scholarly journals Time course of osmoregulatory and metabolic changes during osmotic acclimation in Sparus auratus

2005 ◽  
Vol 208 (22) ◽  
pp. 4291-4304 ◽  
Author(s):  
S. Sangiao-Alvarellos
Keyword(s):  
Time Course ◽  
Metabolic Changes ◽  
Osmotic Acclimation ◽  
Sparus Auratus

scholarly journals Comparative Transcriptome Analysis Provides Novel Insight into Morphologic and Metabolic Changes in the Fat Body during Silkworm Metamorphosis

2018 ◽  
Vol 19 (11) ◽  
pp. 3525 ◽  
Author(s):  
Jian Peng ◽  
Zheng Li ◽  
Yan Yang ◽  
Peng Wang ◽  
Xuan Zhou ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Transcriptome Analysis ◽  
Time Course ◽  
Fat Body ◽  
Metabolic Changes ◽  
Bmp Signaling ◽  
Comparative Transcriptome ◽  
Lipid Mobilization ◽  
Comparative Transcriptome Analysis ◽  
Insight Into

The fat body plays key roles in energy storage and utilization as well as biosynthetic and metabolic activities in insects. During metamorphosis from larva to pupa, the fat body undergoes dramatic changes in morphology and metabolic processes. However, the genetic basis underlying these changes has not been completely understood. In this study, the authors performed a time-course transcriptome analysis of the fat body during silkworm metamorphosis using RNA-sequencing. A total of 5217 differentially expressed genes (DEGs) were identified in the fat body at different developmental time points. DEGs involved in lipid synthesis and degradation were highly expressed at the third day of the last larval instar and during the prepupal-pupal transition, respectively. DEGs involved in the ecdysone signaling and bone morphogenetic protein (BMP) signaling pathways that modulate organ development exhibited a high expression level during the fat body remodeling process from prepupa to pupa. Intriguingly, the RNA interference-mediated knockdown of either decapentaplegic (Dpp) or protein 60A (Gbb), two DEGs involved in the BMP signaling pathway, inhibited fat body dissociation but promoted lipid mobilization, suggesting that the BMP signaling pathway not only is required for fat body remodeling, but also moderately inhibits lipid mobilization to ensure an appropriate lipid supply during the pupal-adult transition. In conclusion, the comparative transcriptome analysis provides novel insight into morphologic and metabolic changes in the fat body during silkworm metamorphosis.

scholarly journals Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics

Metabolites ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 350 ◽  
Author(s):  
Jacquelyn M. Walejko ◽  
Anushka Chelliah ◽  
Maureen Keller-Wood ◽  
Clive Wasserfall ◽  
Mark Atkinson ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cord Blood ◽  
Time Course ◽  
Tca Cycle ◽  
Metabolic Changes ◽  
Increased Risk ◽  
Management And Development ◽  
Branched Chain ◽  
Tca Cycle Intermediates ◽  
Poor Outcomes

Women with diabetes during pregnancy are at increased risk of poor maternal and neonatal outcomes. Despite this, the effects of pre-gestational (PGDM) or gestational diabetes (GDM) on metabolism during pregnancy are not well understood. In this study, we utilized metabolomics to identify serum metabolic changes in women with and without diabetes during pregnancy and the cord blood at birth. We observed elevations in tricarboxylic acid (TCA) cycle intermediates, carbohydrates, ketones, and lipids, and a decrease in amino acids across gestation in all individuals. In early gestation, PGDM had elevations in branched-chain amino acids and sugars compared to controls, whereas GDM had increased lipids and decreased amino acids during pregnancy. In both GDM and PGDM, carbohydrate and amino acid pathways were altered, but in PGDM, hemoglobin A1c and isoleucine were significantly increased compared to GDM. Cord blood from GDM and PGDM newborns had similar increases in carbohydrates and choline metabolism compared to controls, and these alterations were not maternal in origin. Our results revealed that PGDM and GDM have distinct metabolic changes during pregnancy. A better understanding of diabetic metabolism during pregnancy can assist in improved management and development of therapeutics and help mitigate poor outcomes in both the mother and newborn.

