scholarly journals A new paradigm for ammonia excretion in aquatic animals: role of Rhesus (Rh) glycoproteins

2009 ◽  
Vol 212 (15) ◽  
pp. 2303-2312 ◽  
Author(s):  
P. A. Wright ◽  
C. M. Wood
Keyword(s):  
Ammonia Excretion ◽  
New Paradigm ◽  
Aquatic Animals ◽  
Rh Glycoproteins

scholarly journals Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis

2014 ◽  
Vol 306 (4) ◽  
pp. F389-F400 ◽  
Author(s):  
Hyun-Wook Lee ◽  
Jill W. Verlander ◽  
Mary E. Handlogten ◽  
Ki-Hwan Han ◽  
I. David Weiner
Keyword(s):  
Metabolic Acidosis ◽  
Collecting Duct ◽  
Ammonia Excretion ◽  
Severe Metabolic Acidosis ◽  
Urine Ph ◽  
Renal Response ◽  
Rh Glycoproteins ◽  
Acid Loading ◽  
Specific Deletion

The Rhesus (Rh) glycoproteins, Rh B and Rh C Glycoprotein (Rhbg and Rhcg, respectively), are ammonia-specific transporters expressed in renal distal nephron and collecting duct sites that are necessary for normal rates of ammonia excretion. The purpose of the current studies was to determine the effect of their combined deletion from the renal collecting duct (CD-Rhbg/Rhcg-KO) on basal and acidosis-stimulated acid-base homeostasis. Under basal conditions, urine pH and ammonia excretion and serum HCO3− were similar in control (C) and CD-Rhbg/Rhcg-KO mice. After acid-loading for 7 days, CD-Rhbg/Rhcg-KO mice developed significantly more severe metabolic acidosis than did C mice. Acid loading increased ammonia excretion, but ammonia excretion increased more slowly in CD-Rhbg/Rhcg-KO and it was significantly less than in C mice on days 1–5. Urine pH was significantly more acidic in CD-Rhbg/Rhcg-KO mice on days 1, 3, and 5 of acid loading. Metabolic acidosis increased phosph enolpyruvate carboxykinase (PEPCK) and Na+/H+ exchanger NHE-3 and decreased glutamine synthetase (GS) expression in both genotypes, and these changes were significantly greater in CD-Rhbg/Rhcg-KO than in C mice. We conclude that 1) Rhbg and Rhcg are critically important in the renal response to metabolic acidosis; 2) the significantly greater changes in PEPCK, NHE-3, and GS expression in acid-loaded CD-Rhbg/Rhcg-KO compared with acid-loaded C mice cause the role of Rhbg and Rhcg to be underestimated quantitatively; and 3) in mice with intact Rhbg and Rhcg expression, metabolic acidosis does not induce maximal changes in PEPCK, NHE-3, and GS expression despite the presence of persistent metabolic acidosis.

INOVASI PEMBELAJARAN AKIDAH AKHLAK MENGGUNAKAN METODE ROLE PLAY DALAM MENINGKATKAN PRESTASI BELAJAR SISWA

2018 ◽  
Vol 2 (1) ◽  
pp. 52-63
Author(s):  
Ansori Ansori
Keyword(s):  
Data Reduction ◽  
Role Play ◽  
Learning Goals ◽  
New Paradigm ◽  
Learning Materials ◽  
Analysis Technique ◽  
Flexible Schedule ◽  
Using Data ◽  
Real Action

The use of various methods will greatly help students in achieving learning goals. As role play method is one way mastery of learning materials through the development of imagination and appreciation of students on learning materials. Data collection techniques in this study are observation, interviews, and documentation. To analyze the data in this research using data analysis technique of Miles and Huberman model that is data reduction (Data Reduction), data presentation (Data Display) and conclusion (Conclution Drawing / verification) The findings in this research is innovation of role play method can change paradigm to the new paradigm so that the role of the teacher is more as a facilitator, counselor, consultant, and comrade study Flexible schedule, open as needed Learning directed by students themselves Problem-based, project, real world, real action, and reflection Design and investigation. Computers as tools, and dynamic media presentations.

scholarly journals The Gene Regulatory Roles of Herbal Extracts on the Growth, Immune System, and Reproduction of Fish

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2167
Author(s):  
Ehsan Ahmadifar ◽  
Hamideh Pourmohammadi Fallah ◽  
Morteza Yousefi ◽  
Mahmoud A. O. Dawood ◽  
Seyed Hossein Hoseinifar ◽  
...  
Keyword(s):  
Immune System ◽  
Mode Of Action ◽  
Medicinal Herbs ◽  
Environmental Stressors ◽  
Fish Diet ◽  
Sustainable Aquaculture ◽  
Herbal Supplements ◽  
Aquatic Animals ◽  
Gene Regulatory

