ALKALINE TIDE TURNS FOR DOGFISH

2005 ◽  
Vol 208 (14) ◽  
pp. i-i
Author(s):  
K. Arney
Keyword(s):  
1933 ◽  
Vol 101 (3) ◽  
pp. 781-785
Author(s):  
Roger S. Hubbard ◽  
Samuel A. Munford ◽  
James Tyner

1980 ◽  
Vol 239 (6) ◽  
pp. G536-G542
Author(s):  
R. Schiessel ◽  
A. Merhav ◽  
J. B. Matthews ◽  
L. A. Fleischer ◽  
A. Barzilai ◽  
...  

In in vitro bullfrog fundic mucosa inhibited with 10(-3) M metiamide and exposed to a luminal pH of 2 a progressive slow decline in potential difference (PD) and short-circuit current (Isc) and a rise in resistance (R) were observed when the nutrient solution (N) contained 18 mM HCO3(-), but these changes were restored by an N containing 50 mM HCO3(-). Substitution of PO4(3-) or N-tris(hydroxymethyl)-methyl-2-aminoethanesulfonic acid for NHO3(-) in N caused a rapid drop in PD and Isc in inhibited tissues, changes that could be prevented by 10(-4) M histamine. Ulceration occurred more frequently in metiamide-inhibited gastric sacs exposed to artificial gastric juice with an N of 18 mMHCO3(-) than with 50 mM HCO3(-), but histamine prevented ulceration in the 18 mM HCO3(-) solution. JnetCl approximated Isc under most experimental conditions in inhibited mucosa and was reduced dramatically as were both Jn leads to sCl and Js leads to nCl when HCO3(-) was removed from N. In histamine-stimulated tissues, removal of nutrient HCO3(-) did not influence Cl- transport. Our results are consistent with the proposal that HCO3(-) in N supports normal Cl- flux and that the alkaline tide of actively secreting oxyntic cells can do the same in the absence of ambient HCO3(-).


Digestion ◽  
1977 ◽  
Vol 15 (3) ◽  
pp. 175-181 ◽  
Author(s):  
W. Hughes ◽  
S. Cohen ◽  
D. Arvan ◽  
B. Seamonds

2008 ◽  
Vol 81 (3) ◽  
pp. 278-287 ◽  
Author(s):  
Chris M. Wood ◽  
Makiko Kajimura ◽  
Thomas P. Mommsen ◽  
Patrick J. Walsh

1950 ◽  
Vol 74 (4) ◽  
pp. 866-869 ◽  
Author(s):  
R. A. Coulson ◽  
T. Hernandez ◽  
H. C. Dessauer
Keyword(s):  

JAMA ◽  
1922 ◽  
Vol 79 (24) ◽  
pp. 2021 ◽  
Author(s):  
A. L. Benedict
Keyword(s):  

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