Time Course of Muscle Metabolic Changes during Tourniquet Ischemia in Man

1981 ◽  
Vol 02 (01) ◽  
pp. 50-53 ◽  
Author(s):  
T. Häggmark ◽  
E. Jansson ◽  
E. Eriksson
Keyword(s):  
Time Course ◽  
Metabolic Changes ◽  
Tourniquet Ischemia

Relationship between GH-induced metabolic changes and changes in body composition: A dose and time course study in GH-deficient adults

2008 ◽  
Vol 18 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Morton G. Burt ◽  
James Gibney ◽  
David M. Hoffman ◽  
A. Margot Umpleby ◽  
Ken K.Y. Ho
Keyword(s):  
Body Composition ◽  
Time Course ◽  
Metabolic Changes ◽  
Time Course Study

scholarly journals Time Course of Early Metabolic Changes following Diffuse Traumatic Brain Injury in Rats as Detected by1H NMR Spectroscopy

2007 ◽  
Vol 24 (6) ◽  
pp. 944-959 ◽  
Author(s):  
José M. Pascual ◽  
Juan Solivera ◽  
Ruth Prieto ◽  
Laura Barrios ◽  
Pilar López-Larrubia ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Nmr Spectroscopy ◽  
Time Course ◽  
Metabolic Changes

scholarly journals Investigating the Metabolic Changes due to Visual Stimulation using Functional Proton Magnetic Resonance Spectroscopy at 7 T

2012 ◽  
Vol 32 (8) ◽  
pp. 1484-1495 ◽  
Author(s):  
Yan Lin ◽  
Mary C Stephenson ◽  
Lijing Xin ◽  
Antonio Napolitano ◽  
Peter G Morris
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Time Course ◽  
Visual Stimulation ◽  
Metabolic Changes ◽  
Resonance Spectroscopy ◽  
Functional Changes ◽  
Increased Activity

Proton magnetic resonance spectroscopy (1H-MRS) has been used to demonstrate metabolic changes in the visual cortex on visual stimulation. Small (2% to 11%) but significant stimulation induced increases in lactate, glutamate, and glutathione were observed along with decreases in aspartate, glutamine, and glycine, using 1H-MRS at 7 T during single and repeated visual stimulation. In addition, decreases in glucose and increases in γ-aminobutyric acid (GABA) were seen but did not reach significance. Changes in glutamate and aspartate are indicative of increased activity of the malate–aspartate shuttle, which taken together with the opposite changes in glucose and lactate, reflect the expected increase in brain energy metabolism. These results are in agreement with those of Mangia et al. In addition, increases in glutamate and GABA coupled with the decrease in glutamine can be interpreted in terms of increased activity of the neurotransmitter cycles. An entirely new observation is the increase of glutathione during prolonged visual stimuli. The similarity of its time course to that of glutamate suggests that it may be a response to the increased release of glutamate or to the increased production of reactive oxygen species. Together, these observations constitute the most detailed analysis to date of functional changes in human brain metabolites.

scholarly journals Dynamic Metabolic Changes during the First 3 Months after90Y-Ibritumomab Tiuxetan Radioimmunotherapy

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Miwako Takahashi ◽  
Toshimitsu Momose ◽  
Keitaro Koyama ◽  
Motoshi Ichikawa ◽  
Mineo Kurokawa ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Time Course ◽  
Tumor Response ◽  
Standard Uptake Value ◽  
Metabolic Changes ◽  
Ibritumomab Tiuxetan ◽  
Before And After ◽  
Pet Scans

Objective. To elucidate the time course of tumor metabolism during the first 3 months after90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma.Materials and Methods. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and after 1-, 4-, and 12-week RIT with90Y-ibritumomab tiuxetan. Tumor metabolic activity on FDG-PET scans was assessed as the maximum standard uptake value (SUVmax).Results. Decrease in metabolism was detected 1 week after RIT. In the most decreased lesion, SUVmax decreased to 20% of the baseline value during the first week. Most lesions continued to decrease for up to 4 weeks. Some lesions showed increased metabolism from 4 to 12 weeks, while the level of FDG accumulations at 12 weeks was still lower than the baseline.Conclusions. Tumor response to RIT could be observed as early as 1 week after the administration of RIT. After tumor activity decreases, the metabolism may increase at least between 4 and 12 weeks. It suggests that the metabolic changes should be carefully evaluated during this period.

Interaction of short-term testosterone treatment with osmotic acclimation in the gilthead sea bream Sparus auratus

2007 ◽  
Vol 153 (4) ◽  
pp. 661-671 ◽  
Author(s):  
Francisco J. Arjona ◽  
Susana Sangiao-Alvarellos ◽  
Sergio Polakof ◽  
Angel García-López ◽  
María P. Martín del Río ◽  
...  
Keyword(s):  
Gilthead Sea Bream ◽  
Sea Bream ◽  
Short Term ◽  
Testosterone Treatment ◽  
Osmotic Acclimation ◽  
Sparus Auratus
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