The crucial need for safe and healthy aquatic animals obligates researchers in aquaculture to investigate alternative and beneficial additives. Medicinal herbals and their extracts are compromised with diverse effects on the performances of aquatic animals. These compounds can affect growth performance and stimulate the immune system when used in fish diet. In addition, the use of medicinal herbs and their extracts can reduce oxidative stress induced by several stressors during fish culture. Correspondingly, aquatic animals could gain increased resistance against infectious pathogens and environmental stressors. Nevertheless, the exact mode of action where these additives can affect aquatic animals’ performances is still not well documented. Understanding the mechanistic role of herbal supplements and their derivatives is a vital tool to develop further the strategies and application of these additives for feasible and sustainable aquaculture. Gene-related studies have clarified the detailed information on the herbal supplements’ mode of action when administered orally in aquafeed. Several review articles have presented the potential roles of medicinal herbs on the performances of aquatic animals. However, this review article discusses the outputs of studies conducted on aquatic animals fed dietary, medicinal herbs, focusing on the gene expression related to growth and immune performances. Furthermore, a particular focus is directed to the expected influence of herbal supplements on the reproduction of aquatic animals.

scholarly journals The Role of Hyaluronic Acid in Cartilage Boundary Lubrication

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1606 ◽  
Author(s):  
Weifeng Lin ◽  
Zhang Liu ◽  
Nir Kampf ◽  
Jacob Klein
Keyword(s):  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Surface Force ◽  
Force Balance ◽  
New Paradigm ◽  
Low Friction ◽  
Cartilage Surface ◽  
Boundary Lubricant ◽  
Lipid Layers

Hydration lubrication has emerged as a new paradigm for lubrication in aqueous and biological media, accounting especially for the extremely low friction (friction coefficients down to 0.001) of articular cartilage lubrication in joints. Among the ensemble of molecules acting in the joint, phosphatidylcholine (PC) lipids have been proposed as the key molecules forming, in a complex with other molecules including hyaluronic acid (HA), a robust layer on the outer surface of the cartilage. HA, ubiquitous in synovial joints, is not in itself a good boundary lubricant, but binds the PC lipids at the cartilage surface; these, in turn, massively reduce the friction via hydration lubrication at their exposed, highly hydrated phosphocholine headgroups. An important unresolved issue in this scenario is why the free HA molecules in the synovial fluid do not suppress the lubricity by adsorbing simultaneously to the opposing lipid layers, i.e., forming an adhesive, dissipative bridge between them, as they slide past each other during joint articulation. To address this question, we directly examined the friction between two hydrogenated soy PC (HSPC) lipid layers (in the form of liposomes) immersed in HA solution or two palmitoyl–oleoyl PC (POPC) lipid layers across HA–POPC solution using a surface force balance (SFB). The results show, clearly and surprisingly, that HA addition does not affect the outstanding lubrication provided by the PC lipid layers. A possible mechanism indicated by our data that may account for this is that multiple lipid layers form on each cartilage surface, so that the slip plane may move from the midplane between the opposing surfaces, which is bridged by the HA, to an HA-free interface within a multilayer, where hydration lubrication is freely active. Another possibility suggested by our model experiments is that lipids in synovial fluid may complex with HA, thereby inhibiting the HA molecules from adhering to the lipids on the cartilage surfaces.

scholarly journals Institutional-Political Scenarios for Anthropocene Society

2018 ◽  
Vol 60 (1) ◽  
pp. 57-94 ◽  
Author(s):  
Andrew J. Hoffman ◽  
P. Devereaux Jennings
Keyword(s):  
Social Science ◽  
Institutional Theory ◽  
Human Activity ◽  
Natural Environment ◽  
Environmental Sustainability ◽  
Social Sustainability ◽  
New Paradigm ◽  
Change Mechanisms ◽  
Main Change

Natural scientists have proposed that humankind has entered a new geologic epoch. Termed the “Anthropocene,” this new reality revolves around the central role of human activity in multiple Earth ecosystems. That challenge requires a rethinking of social science explanations of organization and environment relationships. In this article, we discuss the need to politicize institutional theory as a means understanding “Anthropocene Society,” and in turn what that resultant society means for the Anthropocene in the natural environment. We modify the constitutive elements of institutional orders and a set of main change mechanisms to explore three scenarios around which future Anthropocene Societies might be built—Collapsing Systems, Market Rules, and Cultural Re-Enlightenment. Simultaneously, we use observations from the Anthropocene to expose limitations in present institutional theory and propose extensions to remedy them. Overall, this article challenges organizational scholars to consider a new paradigm under which research in environmental sustainability and social sustainability takes place.

