Older Men

2014 ◽  
Vol 144 (8) ◽  
pp. 1196-1203 ◽  
Author(s):  
Marlou L. Dirks ◽  
Benjamin T. Wall ◽  
Rachel Nilwik ◽  
Daniëlle H.J.M. Weerts ◽  
Lex B. Verdijk ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Dietary Protein ◽  
Older Men ◽  
Protein Supplementation ◽  
Disuse Atrophy ◽  
Muscle Disuse

Molecular Signatures Associated with Skeletal Muscle Disuse Atrophy in Humans

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S52-S53
Author(s):  
Krista Vandenborne ◽  
Chris M. Gregory ◽  
Glenn A. Walter ◽  
Rongye Shi ◽  
Mark T. Scarborough ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Molecular Signatures ◽  
Disuse Atrophy ◽  
Muscle Disuse

scholarly journals Aging Affects the Transcriptional Regulation of Human Skeletal Muscle Disuse Atrophy

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51238 ◽  
Author(s):  
Charlotte Suetta ◽  
Ulrik Frandsen ◽  
Line Jensen ◽  
Mette Munk Jensen ◽  
Jakob G. Jespersen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Transcriptional Regulation ◽  
Human Skeletal Muscle ◽  
Disuse Atrophy ◽  
Muscle Disuse

scholarly journals Phosphoproteomic identification of Xin as a novel requirement for skeletal muscle disuse atrophy

2019 ◽  
Author(s):  
Zhencheng Li ◽  
Pia Jensen ◽  
Johanna Abrigo ◽  
Carlos Henriquez-Olguin ◽  
Molly Gingrich ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Skeletal Muscle ◽  
Tibialis Anterior Muscle ◽  
Adaptor Protein ◽  
Disuse Atrophy ◽  
Cast Immobilization ◽  
Post Translational Modifications ◽  
Novel Proteins ◽  
Muscle Disuse

AbstractBackgroundImmobilization of skeletal muscle in a stretched position is associated with marked protection against disuse atrophy. Some intramyocellular changes in known proteins and post-translational modifications were previously linked to this phenomenon but there are likely many presently unknown proteins and post-translational modifications that contribute to this beneficial effect.MethodsTo identify novel proteins and phosphorylation events involved in stretch-induced reduction of disuse atrophy, we conducted a global unbiased screen of the changes occurring in skeletal muscle in control vs. 1 day and 1 week stretched cast-immobilized mouse tibialis anterior muscle, using quantitative tandem mass spectrometry on HILIC-fractionated muscle peptides with follow-up studies in transgenic mice and humans.ResultsOur mass spectrometry analyses detected 11714 phosphopeptides and 2081 proteins, of which 53 phosphopeptides and 5 proteins, 125 phosphopeptides and 43 proteins were deregulated after 1D and 7D of stretched immobilization, respectively. The sarcomere and muscle tendinous junction-associated putative multi-adaptor protein Xin was among the most highly upregulated proteins both in terms of phosphorylation and protein expression and was confirmed to increase with stretch but not disuse atrophy in mice and to increase and decrease with exercise and cast immobilization, respectively, in humans. Xin-/- mice were partially protected against disuse but not denervation atrophy in both stretched and flexed immobilized muscles compared to WT.ConclusionThis study identified Xin as a novel protein involved in disuse atrophy and also provides a resource to guide future hypothesis-driven investigations into uncovering critical factors in the protection against disuse atrophy.

scholarly journals PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging

2020 ◽  
Vol 17 (22) ◽  
pp. 8650
Author(s):  
Jonathan J. Petrocelli ◽  
Micah J. Drummond
Keyword(s):  
Skeletal Muscle ◽  
Sirtuin 1 ◽  
Future Application ◽  
Peroxisome Proliferator ◽  
Disuse Atrophy ◽  
Older Individuals ◽  
Muscle Recovery ◽  
Peroxisome Proliferator Activated Receptor ◽  
Muscle Disuse ◽  
Amp Activated Protein Kinase

Impaired muscle recovery (size and strength) following a disuse period commonly occurs in older adults. Many of these individuals are not able to adequately exercise due to pain and logistic barriers. Thus, nutritional and pharmacological therapeutics, that are translatable, are needed to promote muscle recovery following disuse in older individuals. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may be a suitable therapeutic target due to pleiotropic regulation of skeletal muscle. This review focuses on nutritional and pharmacological interventions that target PGC-1α and related Sirtuin 1 (SIRT1) and 5′ AMP-activated protein kinase (AMPKα) signaling in muscle and thus may be rapidly translated to prevent muscle disuse atrophy and promote recovery. In this review, we present several therapeutics that target PGC-1α in skeletal muscle such as leucine, β-hydroxy-β-methylbuyrate (HMB), arginine, resveratrol, metformin and combination therapies that may have future application to conditions of disuse and recovery in humans.

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