scholarly journals Designing good deception: Recursive theory of mind in lying and lie detection

2019 ◽  
Author(s):  
Lauren A. Oey ◽  
Adena Schachner ◽  
Edward Vul
Keyword(s):  
Theory Of Mind ◽  
Stochastic Game ◽  
Lie Detection ◽  
Ground Truth ◽  
New Paradigm ◽  
Human Ability ◽  
Formal Framework ◽  
Recursive Theory ◽  
Better Than

The human ability to deceive others and detect deception has long been tied to theory of mind. We make a stronger argument: in order to be adept liars – to balance gain (i.e. maximizing their own reward) and plausibility (i.e. maintaining a realistic lie) – humans calibrate their lies under the assumption that their partner is a rational, utility-maximizing agent. We develop an adversarial recursive Bayesian model that aims to formalize the behaviors of liars and lie detectors. We compare this model to (1) a model that does not perform theory of mind computations and (2) a model that has perfect knowledge of the opponent’s behavior. To test these models, we introduce a novel dyadic, stochastic game, allowing for quantitative measures of lies and lie detection. In a second experiment, we vary the ground truth probability. We find that our rational models qualitatively predict human lying and lie detecting behavior better than the non-rational model. Our findings suggest that humans control for the extremeness of their lies in a manner reflective of rational social inference. These findings provide a new paradigm and formal framework for nuanced quantitative analysis of the role of rationality and theory of mind in lying and lie detecting behavior.

scholarly journals AI-Enabled Sensing and Decision-Making for IoT Systems

Complexity ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Hao Qinxia ◽  
Shah Nazir ◽  
Ma Li ◽  
Habib Ullah ◽  
Wang Lianlian ◽  
...  
Keyword(s):  
Decision Making ◽  
Real Life ◽  
Research Community ◽  
Smart Sensors ◽  
Future Research ◽  
New Paradigm ◽  
Exclusion Criteria ◽  
Intelligent Devices ◽  
Research Questions

The influential stage of Internet of Things (IoT) has reformed all fields of life in general but specifically with the emergence of artificial intelligence (AI) has drawn the attention of researchers into a new paradigm of life standard. This revolution has been accepted around the globe for making life easier with the use of intelligent devices such as smart sensors, actuators, and many other devices. AI-enabled devices are more intelligent and capable of doing a specific task which saves a lot of resources and time. Different approaches are available in the existing literature to tackle diverse issues of real life based on AI and IoT systems. The role of decision-making has its own importance in the AI-enabled and IoT systems. In-depth knowledge of the existing literature is dire need of the research community to summarize the literature in effective way by which practitioners and researchers can benefit from the prevailing proofs and suggest new solutions for solving a particular problem of AI-enabled sensing and decision-making for the IoT system. To facilitate research community, the proposed study presents a systematic literature review of the existing literature, organizes the evidences in a systematic way, and then analyzes it for future research. The study reported the literature of the last 5 years based on the research questions, inclusion and exclusion criteria, and quality assessment of the selected study. Finally, derivations are drawn from the included paper for future research.

Rethinking the Role of Islam in Malaysian Politics: A Case Study of Parti Amanah Negara

ICR Journal ◽  
2017 ◽  
Vol 8 (4) ◽  
pp. 457-472
Author(s):  
Maszlee Malik
Keyword(s):  
Political Activism ◽  
Political Islam ◽  
General Assembly ◽  
New Paradigm ◽  
Islamic Political Thought ◽  
Party Members ◽  
Malaysian Politics ◽  
Different Levels

In 2015, a group of sidelined and outcast progressive leaders and other activists from Parti Islam SeMalaysia (the Islamic Party of Malaysia, also known as PAS) decided to leave that organisation and form Parti Amanah Negara (AMANAH). The establishment of this new party was linked to efforts at saving the moderate form of Islamic political thought once embraced by PAS; the founders of AMANAH claimed that the new PAS leadership, elected during the 2015 Muktamar (Annual General Assembly), were too conservative and threatened the continuation of this moderate heritage. According to its founders, AMANAH has therefore been established to bring Islamic political activism into a new paradigm, with the hope of shaping a future Islamic discourse in Malaysia that is more inclusive, moderate, democratic and progressive. This article is an attempt to understand the party’s ideology, supposedly a new discourse in political Islam, and evaluate the level of adherence it enjoys amongst AMANAH members. This is done through a qualitative study conducted with 100 party members from different levels.

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